Histone Acyl Code in Precision Oncology: Mechanistic Insights from Dietary and Metabolic Factors
Sultan Neja,
Wan Mohaiza Dashwood,
Roderick H. Dashwood
et al.
Abstract:Cancer etiology involves complex interactions between genetic and non-genetic factors, with epigenetic mechanisms serving as key regulators at multiple stages of pathogenesis. Poor dietary habits contribute to cancer predisposition by impacting DNA methylation patterns, non-coding RNA expression, and histone epigenetic landscapes. Histone post-translational modifications (PTMs), including acyl marks, act as a molecular code and play a crucial role in translating changes in cellular metabolism into enduring pat… Show more
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