Natural products are an important source for proteasome regulating agents

An, Peng; Zhang, Lijun; Peng, Wei; Chen, Yuying; Liu, Qiuping; Luan, Xin; Zhang, Hong

doi:10.1016/j.phymed.2021.153799

Cited by 6 publications

(5 citation statements)

References 145 publications

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“…In addition to the frequently used chemical epigenetic modifiers mentioned in the review, many natural products have been screened to show chemical epigenetic regulating activities. They are an important source for chemical epigenetic modifiers applied in fungal secondary metabolisms [ 20 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…Chemical epigenetic modifiers are natural or synthetic small molecular compounds that target epigenetic enzymes, leading to epigenetic alterations of the organisms [ 17 , 20 , 21 ]. The structures of commonly used chemical epigenetic modifiers for generating specialized metabolism in fungi are shown in Figure 1 with their names and action mechanisms listed in Table 1 .…”

Section: Chemical Epigenetic Modifiers and Their Action Mechanismsmentioning

confidence: 99%

“…Many natural products were screened to have proteasome regulatory activities. However, they were rarely used for the regulation of fungal secondary metabolism [ 18 , 20 ]. The structures of compounds 471 – 475 isolated from fungi treated with proteasome modifier bortezomib are shown in Figure S14 .…”

Section: Effects Of Other Chemical Epigenetic Modifiersmentioning

confidence: 99%

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Recent Advances in Search of Bioactive Secondary Metabolites from Fungi Triggered by Chemical Epigenetic Modifiers

Xue

Hou

et al. 2023

JoF

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Genomic analysis has demonstrated that many fungi possess essential gene clusters for the production of previously unobserved secondary metabolites; however, these genes are normally reduced or silenced under most conditions. These cryptic biosynthetic gene clusters have become treasures of new bioactive secondary metabolites. The induction of these biosynthetic gene clusters under stress or special conditions can improve the titers of known compounds or the production of novel compounds. Among the inducing strategies, chemical-epigenetic regulation is considered a powerful approach, and it uses small-molecule epigenetic modifiers, which mainly act as the inhibitors of DNA methyltransferase, histone deacetylase, and histone acetyltransferase, to promote changes in the structure of DNA, histones, and proteasomes and to further activate cryptic biosynthetic gene clusters for the production of a wide variety of bioactive secondary metabolites. These epigenetic modifiers mainly include 5-azacytidine, suberoylanilide hydroxamic acid, suberoyl bishydroxamic acid, sodium butyrate, and nicotinamide. This review gives an overview on the method of chemical epigenetic modifiers to trigger silent or low-expressed biosynthetic pathways to yield bioactive natural products through external cues of fungi, mainly based on the research progress in the period from 2007 to 2022. The production of about 540 fungal secondary metabolites was found to be induced or enhanced by chemical epigenetic modifiers. Some of them exhibited significant biological activities such as cytotoxic, antimicrobial, anti-inflammatory, and antioxidant activity.

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Section: Discussionmentioning

confidence: 99%

Section: Chemical Epigenetic Modifiers and Their Action Mechanismsmentioning

confidence: 99%

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Recent Advances in Search of Bioactive Secondary Metabolites from Fungi Triggered by Chemical Epigenetic Modifiers

Xue

Hou

et al. 2023

JoF

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“…After the degradation of the protease structure, the protein is partitioned into peptides with a length of about approximately 7–8 amino acids. These peptides can be further degraded into single amino acid molecules and then used to synthesize new proteins [ 39 , 40 ]. Photosynthesis can fix carbon, and sugars are synthesized through light cooperation.…”

Section: Discussionmentioning

confidence: 99%

Integrated Omics Approach to Discover Differences in the Metabolism of a New Tibetan Desmodesmus sp. in Two Types of Sewage Treatments

Wang

Chen

Zhang³

et al. 2023

Metabolites

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Microalgae are now widely applied in municipal (YH_3) and industrial sewage (YH_4) treatments. Through integrated omics analysis, we studied the similarities and differences at the molecular level between the two different types of sewage treatment processes. The most significantly enriched gene ontology (GO) terms in both types of sewage treatments were the ribosome, photosynthesis, and proteasome pathways. The results show that the pathways of differentially expressed genes (DEGs) and differentially accumulated metabolites (DAMs) were enriched for photosynthesis, glyoxylate and dicarboxylate metabolism, and carbon fixation in photosynthetic organisms. Considering YH_3 vs. YH_4, the metabolism of citrate, sedoheptulose-7P, and succinate was significantly upregulated. In addition, the results showed that the pathways of DEGs and DAMs were enriched in terms of amino acid metabolism and carotenoid biosynthesis in YH_4 vs. YH_3. The metabolism of S-Adenosyl-L-homocysteine was significantly downregulated, 2-oxobutanoate was significantly upregulated and downregulated, and the metabolism of abscisic acid glucose ester (ABA-GE) was also significantly upregulated. Overall, the results of this paper will help to improve the basic knowledge of the molecular response of microalgae to sewage treatments, and help design a response strategy based on microalgae for complex, mixed sewage treatments.

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“…For instance, between 1981 and 2014, about 26% of new chemical entities were natural products or derived from natural products [5]. They are widely used in the prevention and treatment of clinical diseases as they have the unique advantages of low toxicity and side effects compared with chemical drugs [6]. Among medicinal plants, Clusiaceae contains approximately 50 genera and 600 species [7], and has been extensively used in ethnomedicine to treat a number of disease conditions, including wounds, ulcers, dysentery, cancer, inflammation, and infection [8,9].…”

Section: Introductionmentioning

confidence: 99%

Pharmacological Activity of Garcinia indica (Kokum): An Updated Review

Lim

Lee

et al. 2021

Pharmaceuticals

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Garcinia indica (commonly known as kokum), belonging to the Clusiaceae family (mangosteen family), is a tropical evergreen tree distributed in certain regions of India. It has been used in culinary and industrial applications for a variety of purposes, including acidulant in curries, pickles, health drinks, wine, and butter. In particular, G. indica has been used in traditional medicine to treat inflammation, dermatitis, and diarrhea, and to promote digestion. According to several studies, various phytochemicals such as garcinol, hydroxycitric acid (HCA), cyanidin-3-sambubioside, and cyanidin-3-glucoside were isolated from G. indica, and their pharmacological activities were published. This review highlights recent updates on the various pharmacological activities of G. indica. These studies reported that G. indica has antioxidant, anti-obesity, anti-arthritic, anti-inflammatory, antibacterial, hepatoprotective, cardioprotective, antidepressant and anxiolytic effects both in vitro and in vivo. These findings, together with previously published reports of pharmacological activity of various components isolated from G. indica, suggest its potential as a promising therapeutic agent to prevent various diseases.

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Natural products are an important source for proteasome regulating agents

Cited by 6 publications

References 145 publications

Recent Advances in Search of Bioactive Secondary Metabolites from Fungi Triggered by Chemical Epigenetic Modifiers

Recent Advances in Search of Bioactive Secondary Metabolites from Fungi Triggered by Chemical Epigenetic Modifiers

Integrated Omics Approach to Discover Differences in the Metabolism of a New Tibetan Desmodesmus sp. in Two Types of Sewage Treatments

Pharmacological Activity of Garcinia indica (Kokum): An Updated Review

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