Marine-Derived Biologically Active Compounds for the Potential Treatment of Rheumatoid Arthritis

Abstract

Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease with a prevalence rate of up to 1% and is significantly considered a common worldwide public health concern. Commercially, several traditional formulations are available to treat RA to some extent. However, these synthetic compounds exert toxicity and considerable side effects even at lower therapeutic concentrations. Considering the above-mentioned critiques, research is underway around the world in finding and exploiting potential alternatives. For instance, marine-derived biologically active compounds have gained much interest and are thus being extensively utilized to confront the confines of in practice counterparts, which have become ineffective for 21st-century medical settings. The utilization of naturally available bioactive compounds and their derivatives can minimize these synthetic compounds’ problems to treat RA. Several marine-derived compounds exhibit anti-inflammatory and antioxidant properties and can be effectively used for therapeutic purposes against RA. The results of several studies ensured that the extraction of biologically active compounds from marine sources could provide a new and safe source for drug development against RA. Finally, current challenges, gaps, and future perspectives have been included in this review.

Food-derived bioactive peptides potentiating therapeutic intervention in rheumatoid arthritis

“…However, some patients could develop more serious problems such as a resurgence of previous infections like tuberculosis. Many concerns emerge about possible increases in cardiovascular risk and disease occurrence [ 123 , 124 ]. It is obvious from these conventional treatment options that a more sustainable, much safer, and perhaps food-derived alternative therapy is warranted for treating or managing RA.…”

Adjuvant benefit of a peptide-rich marine biology formula (LD- 1227) in rheumatoid arthritis: a randomized, double-blind, controlled study

“…While phytocompounds have indeed been largely analyzed and under scrutiny, there are only a few, but promising reports on marine biology-derived compounds in the treatment of RA [26][27][28][29][30]. Very recently, a study using a marine extract in RA has shown a benefit effect on inflammatory pathways [31]. About 10 years ago, we had shown that a specific proprietary marine lipoprotein, fish DNA extracts and peptides-rich compound, LD-1227 (Caviarlieri, Lab-Dom, Switzerland) could significantly inhibit IL-1β-induced proliferation and inflammatory reactions by partly inhibiting the transcription factor NF-κB pathway in human chondrocytes ex-vivo derived from osteo-arthritis patients [32].…”