Interactions between hydatid cyst and regulated cell death may provide new therapeutic opportunities

Moghaddam, Sirous Mehrani; Picot, Stéphane; Ahmadpour, Ehsan

doi:10.1051/parasite/2019070

Cited by 11 publications

(5 citation statements)

References 57 publications

(59 reference statements)

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“…Bcl-2-specific siRNA incorporated into a multiprotein RNA-inducing silencing complex (RISC) (3). The RISC attached to complementary target mRNA (4) and subsequent endonucleolytic cleavage and gene silencing (5) regarding the regulatory role of inhibitors of apoptotic proteins through the development of E. granulosus [67,68].…”

Section: Can Sirna and Anti-apoptotic Adjuvants Be Regarded As Therap...mentioning

confidence: 99%

Recent advances on innate immune pathways related to host–parasite cross-talk in cystic and alveolar echinococcosis

et al. 2020

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Cystic echinococcosis (CE) and alveolar echinococcosis (AE) are life-threatening parasitic infections worldwide caused by Echinococcus granulosus (sensu lato) and E. multilocularis, respectively. Very little is known about the factors affecting innate susceptibility and resistance to infection with Echinococcus spp. Although benzimidazolic drugs against CE and AE have definitively improved the treatment of these cestodes; however, the lack of successful control campaigns, including the EG95 vaccine, at a continental level indicates the importance of generating novel therapies. This review represents an update on the latest developments in the regulatory functions of innate immune pathways such as apoptosis, toll-like receptors (TLRs), and inflammasomes against CE and AE. We suggest that apoptosis can reciprocally play a bi-functional role among the host-Echinococcus metabolite relationships in suppressive and survival mechanisms of CE. Based on the available information, further studies are needed to determine whether the orchestrated in silico strategy for designing inhibitors and interfering RNA against anti-apoptotic proteins and TLRs would be effective to improve new treatments as well as therapeutic vaccines against the E. granulosus and E. multilocularis.

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Section: Can Sirna and Anti-apoptotic Adjuvants Be Regarded As Therap...mentioning

confidence: 99%

Recent advances on innate immune pathways related to host–parasite cross-talk in cystic and alveolar echinococcosis

et al. 2020

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“…The results of the current study revealed that the hydatid cysts in the infected mice were sterile. Numerous investigations have demonstrated that apoptosis-inducing factors are expressed at higher levels in the germinal layer of sterile cysts than in fertile cysts, and anti-apoptotic materials are expressed at higher rates in fertile cysts, which may have an impact on hydatid cyst infertility (Moghaddam et al, 2019). Inflammatory CD3+ T cells and CD19+ B cells were the two most common inflammatory cells in all groups.…”

Section: Advances In Animal Andmentioning

confidence: 87%

“…For a deeper understanding of the interaction between the host and the parasite as well as the variables that affect this interaction, research into the pathologic pathways of cell death is also crucial. In particular, in the liver and lungs, factors that affect the enzyme activity in hydatid cysts can cause cystic infertility and stop the spread of the disease (Moghaddam et al, 2019).…”

Section: Advances In Animal Andmentioning

confidence: 99%

Immunohistochemical and Histopathological Characterization of Immune Changes in the Host-tissue Reaction site of Murine Cystic Echinococcosis

Hamad¹,

Shnawa²,

Alrawi³

2022

AAVS

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C ystic echinococcosis (CE) is a zoonotic infection caused by the dog tapeworm Echinococcus granulosus metacestodes. The World Health Organization listed it as one of the twenty neglected tropical diseases (WHO, 2010). It is a significant helminthic disease, representing worldwide public health and socioeconomic concern (Wen et al., 2019). The life cycle of Echinococcus involves a defin-itive host (usually dogs and other carnivores) and an intermediate host (such as sheep, goats, or cattle). Humans act as accidental intermediate hosts since they acquire the infection like other intermediate hosts; however, they are not involved in transmitting the parasite to the definitive host (Shnawa et al., 2022a). The liver is the organ that is most frequently impacted by hydatid cysts (50-70%), followed by the lungs (25%), spleen, kidneys, heart, bones, CNS, viscera, and other organs (Kammerer and Schantz, 1993,

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“…It is accepted that apoptosis played a binary role in the association between host and cystic echinococcosis (CE) in the mechanisms of survival and/or suppression [ 27 , 28 ]. Generally, caspase enzymes play a significant role in apoptotic progression.…”

Section: Discussionmentioning

confidence: 99%

Scolicidal and Apoptotic Activities of 5-hydroxy-1, 4-naphthoquinone as a Potent Agent against Echinococcus granulosus Protoscoleces

et al. 2021

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Cystic hydatid disease (CHD) is a zoonotic disease with different clinical stages caused by the larval stage of the cestode Echinococcus granulosus. It is important to highlight as a public health problem in various regions of the world. In the current study, the efficacy and apoptotic activity of the liposomal system containing juglone (5-hydroxy-1,4-naphthoquinone) were assessed against protoscoleces (PSCs) in vitro. To this aim, firstly, liposomal vesicles were prepared by the thin-film method. Their physico-chemical features were assessed using Zeta-Sizer and Scanning Electron Microscope (SEM). Subsequently, various concentrations (50, 100, 200, 400, and 800 μg/mL) of juglone nanoliposomes at different exposure times (15, 30, 60, and 120 min) were used against PSCs. Results showed that juglone nanoliposomes at all tested concentrations induced scolicidal effect, however, 800 μg/mL and 400 μg/mL of juglone nanoliposomes could reach 100% mortality in 60 and 120 min, respectively. Additionally, we found that caspase-3 mRNA expression was higher in PSCs treated with juglone nanoliposomes compared to control groups (p < 0.001). Therefore, juglone nanoliposomes are suggested to have a more potent apoptotic effect on PSCs. Generally, optimized doses of juglone nanoliposomes could display significant scolicidal effects. Moreover, further in vivo studies are required to evaluate the efficacy of this nanoliposome.

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Interactions between hydatid cyst and regulated cell death may provide new therapeutic opportunities

Cited by 11 publications

References 57 publications

Recent advances on innate immune pathways related to host–parasite cross-talk in cystic and alveolar echinococcosis

Recent advances on innate immune pathways related to host–parasite cross-talk in cystic and alveolar echinococcosis

Immunohistochemical and Histopathological Characterization of Immune Changes in the Host-tissue Reaction site of Murine Cystic Echinococcosis

Scolicidal and Apoptotic Activities of 5-hydroxy-1, 4-naphthoquinone as a Potent Agent against Echinococcus granulosus Protoscoleces

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