Natural Products as Sources of Multitarget Compounds: Advances in the
Development of Ferulic Acid as Multitarget Therapeutic

Kaur, Rajwinder; Sood, Ankita; Lang, Damanpreet Kaur; Arora, Raksha; Kumar, Neeraj; Diwan, Vishal; Saini, Balraj

doi:10.2174/1568026622666220117105740

Cited by 26 publications

(15 citation statements)

References 104 publications

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“…The use of ferulic acid ointment during healing can inhibit lipid peroxidation and increase catalase, superoxide dismutase, and glutathione (Ghaisas et al, 2014). Considering the safety of drugs, ferulic acid, as an important potential therapeutic agent, has the characteristics of low cost, easy availability, low toxicity, and few side effects (Kaur et al, 2022).…”

Section: Ferulic Acidmentioning

confidence: 99%

The potential application of natural products in cutaneous wound healing: A review of preclinical evidence

et al. 2022

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Under normal circumstances, wound healing can be summarized as three processes. These include inflammation, proliferation, and remodeling. The vast majority of wounds heal rapidly; however, a large percentage of nonhealing wounds have still not been studied significantly. The factors affecting wound nonhealing are complex and diverse, and identifying an effective solution from nature becomes a key goal of research. This study aimed to highlight and review the mechanisms and targets of natural products (NPs) for treating nonhealing wounds. The results of relevant studies have shown that the effects of NPs are associated with PI3K-AKT, P38MAPK, fibroblast growth factor, MAPK, and ERK signaling pathways and involve tumor growth factor (TNF), vascular endothelial growth factor, TNF-α, interleukin-1β, and expression of other cytokines and proteins. The 25 NPs that contribute to wound healing were systematically summarized by an inductive collation of the six major classes of compounds, including saponins, polyphenols, flavonoids, anthraquinones, polysaccharides, and others, which will further direct the attention to the active components of NPs and provide research ideas for further development of new products for wound healing.

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Section: Ferulic Acidmentioning

confidence: 99%

The potential application of natural products in cutaneous wound healing: A review of preclinical evidence

et al. 2022

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“…In recent years, FA has received increasing attention in the field of pharmaceutical, food, and cosmetics industry. It has low toxicity and possesses multiple pharmacological properties, including anti-oxidation, antiinflammation, anti-thrombosis, and anti-carcinogenesis (11). Sustained FA supplement has been showed to inhibit microglia-mediated neuroinflammation in animal models of Alzheimer's and Parkinson's diseases (12), presenting a great prospect for the treatment of neurodegenerative disorders.…”

Section: Introductionmentioning

confidence: 99%

Ferulic acid alleviates retinal neovascularization by modulating microglia/macrophage polarization through the ROS/NF-κB axis

Sun

et al. 2022

Front. Immunol.

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Inflammation plays a pivotal role in ischemia-induced retinal neovascularization. Targeting microglia/macrophage-based neuroinflammation presents a promising therapeutic strategy. Ferulic acid (FA), a natural and active ingredient in plants, exerts favorable anti-oxidative and anti-inflammatory activities. In this study, we investigated the inhibitory effect of FA against hypoxia-induced retinal angiogenesis using cultured retinal vascular endothelial cells and an oxygen-induced retinopathy mouse (OIR) model. The immunoregulatory effect of FA on microglia/macrophage polarization was evaluated by detecting the expression of specific markers for both pro-inflammatory “M1” and anti-inflammatory “M2” phenotypes using co-immunostaining and polymerase chain reaction assays. The underlying molecular mechanism upon FA treatment was also explored. The results showed that FA supplement markedly inhibited retinal pathological angiogenesis both in vivo and in vitro. In addition, FA switched microglia/macrophage polarization from “M1” towards “M2” phenotype and alleviated the inflammatory response. Mechanically, the anti-angiogenic and anti-inflammatory properties of FA were mainly due to blockade of the ROS/NF-κB pathway. Our data demonstrated an anti-angiogenic effect of FA through regulating M1-to-M2 microglia/macrophage polarization, suggesting a potential therapeutic strategy for retinal neovascular diseases.

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“…Under the traditional concept of “one disease, one gene, one drug,” no specific treatment has been found. Therefore, multitargeted natural products involving a broad range of pharmacological activities are most likely to show potential superiority [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Resveratrol Ameliorates Lipopolysaccharide-Induced Sudden Sensorineural Hearing Loss in In Vitro Model through Multitarget Antiapoptotic Mechanism Based on Network Pharmacology and Molecular Docking

Liu

Dong

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To explore the effects of resveratrol (RSV) on hair cell apoptosis caused by sudden sensorineural hearing loss (SSNHL) and its effect on lipopolysaccharide-induced apoptosis of HEI-OC1 cells. Methods. We used the network pharmacology method to screen molecules related to RSV for the treatment of SSNHL and analyzed these molecules and their enriched biological processes and signaling pathways through Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) analysis. We selected hub genes related to apoptosis using protein-protein interaction (PPI) analysis for in vitro and molecular docking verification. Results. Eighty overlapping genes were identified as potential targets for RSV treatment of SSNHL. Further GO analysis showed that the biological processes were mainly related to toxicity, cell proliferation, and lipopolysaccharide reactions. KEGG analysis showed that the AGE-RAGE signaling pathway in diabetic complications, Kaposi’s sarcoma-associated herpesvirus infection, FoxO signaling pathway, PI3K-Akt signaling pathway, and other inflammatory signaling pathways were concentrated. AKT1, STAT3, JUN, TNF, TP53, MAPK3, CASP3, and VEGFA were screened as HUB genes using PPI analysis. The apoptosis-related proteins TNF, CASP3, AKT1, and TP53 were selected for in vitro experiments, which showed that mRNA was significantly different before and after RSV intervention, confirming that the corresponding protein receptors could bind well with RSV. Conclusion. RSV mainly affects the prognosis of SSNHL through anti-inflammatory effects and may improve hair cell apoptosis caused by inflammatory factors through multitargeted interventions involving TNF, CASP3, AKT1, and TP53.

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Natural Products as Sources of Multitarget Compounds: Advances in the Development of Ferulic Acid as Multitarget Therapeutic

Cited by 26 publications

References 104 publications

The potential application of natural products in cutaneous wound healing: A review of preclinical evidence

The potential application of natural products in cutaneous wound healing: A review of preclinical evidence

Ferulic acid alleviates retinal neovascularization by modulating microglia/macrophage polarization through the ROS/NF-κB axis

Resveratrol Ameliorates Lipopolysaccharide-Induced Sudden Sensorineural Hearing Loss in In Vitro Model through Multitarget Antiapoptotic Mechanism Based on Network Pharmacology and Molecular Docking

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