Natural Radioactivity in Southwest France and Its Possible Genetic Consequences for Mammals

Léonard, A.; Delpoux, M.; Decat, G.; Léonard, Évelyne

doi:10.2307/3575086

Cited by 16 publications

(9 citation statements)

References 11 publications

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“…This relatively short lifespan could probably also explain the lack of a dose-response relationship in rabbits exposed to chronic irradiation over several months ) and, if true for other species, might also be responsible for the observation that no aberrations were found in animals exposed to chemical mutagens (Leonard et al . 1974, Leonard et al . 1977 .…”

Section: Discussionmentioning

confidence: 96%

“…Furthermore, cytological observations on lymphocytes from animals intoxicated by different chemicals such as fluoride (Leonard, Gerber, Decat and Leonard 1977) or heavy metals (Leonard, Deknudt and Debackere 1974) which have been shown to induce chromosome aberrations in other systems, yielded negative results .…”

Section: Introductionmentioning

confidence: 96%

“…(Bender and Gooch 1962, Evans 1971, Dolphin and Purrott 1971, Purrott and Lloyd 1972, Lloyd, Purrott, Dolphin, Bolton, Edwards and Corp 1975 . The hazards to man from occupational or accidental exposure to chemical mutagens may also be assessed qualitatively in this way, providing relevant control populations can be found (Evans 1976) .…”

Section: Introductionmentioning

confidence: 97%

“…During chronic exposure of man to radiation, damage seems to be accumulated over a long period of time (Evans, Buckton, Hamilton and Carothers 1979) whereas no clear-cut dose-effect relationship was obtained for rabbits exposed to low-dose chronic gamma irradiation (Leonard, Delpoux, Decat and Leonard 1979) . Furthermore, cytological observations on lymphocytes from animals intoxicated by different chemicals such as fluoride (Leonard, Gerber, Decat and Leonard 1977) or heavy metals (Leonard, Deknudt and Debackere 1974) which have been shown to induce chromosome aberrations in other systems, yielded negative results .…”

Section: Introductionmentioning

confidence: 99%

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Lymphocyte Lifetime in the Rabbit Measured by the Decline in Radiation-induced Chromosome Damage

Decat¹,

Léonard²

1980

International Journal of Radiation Biology and Related Studies

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The life span of rabbit lymphocytes carrying radiation-induced chromosome aberrations has been studied by following the decline in aberration frequency as a function of the time after irradiation. Female rabbits were given a whole body X-ray dose of 300 rad. The day before exposure and at 2 hours, 14, 28, 42, 56, 84, 140, 250 and 500 days thereafter, blood samples were taken from a marginal ear vein of each animal. A plot of log abnormalities against time suggests an exponential decline for dicentrics and fragments up to 140 days, the half time for dicentrics and fragments being 70 and 46 days respectively. The results of the present investigation thus demonstrate that because of their shorter life span, in vivo observations on aberrations in rabbit lymphocytes are not suitable for extrapolation of information on chronic exposure to man.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 97%