Association of SLC11A1 (NRAMP1) polymorphisms with pulmonary Mycobacterium avium complex infection

Polymorphism, Expression of Natural Resistance-associated Macrophage Protein 1 Encoding Gene (<i>NRAMP1</i>) and Its Association with Immune Traits in Pigs

“…Moreover, NRAMP1 gene has an important role in activation of a large subset of innate lymphocytes that are critical sources of interferon -γ (Hedges et al, 2013). In humans, mutations in NRAMP1 gene are associated with T1D (Yang et al, 2011), tuberculosis risk (Meilang et al, 2012) and pulmonary Mycobacterium avium complex infection (Sapkota et al, 2012). In pigs, a single nucleotide polymorphism in the sixth intron of the NRAMP1 gene has been found to be significantly associated with polymorphonuclear leukocyte levels, cytotoxin on monocytes and 180-day-old body weight (Wu et al, 2008).…”

British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD)

“…A number of immunodeficiencies have been associated with NTM infection,79 80 including inherited disorders of IFNγ-IL12 pathway (eg, IFNγR1 mutations),81 other cytokine signalling (eg, STAT mutations),82 and macrophage and dendritic cell function (eg, GATA2,83 NRAMP184), as well as acquired immunodeficiencies including HIV-AIDS85 and functional anti-interferon gamma antibodies 86. Although frequently presenting with disseminated NTM infection, immunodeficiencies should also be considered in individuals with recurrent, persistent or severe pulmonary infection, particularly with NTM species that are normally non-pathogenic, as well as in those presenting with NTM disease in the absence of structural lung disease, or in those presenting at a young age.…”

Distinct Clinical Features in Nontuberculous Mycobacterial Disease with or without Latent Tuberculosis Infection

“…Our finding may imply that NTM co-infection with LTBI can synergistically induce large amounts of OPN. The synergistic effect could be explained by the natural resistance associated macrophage protein 1 (NRAMP1) because it was reported as host genetic factor for development of both tuberculosis and NTM, however the involvement of NRAMP1 in OPN production was not studied (Li et al 2011;Sapkota et al 2012).…”