Natural Products as Adjunctive Treatment for Pancreatic Cancer: Recent Trends and Advancements

Yue, Qing-Xi; Gao, Guogang; Zou, Gangyong; Yu, Huan; Zheng, Xi

doi:10.1155/2017/8412508

Cited by 71 publications

(53 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Prostate cancer patients still face the challenging problem of chemotherapy resistance (Erdogan, Turkekul, Serttas, & Erdogan, 2017). Many compounds derived from natural sources have shown therapeutic potential for malignant neoplasm treatment (Yue, Gao, Zou, Yu, & Xi, 2017). SDAPR, a well known protein of Cervus nippon Temm., has widespread applications as antioxidant, anti-inflammatory, and anticancer agent (Chen, Wang, Wu, Wang, & Li, 2009;Zhao, Wang, Zhang, & Xie, 2016).…”

Section: Discussionmentioning

confidence: 99%

Anticancer activity in vitro and biological safety evaluation in vivo of Sika deer antler protein

Yang

Wang²,

Sun

et al. 2017

J Food Biochem

View full text Add to dashboard Cite

This study evaluated the antitumor activity in vitro and biological safety in vivo of Sika deer antler protein (SDAPR). MTT and plate cloning assays were used for anti‐proliferation assessment of prostate cancer cells (PC‐3M) while flow cytometry and western blot were used for apoptosis analysis. In addition, biological safety of SDAPR was evaluated by acute oral toxicity test, bone marrow micronucleus assay and sperm aberration experiment. The results showed that SDAPR could suppress proliferation capacity and induce apoptosis on PC‐3M cells. No adverse effects were observed in Kunming mice following acute oral gavage with SDAPR at a dose of 8 g/kg body weight. The negative results obtained in bone marrow micronucleus test and sperm malformation assay demonstrated that SDAPR had no obvious toxicity to cause mutagenicity. In conclusion, SDAPR exerts anti‐tumor effect with high biological safety, which suggested that it could be used as a potential chemotherapeutic agent for human health. Practical applications It demonstrates that Sika deer antler protein has anticancer effects and high biological safety on prostate cancer cells. In addition, this paper provides scientific basis for treating tumors with Sika deer antler.

show abstract

Section: Discussionmentioning

confidence: 99%

Anticancer activity in vitro and biological safety evaluation in vivo of Sika deer antler protein

Yang

Wang²,

Sun

et al. 2017

J Food Biochem

View full text Add to dashboard Cite

show abstract

“…A review in Cochrane evaluated 15 Chinese studies, determining that the use of licorice root, ginseng, peony, and bark of Chinese cinnamon in AP reduced mortality, surgical interventions, and organ failure, although the quality of these studies was quite low [87,88].…”

Section: Alternative Medicinementioning

confidence: 99%

Review of Current Evidence in Acute Pancreatitis

Varley¹,

Rossi²,

Murray³

et al. 2019

obm hg

View full text Add to dashboard Cite

Acute pancreatitis (AP), an inflammatory condition of the pancreas, is one of the most common ailments of the gastrointestinal system, which results in significant morbidity and mortality. The main etiological causes of AP include alcohol consumption, gallstones, hypertriglyceridemia, and biliary stones. The clinical signs and symptoms of AP and the diagnostic criteria for this disease have been well established. Multiple scoring systems are applied to predict the severity and prognosis of AP, and the associated mortality. The present review of the literature highlights the recent significant contributions in the areas of etiology, risk factors, epidemiology, diagnosis, complications, prognosis, and the latest modalities in the treatment, which could be beneficial in the management of AP.

show abstract

“…Therapeutic role of multiple natural compounds is currently under investigation in vitro, in vivo and in the context of clinical trials. [177, 178]. There are several natural compounds under investigation for their potential role against PDAC pre-clinically and in Phase I/II clinical studies.…”

Section: Opportunities For Personalized Therapy For the Near Futurementioning

confidence: 99%

The evolution into personalized therapies in pancreatic ductal adenocarcinoma: challenges and opportunities

Tesfaye

Kamgar

Azmi

et al. 2017

Expert Review of Anticancer Therapy

View full text Add to dashboard Cite

Introduction: Pancreatic ductal adenocarcinoma (PDAC) is projected to be the second leading cause of cancer related mortality in the United States in 2030, with a 5-year overall survival of less than 10% despite decades of extensive research. Pancreatic cancer is marked by the accumulation of complex molecular changes, complex tumor-stroma interaction, and an immunosuppressive tumor microenvironment. PDAC has proven to be resistant to many cytotoxic, targeted and immunologic treatment approaches. Areas covered: In this paper, we review the major areas of research in PDAC, with highlights on the challenges and areas of opportunity for personalized treatment approaches. Expert commentary: The focus of research in pancreatic cancer has moved away from developing conventional cytotoxic combinations. The marked advances in understanding the molecular biology of this disease especially in the areas of the microenvironment, metabolism, and DNA repair have opened new opportunities for developing novel treatment strategies. Improved understanding of molecular abnormalities allows the development of personalized treatment approaches.

show abstract

Natural Products as Adjunctive Treatment for Pancreatic Cancer: Recent Trends and Advancements

Cited by 71 publications

References 66 publications

Anticancer activity in vitro and biological safety evaluation in vivo of Sika deer antler protein

Anticancer activity in vitro and biological safety evaluation in vivo of Sika deer antler protein

Review of Current Evidence in Acute Pancreatitis

The evolution into personalized therapies in pancreatic ductal adenocarcinoma: challenges and opportunities

Contact Info

Product

Resources

About