&lt;i&gt;In vitro&lt;/i&gt; antioxidant and antimicrobial activities of aerial parts of Algerian &lt;i&gt;Jurinea humilis&lt;/i&gt; DC (Asteraceae)

Ayad, Radia; Çakmak, Yavuz Selim; Asan-Ozusaglam, Meltem; Medjroubi, Kamel; Akkal, Salah

doi:10.4314/tjpr.v16i12.14

Cited by 8 publications

(13 citation statements)

References 12 publications

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“…Furthermore, flavonoids possess biomolecular activities such as apoptosis rate increase, cell proliferation inhibition, lipid peroxidation inhibition, angiogenesis inhibition, DNA oxidation inhibition (Chahar et al, 2011, Yalcın et al, 2017. Most of the Jurinea species are rich in flavonoids such as sesquiterpene lactones and triterpenes (Shah et al, 2014, Singh et al, 2016, Ayad et al, 2017. In phytochemical studies, Jurinea species have been found to contain flavonoids such as apigenin, catechin, caffeic acid and routine (Shah et al, 2014, Ayad et al, 2017, That known for their anticancer activities in various cancer cell lines (Yin et al, 1999, Wenzel et al, 2000, Chahar et al, 2011.…”

Section: Discussionmentioning

confidence: 99%

“…Jurinea dolomiaea Roots were shown to have an antioxidant activity when evaluated by TPC and total flavonoid contents diverse antioxidant assays . In a study evaluated Jurinea humilis for the antimicrobial and antioxidant activities, it was indicated that J. humilis has a good antioxidant (DPPH assay IC50 was 0.16 mg mL -1 ; TPC, 169.14 GAE mg g -1 ) and antimicrobial properties because of the high amount of phenolic and flavonoid contents (Ayad et al 2017). Similarly, Jurinea dolomiaea found to have antibacterial activity (Dwivedi & Wagay 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Most of the Jurinea species are rich in flavonoids such as sesquiterpene lactones and triterpenes (Shah et al, 2014, Singh et al, 2016, Ayad et al, 2017. In phytochemical studies, Jurinea species have been found to contain flavonoids such as apigenin, catechin, caffeic acid and routine (Shah et al, 2014, Ayad et al, 2017, That known for their anticancer activities in various cancer cell lines (Yin et al, 1999, Wenzel et al, 2000, Chahar et al, 2011. Taherkhania and Rustaiyan (2016) show that shirazolide extracted from Jurinea leptoloba show cytotoxicity in HeLA cells (IC50 value was 2.8 μg mL -1 ).…”

Section: Discussionmentioning

confidence: 99%

“…J. brevicaulis grows in and around the Anatolian Dialogue, one of the major centers of endemism and considered as the hot spot of biodiversity in Turkey, and widely distributes in Erzincan and Gümüshane provinces ( Figure 1) (Tubives;Dogan et al, 2007;Gemici et al, 2008). Previous studies show that Jurinea species have been used traditionally as aphrodisiac and in the treatment of eye infections, fever, gout and rheumatism (Singh et al, 2016); And have different biological activities as antioxidant and anti-lipid peroxidation (Shah et al, 2014;Taherkhani 2015, Ayad et al, 2017, antibacterial (Dwivedi and Wagay, 2014;Ayad et al, 2017), antifungal and DNA Protection Activity (Singh et al, 2016) and in vitro cytotoxic potential against cancerous cell lines (Taherkhani and Rustaiyan 2016). However, there is no studies evaluate the biological activity of Turkey endemic J. brevicaulis; Therefore, as a preliminary study of antineoplastic activity, the cytotoxicity and the antioxidant activity were evaluated for methanol, water, chloroform and ethyl acetate J. brevicaulis extracts.…”

Section: Jurinea Brevicaulis Is a Plant Belonging To Thementioning

confidence: 99%

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Jurinea brevicaulis'in Biyolojik Aktivitesi; Sitotoksisite ve Antioksidan Aktivitesi

Asadi

Kanbolat

Batur

et al. 2021

Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi

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Jurinea brevicaulis is a perennial herbaceous plant belonging to the Asteraceae family. J. brevicaulis is an endemic genus and grows Erzincan and Gümüşhane provinces in Turkey. Jurinea species are known to have anticancer, antibacterial, antifungal and antioxidant effects. In this article, it is aimed to evaluate the antioxidant capacity and cytotoxic effects of J. brevicaulis. Results indicate that, TPC values were between 41.7-537.5 GAE µg g-1 , FRAP values were between 109.52-1076.2 µM Trolox equivalent g-1 , CUPRAC values were between 231.4-3083.3 µM Trolox equivalent g-1 , IC50 values in DPPH determination were between 0.0102-3.4174 mg mL-1. The extracts caused cell death in a concentration-dependent manner in, IC50 values were calculated to be between 3.67-10.2 µg mL-1. In conclusion, the cytotoxic effects in cancerous cells and the high antioxidant capacity indicates that J. brevicaulis could be an important herb in developing new drugs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Jurinea Brevicaulis Is a Plant Belonging To Thementioning

confidence: 99%

See 2 more Smart Citations

Jurinea brevicaulis'in Biyolojik Aktivitesi; Sitotoksisite ve Antioksidan Aktivitesi

