Natural products to drugs: natural product-derived compounds in clinical trials

Butler, Mark S.

doi:10.1039/b514294f

Cited by 814 publications

(505 citation statements)

References 570 publications

(338 reference statements)

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“…In 2002, the sales on terpene-based pharmaceuticals were approximately US $12 billion [5]. Examples are the antimalarial drug Artemisinin and the anticancer drug Taxol®, two of the better known terpene-based drugs [6][7][8]. Menthol and camphor are non-prescription drugs also widely used in the pharmaceutical field.…”

Section: Introductionmentioning

confidence: 99%

Terpenes solubility in water and their environmental distribution

Martins

Silva

Ferreira

et al. 2017

Journal of Molecular Liquids

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Terpenes and terpenoids belong to the largest and most diverse class of natural products. Due to the increasing importance of their applications and the emerging perception of their impact on the environment, the available physico-chemical characterization is insufficient. In this work the water solubility of geraniol, linalool, DL-citronellol, thymol, eugenol, carvacrol and p-cymene, in the temperature range from (298.15 to 323.15) K, and at atmospheric pressure, is studied. Due to the low solubility of these compounds a novel technique was adopted for their measurements and validated using the aqueous solubility data for sparingly soluble aromatic compounds. The thermodynamic properties of solution were derived from the experimental data at infinite dilution. It is shown that the solubility of terpenes in water is an endothermic process confirming the existence of UCST phase diagrams, and only for carvacrol and eugenol is entropically driven. The experimental information is shown in a two-dimensional chemical space diagram providing indications to their probable distribution in the environment once released.

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Section: Introductionmentioning

confidence: 99%

Terpenes solubility in water and their environmental distribution

Martins

Silva

Ferreira

et al. 2017

Journal of Molecular Liquids

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“…Natural products have been -and continue to be -a rich source of drugs 136,137 . To base the search for treatments of a given medical condition on natural products has a variety of advantages: Natural products exhibit a large structural diversity and complexity that remains unmatched by other drug formats 138,139 .…”

Section: Why Natural Products?mentioning

confidence: 99%

Antiviral drug discovery: broad-spectrum drugs from nature

et al. 2015

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, but cannot be converted to PDF. You must view these files (e.g. movies) online.Scheme 1_(structures 1-5)_named.cdx Scheme 2_(structures 6-8)_named.cdx Scheme 3_(structure 9)_named.cdx Scheme 4_(structure 10)_named.cdx Scheme 5_ (structures 11-12) The development of drugs with broad-spectrum antiviral activities is a long pursued goal in drug discovery. It has been shown that blocking co-opted host-factors abrogates the replication of many viruses, yet the development of such host-targeting drugs has been met with skepticism mainly due to toxicity issues and poor translation to in vivo models. With the advent of new and more powerful screening assays and prediction tools, the idea of a drug that can efficiently treat a wide range of viral infections by blocking specific host functions has rebloomed. Here we critically review the state-of-the-art in broad-spectrum antiviral drug discovery. We discuss putative targets and treatment strategies, taking particular focus on natural products as promising starting points for antiviral lead development.

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“…New structurally diverse natural compounds isolated from plant sources [5][6] have been considered as prototypes, leads or heads of series and their later structural modification has generated compounds with pharmacological activities and real therapeutic potential [7][8][9][10][11][12]. The continued search for new NPs extracted from living organisms is strongly driven by the continued evolution of infective agents and the expanding scope of medical and therapeutic targets [14][15][16][17].…”

Section: Morphinementioning

confidence: 99%

Natural products as lead compounds in drug discovery

Khazir

Mir

et al. 2013

Journal of Asian Natural Products Research

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Abstract:This review surveys the diversity of natural products derived from terrestrial plants, microorganisms, marine organisms and fungi and utilised in the treatment of various diseases.A wide spectrum of compounds derived from these sources has found many applications in the fields of medicine, pharmacy and general biology. The enormous structural diversity of natural products and their medicinal significance has led researchers to predict that screening natural resources will generate new -lead‖ compounds. It is well established that structural analogues with greater pharmacological activity and fewer side effects can be generated by molecular modification of the functional groups of such lead compounds.

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Natural products to drugs: natural product-derived compounds in clinical trials

Cited by 814 publications

References 570 publications

Terpenes solubility in water and their environmental distribution

Terpenes solubility in water and their environmental distribution

Antiviral drug discovery: broad-spectrum drugs from nature

Natural products as lead compounds in drug discovery

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