Natural plant polyphenols for alleviating oxidative damage in man: Current status and future perspectives

Li, Jiaokun; Liu, Xue-Duan; Шен, Ли; Zeng, Weimin; Qiu, Guanzhou

doi:10.4314/tjpr.v15i5.27

Cited by 28 publications

(17 citation statements)

References 74 publications

(88 reference statements)

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“…Natural phenolic compounds have beneficial effects on human health by protecting against oxidative stress-related chronic diseases [ 35 ]. Recent studies reported that phenolic extracts derived from rice bran have anti-oxidant potential by upregulating the expression of nuclear factor erythroid 2–related factor 2 (Nrf2) under oxidative stress conditions [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

In Vivo and In Vitro Effects of Tracheloside on Colorectal Cancer Cell Proliferation and Metastasis

et al. 2021

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Recent research suggests a relationship between cancer progression and oxidative mechanisms. Among the phenolic compounds such as tracheloside (TCS) are a major bioactive compound that can combat oxidant stress-related chronic diseases and that also displays anti-tumor activity. Although TCS can inhibit mammalian carcinoma, its effects on colorectal cancer (CRC) have not been clarified. The purpose of this study was to investigate the effects of TCS on the proliferation of CRC cells, the metastasis of CT26 cells, and the molecular mechanisms related to TCS in vitro and in vivo. A cell viability assay showed that TCS inhibited the proliferation of CRC cells. TCS-treated CT26 cells were associated with the upregulation of p16 as well as the downregulation of cyclin D1 and CDK4 in cell cycle arrest. In addition, TCS induced apoptosis of CT26 cells through mitochondria-mediated apoptosis and regulation of the Bcl-2 family. Expression of epithelial–mesenchymal transition (EMT) markers was regulated by TCS treatment in CT26 cells. TCS significantly inhibited the lung metastasis of CT26 cells in a mouse model. These results suggest that TCS, by inducing cell cycle arrest and apoptosis through its anti-oxidant properties, is a novel therapeutic agent that inhibits metastatic phenotypes of murine CRC cells.

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Section: Discussionmentioning

confidence: 99%

In Vivo and In Vitro Effects of Tracheloside on Colorectal Cancer Cell Proliferation and Metastasis

et al. 2021

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“…It is well established that by-products of oxygen metabolism produce free radicals such as reactive oxygen and nitrogen species which results to cellular damage and pathogenesis of several diseases such as cancer, cardiovascular diseases, diabetes, neurodegenerative diseases among others (Li et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…The roles of phenolic compounds from medicinal plants as supplement in the treatment of oxidative stress and free radicals mediated tissue damage cannot the overemphasized (Li et al, 2016). Flavonoids and phenolic acids from polyphenols have been reported to play a significant role in scavenging free radicals and prevention of oxidative damage to cells.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Activities of the Leaf Extract and Fractions of Dryopteris filix-mas (L.) Schott could be Attributed to The Abundance of Polyphenol Compounds

et al. 2020

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Dryopteris filix mas (D filix-mas) is wildly used in ethnomedicine for the management of rheumatoid arthritis, wounds and other diseases. We investigated the anti-oxidant activities of its leaf extract, and chromatographic fractions. The ethanol leaf extract was partitioned into four fractions; n-hexane, ethyl acetate, n-butanol and water. Ferric reducing anti-oxidant power (FRAP), 1, 1-diphenyl-2-picrylhydrazil (DPPH) and nitric oxide (NO) scavenging in vitro assays were carried out on the extract and fractions at 6.25, 12.5, 25, 50, 100, 200, 400 and 800 µg/mL. The most active fraction (ethyl acetate fraction) was further purified using chromatographic techniques to isolate its major compound whose structure was elucidated using ID nuclear magnetic resonance (NMR) and mass spectrometry. The ethyl acetate fraction produced the highest free radical scavenging activity among the other fractions. The fraction (VLC-E7) from which the bioactive compound, quercetin-3-O-αL-rhamnopyranoside, was isolated had the best FRAP and DPPH scavenging activities with EC50 and IC50 values of 88.81 ± 3.41 and 26.87 ± 0.24 respectively more than the ethyl acetate fraction. This study revealed that the polyphenol flavonoid, quercetin-3-O-αL-rhamnopyranoside could be responsible for antioxidant activity of ethno-medicinal property of D filix-mas leaf.

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“…Phenolic compounds including flavonoids form the large group of secondary metabolites, exhibits various structures that make them major contributors to the overall pharmacological potentials like antioxidant and antimicrobial activities of many plants [15][16][17][18]. In this context, it was reasonable to assess the total phenolic (TPC) and flavonoid (TFC) contents of the extracts as well as their antioxidant and antimicrobial activities.…”

Section: Discussionmentioning

confidence: 99%

<i>In vitro</i> antioxidant and antimicrobial activities of aerial parts of Algerian <i>Jurinea humilis</i> DC (Asteraceae)

Ayad¹,

Çakmak²,

Asan-Ozusaglam³

et al. 2018

Trop. J. Pharm Res

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Natural plant polyphenols for alleviating oxidative damage in man: Current status and future perspectives

Abstract: The balance between oxidation and reduction is important for maintaining a healthy biological system. Oxidative stress results from an imbalance between excessive formation of reactive oxygen species (ROS)

Cited by 28 publications

References 74 publications

In Vivo and In Vitro Effects of Tracheloside on Colorectal Cancer Cell Proliferation and Metastasis

In Vivo and In Vitro Effects of Tracheloside on Colorectal Cancer Cell Proliferation and Metastasis

Antioxidant Activities of the Leaf Extract and Fractions of Dryopteris filix-mas (L.) Schott could be Attributed to The Abundance of Polyphenol Compounds

<i>In vitro</i> antioxidant and antimicrobial activities of aerial parts of Algerian <i>Jurinea humilis</i> DC (Asteraceae)

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