Natural Product Dietary Supplement Use by Individuals With Rheumatoid Arthritis: A Scoping Review

DeSalvo, Janel; Skiba, Meghan B; Howe, Carol; Haiber, Karen; Funk, Janet L.

doi:10.1002/acr.23696

Cited by 17 publications

(11 citation statements)

References 35 publications

(117 reference statements)

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“…Therefore, it is not surprising that the interest of scientists has been caught by complementary and different therapeutic strategies, specifically compounds of natural origin and nutraceuticals, which have gained interest in the management of RA, especially in elderly patients [24,25,26]. In fact, a growing number of patients seek remedy in natural compounds, because they believe that they are effective and safe [27,28].…”

Section: Discussionmentioning

confidence: 99%

β-Caryophyllene Mitigates Collagen Antibody Induced Arthritis (CAIA) in Mice Through a Cross-Talk between CB2 and PPAR-γ Receptors

et al. 2019

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β-caryophyllene (BCP) is a cannabinoid receptor 2 (CB2) agonist that tempers inflammation. An interaction between the CB2 receptor and peroxisome proliferator-activated receptor gamma (PPAR-γ) has been suggested and PPAR-γ activation exerts anti-arthritic effects. The aim of this study was to characterize the therapeutic activity of BCP and to investigate PPAR-γ involvement in a collagen antibody induced arthritis (CAIA) experimental model. CAIA was induced through intraperitoneal injection of a monoclonal antibody cocktail and lipopolysaccharide (LPS; 50 μg/100 μL/ip). CAIA animals were then randomized to orally receive either BCP (10 mg/kg/100 μL) or its vehicle (100 μL of corn oil). BCP significantly hampered the severity of the disease, reduced relevant pro-inflammatory cytokines, and increased the anti-inflammatory cytokine IL-13. BCP also decreased joint expression of matrix metalloproteinases 3 and 9. Arthritic joints showed increased COX2 and NF-ĸB mRNA expression and reduced expression of the PPARγ coactivator-1 alpha, PGC-1α, and PPAR-γ. These conditions were reverted following BCP treatment. Finally, BCP reduced NF-ĸB activation and increased PGC-1α and PPAR-γ expression in human articular chondrocytes stimulated with LPS. These effects were reverted by AM630, a CB2 receptor antagonist. These results suggest that BCP ameliorates arthritis through a cross-talk between CB2 and PPAR-γ.

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Section: Discussionmentioning

confidence: 99%

β-Caryophyllene Mitigates Collagen Antibody Induced Arthritis (CAIA) in Mice Through a Cross-Talk between CB2 and PPAR-γ Receptors

et al. 2019

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“…8,[13][14][15][16][17] Biologically based therapies (eg, herbal products, special diets, megavitamins) were among the most frequently used CAM approaches in the 2002 and 2007 NHIS, 8,9,18,19 yet more evidence is warranted due to the broad scope and variety in this therapeutic category. 20 Although mind-body CAM approaches such as progressive muscle relaxation are less frequently used, 21 emerging evidence shows that such activities including tai chi, qi gong, and yoga may be effective in reducing pain and improving functionality in people with arthritis. 14 Acupuncture also has been found to be effective in improving pain and physical dysfunction in patients with OA.…”

Section: Introductionmentioning

confidence: 99%

Complementary and Alternative Medicine Use by U.S. Adults with Self‐Reported Doctor‐Diagnosed Arthritis: Results from the 2012 National Health Interview Survey

Zhang

Dennis

Bishop

et al. 2019

PM&R

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Background The use of complementary and alternative medicine (CAM) therapies have been reported for the management of arthritis. However, little is known about CAM use among adults with self‐reported doctor‐diagnosed arthritis. Objectives To determine (1) the prevalence and type of CAM use, (2) the difference in characteristics between CAM users and non‐CAM users, and (3) the factors related to CAM use, among U.S. adults with self‐reported doctor‐diagnosed arthritis. Design Secondary analysis of the 2012 National Health Interview Survey (NHIS) data. Setting The NHIS is a cross‐sectional survey that gathers health‐related data on the civilian, noninstitutionalized U.S. population. Participants The NHIS 2012 uses a complex, multistage sampling design and oversamples minorities to achieve population representation; it included 34 525 adults, with 7179 adults having arthritis. Methods Data were analyzed using Stata 15.1 survey syntax. The potential factors related to CAM use included sociodemographics and health‐related characteristics. Main Outcome Measurements CAM modalities were categorized into six groups: natural products, manipulative therapies, mind‐body therapies, special diets, movement therapies, and other practitioner‐based CAM modalities. Results Of the adults with arthritis, 2428 (weighted estimate of 36.2% of U.S. adult population) had used CAM within the last year. Adults with arthritis reported greater use of CAM than those without, particularly the use of natural products, manipulative therapies and other practitioner‐based CAM modalities. Factors associated with higher CAM use included being female, residing in regions other than the U.S. South, having a college degree or higher, reporting very good/excellent self‐rated health status, and having current symptoms of joint stiffness/pain. Conclusion As more than one‐third of U.S. adults with arthritis seek CAM therapies, open and nonjudgmental conversations between conventional medicine providers, CAM providers, and patients should be encouraged to ensure patient health care needs are being met. Level of Evidence III

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“…The evidence for the practical use of these substances is still scarce [ 162 ]. There is usually a lack of communication between doctors and patients using natural products for RA that can be prejudicial to the therapy [ 163 ].…”

Section: Advantages and Applications Of Various Marine-derived Commentioning

confidence: 99%

Marine-Derived Biologically Active Compounds for the Potential Treatment of Rheumatoid Arthritis

et al. 2020

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Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease with a prevalence rate of up to 1% and is significantly considered a common worldwide public health concern. Commercially, several traditional formulations are available to treat RA to some extent. However, these synthetic compounds exert toxicity and considerable side effects even at lower therapeutic concentrations. Considering the above-mentioned critiques, research is underway around the world in finding and exploiting potential alternatives. For instance, marine-derived biologically active compounds have gained much interest and are thus being extensively utilized to confront the confines of in practice counterparts, which have become ineffective for 21st-century medical settings. The utilization of naturally available bioactive compounds and their derivatives can minimize these synthetic compounds’ problems to treat RA. Several marine-derived compounds exhibit anti-inflammatory and antioxidant properties and can be effectively used for therapeutic purposes against RA. The results of several studies ensured that the extraction of biologically active compounds from marine sources could provide a new and safe source for drug development against RA. Finally, current challenges, gaps, and future perspectives have been included in this review.

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Natural Product Dietary Supplement Use by Individuals With Rheumatoid Arthritis: A Scoping Review

Cited by 17 publications

References 35 publications

β-Caryophyllene Mitigates Collagen Antibody Induced Arthritis (CAIA) in Mice Through a Cross-Talk between CB2 and PPAR-γ Receptors

β-Caryophyllene Mitigates Collagen Antibody Induced Arthritis (CAIA) in Mice Through a Cross-Talk between CB2 and PPAR-γ Receptors

Complementary and Alternative Medicine Use by U.S. Adults with Self‐Reported Doctor‐Diagnosed Arthritis: Results from the 2012 National Health Interview Survey

Marine-Derived Biologically Active Compounds for the Potential Treatment of Rheumatoid Arthritis

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