Natural polysaccharide functionalized gold nanoparticles as biocompatible drug delivery carrier

Pooja, Deep; Panyaram, Sravani; Kulhari, Hitesh; Reddy, B Vinod Kumar N Harish; Rachamalla, Shyam Sunder; Sistla, Ramakrishna

doi:10.1016/j.ijbiomac.2015.06.022

Cited by 119 publications

(60 citation statements)

References 36 publications

(34 reference statements)

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“…The NPs with an average diameter of 15-20 nm demonstrated very low hemolytic toxicity of 1.4% at the highest tested concentration of 250 μg/mL. The cell cytotoxicity studies also indicated to the biocompatibility of the gum synthesized AuNPs, which was associated with the presence of GK on the surface of the AuNPs [158]. Similar low toxicity reported for xanthan-mediated AuNPs [159].…”

Section: Toxicity Of Polysaccharide-based Aunpssupporting

confidence: 69%

Green synthesis of polysaccharide-based inorganic nanoparticles and biomedical aspects

Shavandi¹,

Saeedi

Ali

et al. 2019

Functional Polysaccharides for Biomedical Applications

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Section: Toxicity Of Polysaccharide-based Aunpssupporting

confidence: 69%

Green synthesis of polysaccharide-based inorganic nanoparticles and biomedical aspects

Shavandi¹,

Saeedi

Ali

et al. 2019

Functional Polysaccharides for Biomedical Applications

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“…At present, current cancer therapies consist of agents that target signaling pathways involved in cell proliferation, which result in cell death, for example, gemcitabine hydrochloride (18). However, further investigation into the mechanisms involved in cancer development is required in order to develop novel and improved anti-cancer therapies.…”

Section: Discussionmentioning

confidence: 99%

RhoA inhibits apoptosis and increases proliferation of cultured SPCA1 lung cancer cells

Liu

Mei

Wang

et al. 2017

Molecular Medicine Reports

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The Rho kinase pathway has previously been reported to possess a close relationship with the growth, migration and invasion of lung cancer cells. However, the molecular mechanisms underlying the effects of this pathway on lung cancer cells are still elusive. The aim of the present study was to investigate the effects and underlying molecular mechanisms of Ras homolog family member A (RhoA) on the proliferation and apoptosis of SPCA1 lung carcinoma cells. Stable SPCA1 lung cancer cell lines, in which RhoA expression was silenced by small interfering RNA, were isolated following Geneticin screening. Inhibition of RhoA expression significantly decreased the proliferation of SPCA1 lung cancer cells, whereas apoptosis was significantly increased (P<0.01) as determined by the MTS tetrazolium assay and flow cytometry analysis, respectively. At the molecular level, knockdown of RhoA resulted in the significant activation of caspase-3 (P<0.01), and a significant reduction in the levels of phosphorylated signal transducer and activator of transcription (phospho-STAT3; P<0.01), as determined by western blotting. The results suggested that RhoA knockdown prevents cell proliferation and induces apoptosis in SPCA1 lung cancer cells. Furthermore, the underlying mechanisms responsible for these effects may include the activation of caspase-3 and the reduction of phospho-STAT3 levels.

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“…It has also been proven that nanoparticles alone can enhance the effects of medicinal substances and act as active compounds themselves. It is important that nanoparticles remain stable throughout treatment and that nanoparticle size does not exceed 100 nm to avoid opsonization and subsequent elimination from the immune system [39]. Both gold and silver nanoparticles may also have some disadvantages, in particular the possibility of releasing metal ions into the environment, which affects their cytotoxicity.…”

Section: Metal Nanoparticles As Drug Carriersmentioning

confidence: 99%

Methods for Reducing the Toxicity of Metal and Metal Oxide NPs as Biomedicine

et al. 2020

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The rapid development of medicine has forced equally rapid progress in the field of pharmaceuticals. In connection with the expensive and time-consuming process of finding new drugs, great emphasis is put on the design and use of metal and metal oxides nanoparticles in nanomedicine. The main focus is on comprehensive presentation of both physicochemical properties and the possibilities of using, in particular, silver (Ag) and gold (Au) nanoparticles, as well as zinc oxide (ZnO) and titanium oxide (TiO2) nanoparticles as drug carriers and in the treatment of cancer. An important element of this subject is the possibility of occurrence of toxic effects of these nanoparticles. For this reason, possible mechanisms of toxic actions are presented, as well as methods used to reduce their toxicity to ensure the safety of drug carriers based on these nanostructures.

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Natural polysaccharide functionalized gold nanoparticles as biocompatible drug delivery carrier

Cited by 119 publications

References 36 publications

Green synthesis of polysaccharide-based inorganic nanoparticles and biomedical aspects

Green synthesis of polysaccharide-based inorganic nanoparticles and biomedical aspects

RhoA inhibits apoptosis and increases proliferation of cultured SPCA1 lung cancer cells

Methods for Reducing the Toxicity of Metal and Metal Oxide NPs as Biomedicine

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