2021
DOI: 10.1016/j.ijbiomac.2021.10.074
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Natural polysaccharides based self-assembled nanoparticles for biomedical applications – A review

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Cited by 57 publications
(27 citation statements)
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References 139 publications
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“…Four out of six polysaccharide nanoparticles (F2, F3, F4, and F5) exhibited significant antiviral activity against the influenza virus H1N1. Natural polysaccharides have been widely adopted for the fabrication of nanoparticles due to their advantages on low toxicity, low immunogenicity, good biocompatibility, and so on [ 40 ]. The polysaccharide nanoparticles have high efficiency in delivering substances and the potential on targeted delivery due to the specific binding ability to cell surface markers of several types of polysaccharides such as hyaluronic acid and pullulan [ 41 , 42 ].…”
Section: Discussionmentioning
confidence: 99%
“…Four out of six polysaccharide nanoparticles (F2, F3, F4, and F5) exhibited significant antiviral activity against the influenza virus H1N1. Natural polysaccharides have been widely adopted for the fabrication of nanoparticles due to their advantages on low toxicity, low immunogenicity, good biocompatibility, and so on [ 40 ]. The polysaccharide nanoparticles have high efficiency in delivering substances and the potential on targeted delivery due to the specific binding ability to cell surface markers of several types of polysaccharides such as hyaluronic acid and pullulan [ 41 , 42 ].…”
Section: Discussionmentioning
confidence: 99%
“…Observa-se na literatura científica vários modos de auto-montagem de polissacarídeos naturais, onde estes polímeros apresentam vantagens como biodegradabilidade, baixa toxicidade e propriedades degradáveis. A aplicação de ácido chitosano, ácido hialurônico, alginato, amido e seus derivados tem sido extensivamente estudada, especialmente nos campos biomédicos (FAN et al, 2021). As nanopartículas baseadas em polissacarídeos naturais mostraram melhorar a solubilidade de drogas insolúveis, aumentar a capacidade de alvo do tecido e realizar a liberação controlada e sustentada de drogas.…”
Section: Aplicações De Polissacarídeosunclassified
“…Outras forças impulsionadas da auto-montagem incluem interação eletrostática e ligações de hidrogênio. Até o momento, as nanopartículas à base de polissacarídeos têm sido amplamente aplicadas para tratamento tumoral, aplicação antibacteriana, terapia genética, terapia fotodinâmica e transporte de insulina (FAN et al, 2021) O ácido hialurônico (Figura 7) é um mucopolissacarídeo linear, glicosaminoglicano não sulfato, de elevada massa molecular, composto por unidades de ácido D-glicurônico e N-acetil glucosamina unidas, alternadamente por ligações glicosídicas β-1,3 e β-1,4. O ácido hialurônico está presente na matriz extracelular dos seres humanos, presente nos corpos vítreos dos seres vivos, cordão umbilical e no fluido sinovial.…”
Section: Aplicações De Polissacarídeosunclassified
“…Polysaccharide-based nanoparticles (PNPs) have been of increased interest recently as tools in biomedicine due to numerous advantages, including affordability, accessibility, safety, good storage stability, hydrophilicity, and nontoxicity. , More importantly, the use of PNPs in practically all living species does not result in hazardous effects to the organisms due to their inherent biocompatibility and biodegradability . Consequentially, recent years have seen a rise in interest in studies of the biological impacts of polysaccharides and the creation of new PNPs.…”
Section: Introductionmentioning
confidence: 99%