Natural Products Published in 2009 from Plants Traditionally Used to Treat Malaria

Béro, Joanne; Quetin-Leclercq, Joëlle

doi:10.1055/s-0030-1250405

Cited by 40 publications

(23 citation statements)

References 53 publications

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“…The IC 50 values for these compounds were in the μ M range as it has been reported for other STLs [12] and particularly for pseudoguaianolides such as helenalin and its ester derivatives [13]. …”

Section: Resultssupporting

confidence: 59%

In Vitro Antiplasmodial Activity of Sesquiterpene Lactones from Ambrosia tenuifolia

Sülsen

Yappu

Laurella

et al. 2011

Evidence-Based Complementary and Alternative Medicine

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The in vitro antiplasmodial activity of Ambrosia tenuifolia organic extract and its isolated sesquiterpene lactones, psilostachyin and peruvin, has been evaluated against Plasmodium falciparum F32 and W2 strains. The cytotoxicity of both compounds was determined on lymphoid cells, and their corresponding selectivity indexes (SIs) were calculated. Peruvin was the most active compound on F32 strain of P. falciparum with a 50% inhibitory concentration value (IC50) of 0.3 μg/mL (1.1 μM) whereas psilostachyin showed activity on both strains (IC50 = 0.6 (2.1 μM) and 1.8 μg/mL (6.4 μM)). Fifty percent cytotoxic concentration (CC50) values (48 h) were 6.8 μg/mL (24.3 μM) and 10.0 μg/mL (37.9 μM) for psilostachyin and peruvin, respectively.

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Section: Resultssupporting

confidence: 59%

In Vitro Antiplasmodial Activity of Sesquiterpene Lactones from Ambrosia tenuifolia

Sülsen

Yappu

Laurella

et al. 2011

Evidence-Based Complementary and Alternative Medicine

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“…However, the last review on anti-malarial compounds from African flora dates back about ten years [13], with other reviews focusing on plant-screening campaigns in particular regions and/or countries in Africa [15-35] or on active compounds obtained by bioassay-guided fractionation efforts from given countries and/or regions, not covering an entire continent [36-41]. Even though natural products that are active against P. falciparum have been discussed in a number of review papers [1,42-48], the goal has been to provide an coverage of the most promising anti-malarials from the entire African continent, by giving an overview of the most pertinent in vitro and in vivo screening results reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

The potential of anti-malarial compounds derived from African medicinal plants, part II: a pharmacological evaluation of non-alkaloids and non-terpenoids

Ntie‐Kang

Onguéné

Lifongo

et al. 2014

Malar J

114

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Malaria is currently a public health concern in many countries in the world due to various factors which are not yet under check. Drug discovery projects targeting malaria often resort to natural sources in the search for lead compounds. A survey of the literature has led to a summary of the major findings regarding plant-derived compounds from African flora, which have shown anti-malarial/antiplasmodial activities, tested by in vitro and in vivo assays. Considerations have been given to compounds with activities ranging from “very active” to “weakly active”, leading to >500 chemical structures, mainly alkaloids, terpenoids, flavonoids, coumarins, phenolics, polyacetylenes, xanthones, quinones, steroids and lignans. However, only the compounds that showed anti-malarial activity, from “very active” to “moderately active”, are discussed in this review.

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“…Nkunya et al (1991) described a study of nine species of Uvaria in which the following antimalarial substances were isolated: uvaretin, diuvaretin and (8',9'-dihydroxy)-3-farnesylindole (IC 50 = 3.5, 4.2 and 2.7 μg/mL, respectively, against the K1 strain of P. falciparum. In their review on natural products from traditionally used antimalarial plants, Bero and Quetin-Leclercq (2011) reported that the antiplasmodial substance (+)-3-acetylaltholactone was isolated from the extracts of the flowers of Goniothalamus laoticus Bân and exhibited in vitro activity against the K1 strain of P. falciparum (IC 50 = 9.5 μM). In vivo activity was observed for another Annonaceous species, Annickia chlorantha (cited as Enantia chlorantha), which is found in Nigeria and other parts of West Africa.…”

Section: Xylopiamentioning

confidence: 99%

Plants of the Annonaceae traditionally used as antimalarials: a review

et al. 2014

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ABSTRACT-Species of the Annonaceae family are used all over the tropics in traditional medicine in tropical regions for the treatment of malaria and other illnesses. Phytochemical studies of this family have revealed chemical components which could offer new alternatives for the treatment and control of malaria. Searches in scientific reference sites (SciFinder Scholar, Scielo, PubMed, ScienceDirect and ISI Web of Science) and a bibliographic literature search for species of Annonaceae used traditionally to treat malaria and fever were carried out. This family contains 2,100 species in 123 genera. We encountered 113 articles reporting medicinal use of one or more species of this family including 63 species in 27 genera with uses as antimalarials and febrifuges. Even though the same species of Annonaceae are used by diverse ethnic groups, different plant parts are often chosen for applications, and diverse methods of preparation and treatment are used. The ethanol extracts of Polyalthia debilis and Xylopia aromatica proved to be quite active against Plasmodium falciparum in vitro (median inhibition concentration, IC 50 < 1.5 µg/mL). Intraperitoneal injection of Annickia chlorantha aqueous extracts (cited as Enantia chlorantha) cleared chloroquine-resistant Plasmodium yoelii nigeriensis from the blood of mice in a dose-dependant manner. More phytochemical profiles of Annonaceous species are required; especially information on the more commonly distributed antimalarial compounds in this family.

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Natural Products Published in 2009 from Plants Traditionally Used to Treat Malaria

Cited by 40 publications

References 53 publications

In Vitro Antiplasmodial Activity of Sesquiterpene Lactones from Ambrosia tenuifolia

In Vitro Antiplasmodial Activity of Sesquiterpene Lactones from Ambrosia tenuifolia

The potential of anti-malarial compounds derived from African medicinal plants, part II: a pharmacological evaluation of non-alkaloids and non-terpenoids

Plants of the Annonaceae traditionally used as antimalarials: a review

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