Natural Products for Cancer Prevention and Interception: Preclinical and Clinical Studies and Funding Opportunities

Abstract

Multiple agents derived from natural products (NPs) have been evaluated for cancer prevention and interception, either alone or in combination. The National Cancer Institute (NCI) is very interested in advancing research to identify additional agents that, alone or in combination, may prove useful in cancer prevention. Below, we provide an overview of NP studies in cancer prevention and interception, both individual agents and combination interventions. Given that findings from many preclinical studies evaluating individual agents have generally not been confirmed in human studies, our focus with individual NPs in this review is on studies involving humans, especially clinical trials. Fewer combination intervention studies have been conducted, so we have broadened our review to include preclinical studies. We conclude with how the Division of Cancer Prevention (DCP) within the NCI is providing funding to encourage the research community to propose natural product studies in cancer prevention and interception to advance the field.

Histone Acyl Code in Precision Oncology: Mechanistic Insights from Dietary and Metabolic Factors

“…The anticancer role of dietary bioactive compounds and phytochemicals mediated by histone PTMs has been previously reviewed [197][198][199][200][201]. Several clinical trials involving natural products and diet interventions for cancer therapy have also been extensively reviewed [202][203][204][205][206]. This section explores how dietary and metabolism-derived histone acylation events can be used as an attractive target for cancer prevention and therapy.…”