Natural Polymer Vis a Vis Synthetic Polymer for Solubility Enhancement of Simvastatin

Abstract

Preparation of co-grinding mixture 22 Co-grinded mixture of drug and polymers were prepared in different ratio such as 1:1 to 1:9 w/ w. It was co-grinded for 5min, in ceramic mo rtar and sieved through 100 # mesh. ABS TRACT The enhancement of the oral bioavailability is currently one of the greatest challenges in the development of poorly water soluble drugs. The main objective of work to enhance solubility of Simvastatin (SIM) by use of natural polymer, chitosan (CHI) and Hydroxy propyl methyl cellulose E3LV (HPM CE3LV), synthetic polymer to produce cost effective formulation. Physical mixture, co-grinding method, spray drying method are compared for solubility enhancement of simvastatin. It is found that co-grinding method is best for solubility enhancement of simvastatin.Co-grinding method applied for preparation of drug polymer complex and compared with the solubility and dissolution of marketed preparation.