Natural Polymer Based Mucoadhesive Hydrogel Beads of Nizatidine: Preparation, Characterization and Evaluation.

Abstract

Background: Dosage forms which precisely control the release rates and targets drugs to a specific body site have made enormous impact in the formulation and development of novel drug delivery systems. Methods: A prolonged release mucoadhesive hydrogel system of nizatidine was prepared by ionotropic gelation and polyelectrolyte complexation technique using natural, biodegradable polymers with or without chitosan. Prepared formulations were subjected to in vitro evaluation and several characterization studies. Results: Formulations with chitosan showed good drug content, swelling index and mucoadhesive strength when compared to batches containing alginate alone. The drug in formulations found to be intact and compatible with polymers used and surface morphology of prepared beads were found satisfactory. Two optimized formulations containing alginatechitosan shows Higuchi model and perfect zero order release. All the formulations with copolymer showed better sustained the drug release when compared with formulations without chitosan. Conclusion: Alginate-chitosan beads prepared by ionotropic geltion and polyelectrolyte complexation method found to be better than ionically cross linked alginate beads alone. Therefore, dual cross-linked beads are promising carrier for oral control release.

How the combination of alginate and chitosan can fabricate a hydrogel with favorable properties for wound healing

“…Despite alginate, chitosan exhibits remarkable adhesive properties. Hydrogels composed of chitosan-alginate, which act as a coating for a drug core, as reported by Patil et al (2016) , display superior mucoadhesive characteristics compared to dressings without chitosan [ 54 , 75 ]. However, pure chitosan is not appropriate for cell attachment studies due to its cationic nature.…”

α-Mangostin Hydrogel Film Based Chitosan–Alginate for Recurrent Aphthous Stomatitis

“…It was reported that the formation of hydrogels using Alg and Ch can be achieved by adjusting the pH of the mixing solution without adding calcium cations [12,13]. Patil et al proved that hydrogel based on Ch-Alg formulations had a higher mucoadhesive strength compared to hydrogel based on Alg [14]. In addition, Ch molecular weight in Ch-Alg polyelectrolyte complex film containing clindamycin phosphate affected to adhesiveness of complex films [15].…”

Synthesis and Characterisation of Biodegradable Carboxymethyl Cellulose Microcarriers from Oil Palm Empty Fruit Bunch for Therapeutic Applications

“…microcarrier(Zakiah et al, 2015) (Sathali and Varun, 2012). The swelling of CMC-microcarriers was governed by the degree of crosslinking, with greater cross-linkages reducing the swelling due to limited space available for the diffusion of free water into the polymer network (CheNan et al, 2019;Patil et al, 2016;Tuan Mohamood et al, 2021). Lower S w was found in samples with higher gel content percentages (CMC-3, CMC-6, and CMC-9), while S w value rose in samples with low gel content (CMC-1, CMC-4, and CMC-7).…”