Asadi

Kanbolat

Batur

et al. 2021

Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi

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“…Experiments using the disc diffusion assay with the methanolic, acetone, and aqueous extracts of 13 lichen species demonstrated that only the methanolic and acetone extracts of oak moss (Evernia prunastri), cartilage lichens (Ramalina farinacea and Ramalina fraxinea) and beard lichen (Usnea florida), and acetone extract of lung lichen (Lobaria pulmonaria) demonstrated moderate activity against L. garvieae [94]. The dichloromethane, methanolic and ethyl acetate extracts of the aerial parts of Aster (Jurinea humilis) showed weak activity in vitro against L. garvieae A4 strain [95]. The ethanolic extracts of Persian violet (Cyclamen pseudibericum), hardy cyclamen (C. hederifolium), and Cilician cyclamen (C. cilicium) also show no significant activity by disk diffusion assay against L. garvieae recovered from diseased rainbow trout [96].…”

Section: In Vitro Studiesmentioning

confidence: 99%

Lactococcosis a Re-Emerging Disease in Aquaculture: Disease Significant and Phytotherapy

Soltani

Baldisserotto

Shekarabi

et al. 2021

Veterinary Sciences

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Lactococcosis, particularly that caused by Lactococcus garvieae, is a major re-emerging bacterial disease seriously affecting the sustainability of aquaculture industry. Medicinal herbs and plants do not have very much in vitro antagonism and in vivo disease resistance towards lactococcosis agents in aquaculture. Most in vitro studies with herbal extractives were performed against L. garvieae with no strong antibacterial activity, but essential oils, especially those that contain thymol or carvacrol, are more effective. The differences exhibited by the bacteriostatic and bactericidal functions for a specific extractive in different studies could be due to different bacterial strains or parts of chemotypes of the same plant. Despite essential oils being shown to have the best anti-L. garvieae activity in in vitro assays, the in vivo bioassays required further study. The extracts tested under in vivo conditions presented moderate efficacy, causing a decrease in mortality in infected animals, probably because they improved immune parameters before challenging tests. This review addressed the efficacy of medicinal herbs to lactococcosis and discussed the presented gaps.

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Isolation, Characterization and in Silico Studies of Secondary Metabolites from Jurinea macrocephala DC. with Antiproliferative Activity

Gürbüz

Doğan

Gündüz

et al. 2022

Chemistry & Biodiversity

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In the present work, cytotoxic potential of Jurinea macrocephala DC. (Asteraceae) was evaluated on A549 lung cancer and MCF‐7 breast cancer cell lines. Isolation studies were carried out using various and repetitive chromatographic methods in order to determine the phytochemical profile of the extracts. These studies led to the identification of twelve compounds; four triterpenes (1–4) and eight flavonoids (5–12). Spectroscopic examination (1D and 2D NMR, ESI‐MS) and comparison with relevant literature data were used to deduce the structures of all isolated molecules. To rationalize the obtained cytotoxicity data against breast cancer cell lines, the isolated compounds were docked into the binding site of aromatase, an important target enzyme for the treatment of breast cancer. Molecular docking studies revealed that flavonoids without sugar moieties (5–8) showed the best binding affinities. Overall, these mentioned compounds turned out to be also the most appropriate oral drug candidates after the calculation of their Lipinski parameters.

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<i>In vitro</i> antioxidant and antimicrobial activities of aerial parts of Algerian <i>Jurinea humilis</i> DC (Asteraceae)

Cited by 8 publications

References 12 publications

Jurinea brevicaulis'in Biyolojik Aktivitesi; Sitotoksisite ve Antioksidan Aktivitesi

Jurinea brevicaulis'in Biyolojik Aktivitesi; Sitotoksisite ve Antioksidan Aktivitesi

Lactococcosis a Re-Emerging Disease in Aquaculture: Disease Significant and Phytotherapy

Isolation, Characterization and in Silico Studies of Secondary Metabolites from Jurinea macrocephala DC. with Antiproliferative Activity

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