Natural products applied against hydatid cyst protoscolices: A review of past to present

Kohansal, Mohammad Hasan; Nourian, Abbasali; Rahimi, Mohammad Taghi; Daryani, Ahmad; Spotin, Adel; Ahmadpour, Ehsan

doi:10.1016/j.actatropica.2017.09.013

Cited by 54 publications

(43 citation statements)

References 80 publications

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“…For example, adverse side effects have been reported for 20% hypertonic saline, 20% silver nitrate, 0.5-1% cetrimide, ethyl alcohol and 20 mg/mL albendazole sulfoxide. 10 The elimination of protoscolices with scolicidal agents, associated with high efficacy and minimum side effects, have been suggested as an alternative to opening or removing cysts. 13 Moreover, chemotherapy can be applied for patients who are not proper candidates for surgery; it can be also applied as a complementary treatment to surgery (before surgery, after surgery or both).…”

Section: Discussionmentioning

confidence: 99%

“…Gold nanoparticles at the concentration of 1 mg/mL led to killing all protoscoleces at 60 mins. 23 The scolicidal effect of green synthesized silver NPs at different concentrations (0.025, 0.05, 0.1 and 0.15 mg/mL) and different exposure times (10,30,60 and 120 min) against protoscolices of CHD were previously investigated. 24 The findings showed that the Ag-NPs at all concentrations had high scolicidal effects.…”

Section: Discussionmentioning

confidence: 99%

“…Use of effective scolicidal agents during hydatid cyst surgery is essential to prevent the secondary infection. 10 Although the production of nanosized particles had occurred in several ways in ancient times and hundred years ago, nanomedicine as a modern science was first confirmed in the 1990s of the last century only. 11 This study was conducted for the first time to determine the scolicidal effect of silver, iron, copper, silicon and zinc oxides nanoparticles in vitro.…”

Section: Introductionmentioning

confidence: 99%

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<p>Scolicidal Effects of Nanoparticles Against Hydatid Cyst Protoscolices in vitro</p>

Norouzi¹,

Ataei²,

Hejazy³

et al. 2020

IJN

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Background: Echinococcus granulosus is causative agent of cystic echinococcosis (CE), which has a cosmopolitan distribution. The current methods for the treatment of human CE include surgery. Therefore, the development of new scolicidal agents with low side effects and more efficacies is an urgent need. Purpose: The present study aimed to compare the scolicidal efficacies of silver, iron, copper, silica and zinc oxide nanoparticles (NPs) against hydatid cyst protoscolices in vitro. Methods: Hydatid cysts of sheep liver and lung were collected. The cyst fluid containing protoscolices was aspirated aseptically. The scolicidal activities of the silver, iron, copper, silica and zinc nanoparticles (Ag-NP, Fe-NP, Cu-NP, Si-NP and Zn-NP) were tested at different concentrations of 0.25, 0.5 and 1 mg/mL following 10, 30 and 60 min of incubation in triplicate. Viability of protoscolices was confirmed by 0.1% eosin staining. Results: Results showed that Ag-NPs at all concentrations tested had the highest scolicidal effect. Ag-NPs at 1 mg/mL concentration after 60 min of exposure time showed 80% mortality rate. Si-NPs had the high scolicidal activity at 1 mg/mL concentration (52.33%), Cu-NPs at 0.5 mg/mL concentration (41%), Fe-NPs at 1mg/mL concentration (28%) and Zn-NPs at concentration of 1mg/mL after 60 mins (15.67%). Conclusion: The findings of the present study showed that Ag-NPs, Fe-NPs, Cu-NPs, Si-NPs and Zn-NPs had potent scolicidal effects and that Ag-NPs are recommended as effective scolicidal agents. However, further in vivo studies are required to evaluate the efficacy of these nanoparticles.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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<p>Scolicidal Effects of Nanoparticles Against Hydatid Cyst Protoscolices in vitro</p>

Norouzi¹,

Ataei²,

Hejazy³

et al. 2020

IJN

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“…Although the cell death process is an answer to the question of how to determine the fate of dead cells, most of the interactions between Echinococcus and host tissues are associated with immune and pathologic conditions. The lack of satisfactory treatment for echinococcosis and the emergence of resistance to existing antibiotics [4,19,44] may raise the following question: is RCD a gateway to this parasite? Studies of the suicide genes involved in these pathways and the effects of various factors on their activity can help to identify new pharmacologic targets and improve treatment.…”

Section: Resultsmentioning

confidence: 99%

Interactions between hydatid cyst and regulated cell death may provide new therapeutic opportunities

2019

Self Cite

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Cystic echinococcosis and alveolar echinococcosis are chronic zoonotic infections, transmitted throughout the world. Development of the cestode larval stages in the liver and lungs causes damage to intermediate hosts, including humans. Several pathways leading to the suppression of host immune response and the survival of the cysts in various hosts are known. Immune response modulation and regulated cell death (RCD) play a fundamental role in cyst formation, development and pathogenesis. RCD, referring to apoptosis, necrosis and autophagy, can be triggered either via intrinsic or extrinsic cell stimuli. In this review, we provide a general overview of current knowledge on the process of RCD during echinococcosis. The study of interactions between RCD and Echinococcus spp. metacestodes may provide in-depth understanding of echinococcosis pathogenesis and open new horizons for human intervention and treatment of the disease.

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“…Hydatid cyst disease is parasitic disease common in humans and ruminants and is a health and economic problem in most parts of the world. 1 Hydatidosis is particularly prevalent in rural areas where cattle, especially sheep and dogs, are abundant. The parasite needs to complete its life cycle to a host of sheep, goats, camels, pigs, horses, donkeys, monkeys and other animals of the platoon to survive alive.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Aloe Vera Extracts on the Viability of Echinococcus Granulosus Protoscolices

Arabi¹,

Mehdi²,

Farooqui³

et al. 2019

Int. Res. J. Pharm.

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The study included the preparation of alcohol and aqueous extracts of Aloe Vera leaves at concentrations 50-75-100 mg / ml to study the effect of the viability protoscolices of the parasitic Echinococcus granolosus in vitro and their growth in vitro in order to reach an effective focus in killing the protoscolices during the shortest period of time. The results showed a significant decrease in the treatment of the alcoholic and aqueous extracts Aloe Vera leaves. Total killings for protoscolices at 100 mg / ml at 24 hours followed by concentration 75 and 50 mg / ml at 48 hours exposure period.

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Natural products applied against hydatid cyst protoscolices: A review of past to present

Cited by 54 publications

References 80 publications

<p>Scolicidal Effects of Nanoparticles Against Hydatid Cyst Protoscolices in vitro</p>

<p>Scolicidal Effects of Nanoparticles Against Hydatid Cyst Protoscolices in vitro</p>

Interactions between hydatid cyst and regulated cell death may provide new therapeutic opportunities

The Effect of Aloe Vera Extracts on the Viability of Echinococcus Granulosus Protoscolices

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