Natural Products as Potential Sources of Antidiabetic Drugs

Osadebe, PO; Odoh, Estella U.; Uzor, Philip F.

doi:10.9734/bjpr/2014/8382

Cited by 65 publications

(49 citation statements)

References 53 publications

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“…Many antidiabetic drugs used in modern medicine have a natural origin [104], and administering them in their natural form may not be of much benefit. Metformin, a popular antidiabetic drug, is derived from a traditional antidiabetic plant, Galega officinalis (Goat’s Rue or French Lilac) [105], whose active ingredient was found to be galegine or isoamylene guanidine.…”

Section: Recommendations For Prospective Cam Usementioning

confidence: 99%

Unproven Therapies for Diabetes and Their Implications

et al. 2016

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Diabetes is a chronic disease and is one of the leading causes of morbidity and mortality worldwide. Being an ancient disease, many individuals follow complementary and alternative medicinal (CAM) therapies for either the cure or prevention of the disease. The popularity of these practices among the general public is in no way a testimony to their safety and efficacy. Due to the possibility of undesirable interactions with conventional medicines, it is imperative that patients are asked about CAM use during patient assessment. Patient- and physician-targeted awareness programs on various aspects of CAM use must be initiated to create a better understanding of evidence-based use of these practices. In addition, there should be guidelines in place based on clinical trial outcomes, and stricter regulations need to be enforced on CAM practices to ensure their safety and effectiveness.

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Section: Recommendations For Prospective Cam Usementioning

confidence: 99%

Unproven Therapies for Diabetes and Their Implications

et al. 2016

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“…Various plants being used traditionally have their extracts been proven scientifically to have the antidiabetic activity [4,5]. Solanum terminalefruits are used traditionally for diabetes management and on the previous study it has demonstrated hypoglycaemic efficacy by lowering the blood glucose levels in OGTT tested mice at 100 mg/kg body weight [6].…”

Section: Introductionmentioning

confidence: 99%

In-Vivo Antidiabetic Activity and Safety Profile of Fruits Extract and Fraction of Solanum Terminale Forsk (Solanaceae)

2020

International Journal of Medicinal Plants and Natural Products

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Background: Majority of people opt the use of traditional means of treatment especially medicinal plants on the notion of being safe since they are naturally derived. Objective: The study aimed at evaluation of the antidiabetic efficacy of extract and fraction and safety profile of Solanum terminale fruits extract in mice. Methods: Mice were induced diabetes by intraperitoneal injection of freshly prepared alloxan monohydrate 170 mg/kg BW.The diabetic mice were treated once daily with crude extract and methanol fraction (100 mg/kg BW) for 20 days, and FBG were recorded on day 1, 5, 10, 15 and 20. The effects of the extract and fraction on FBG levels of the diabetic mice were evaluated. OECD guidelines were used in assessing the acute oral toxicity of S. terminale fruits extract by single dose of crude extract at 2000 mg/kg BW. Mice were observed for 14 days for their mortality, behavioral and other changes. Before sacrifice, weight of mice and the visceral organs were recorded, and sent for histological evaluations. Results were expressed as mean ± SD, analysed by independent student's t-test, p <0.05 was considered as significant level. Ethical clearance was sought from MUHAS, IRB and animal care followed the EEC Directive of 1986; 86/609/EEC. Results: Crude ethanolic fruit extract of S. terminale and methanolic fraction demonstrated clinical and statistical significant blood glucose lowering efficacy in mice (p<0.05). Neither death nor abnormal changes in behavioral features in tested mice observed at 2000 mg/kg BW of S. terminale crude ethanolic fruit extract. The histological analysis demonstrated some organ derangements at 2000 mg/kg BW of S. terminale crude ethanolic fruit extract. Conclusion: The fruits are nearly safe for use in low doses/consumption. Further work is needed including more antidiabetic screening exhausting other techniques, further toxicological studies, identification of the active compounds, and standardization/formulation of S. terminale fruits products.

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“…In Africa, even in Gabon, plant based traditional medicine is widespread. These plants are used to treat all type of common pains and diseases, including those that modern medicines deal with such as cancer, renal insufficiency (Yokozawa et al, 2002), HIV (Helfer et al, 2014) and diabetes (Osabede et al, 2014). Several diabetes medicines used today have been developed or derived from plants that were once used in traditional medicine such as metformin, a biguanide derived from Galega officinalis L. (Fabaceae) (Osabede et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…These plants are used to treat all type of common pains and diseases, including those that modern medicines deal with such as cancer, renal insufficiency (Yokozawa et al, 2002), HIV (Helfer et al, 2014) and diabetes (Osabede et al, 2014). Several diabetes medicines used today have been developed or derived from plants that were once used in traditional medicine such as metformin, a biguanide derived from Galega officinalis L. (Fabaceae) (Osabede et al, 2014). Inversely, certain natural compounds from medicinal plants such as Tabernanthe iboga act like sulfonylureas, organic compounds that enhance insulin release from pancreatic beta cells (Souza et al, 2011).…”

Section: Introductionmentioning

confidence: 99%