Natural organic and inorganic–hydroxyapatite biopolymer composite for biomedical applications

Sathiyavimal, Selvam; Vasantharaj, Seerangaraj; LewisOscar, Felix; Selvaraj, Raja; Brindhadevi, Kathirvel; Pugazhendhi, Arivalagan

doi:10.1016/j.porgcoat.2020.105858

Cited by 69 publications

(30 citation statements)

References 135 publications

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“…Silk fibroin, collagen and chitosan materials in various compositions and weight ratios could be used in bone tissue engineering to fill small bone defects resulting from diseases, traumas, injuries, infections and genetic defects ( Figure 1 ) [ 32 , 33 ]. Treatment of bone defects are a big challenge for modern medicine.…”

Section: Introductionmentioning

confidence: 99%

Biomaterials with Potential Use in Bone Tissue Regeneration—Collagen/Chitosan/Silk Fibroin Scaffolds Cross-Linked by EDC/NHS

et al. 2021

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Blending of different biopolymers, e.g., collagen, chitosan, silk fibroin and cross-linking modifications of these mixtures can lead to new materials with improved physico-chemical properties, compared to single-component scaffolds. Three-dimensional scaffolds based on three-component mixtures of silk fibroin, collagen and chitosan, chemically cross-linked, were prepared and their physico-chemical and biological properties were evaluated. A mixture of EDC (N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride) and NHS (N-hydroxysuccinimide) was used as a cross-linking agent. FTIR was used to observe the position of the peaks characteristic for collagen, chitosan and silk fibroin. The following properties depending on the scaffold structure were studied: swelling behavior, liquid uptake, moisture content, porosity, density, and mechanical parameters. Scanning Electron Microscopy imaging was performed. Additionally, the biological properties of these materials were assessed, by metabolic activity assay. The results showed that the three-component mixtures, cross-linked by EDC/NHS and prepared by lyophilization method, presented porous structures. They were characterized by a high swelling degree. The composition of scaffolds has an influence on mechanical properties. All of the studied materials were cytocompatible with MG-63 osteoblast-like cells.

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Section: Introductionmentioning

confidence: 99%

Biomaterials with Potential Use in Bone Tissue Regeneration—Collagen/Chitosan/Silk Fibroin Scaffolds Cross-Linked by EDC/NHS

et al. 2021

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“…[9][10][11][12] Natural bone exhibits a hierarchical structure consisting of collagen brils, and hydroxyapatite nanocrystallites (nHAp), which are the organic and inorganic components, respectively. 13 For the past years, the development of articial scaffolds that mimic the native bone in terms of the complex structure has attracted scientists in the eld of BTE. Various kinds of synthetic and natural polymers have been combined with nHAp as biomimetic scaffolds for BTE applications.…”

Section: Introductionmentioning

confidence: 99%

“…Various kinds of synthetic and natural polymers have been combined with nHAp as biomimetic scaffolds for BTE applications. [13][14][15][16] Chitosan (CS) is a natural linear polysaccharide that is composed of Dglucosamine and N-acetyl glucosamine units linked through b-(1-4) glycosidic bonds; it is derived from deacetylation of chitin found in the shells of marine crustaceans. 17,18 The structural similarity of CS to glycosaminoglycans, which are the major component of the extracellular matrix (ECM) of bone, plays an important role in cell-cell adhesion by interacting with collagen bers, thereby making CS one of the most attractive natural polymers used for BTE.…”

Section: Introductionmentioning

confidence: 99%

Enhanced biomineralization and protein adsorption capacity of 3D chitosan/hydroxyapatite biomimetic scaffolds applied for bone-tissue engineering

et al. 2020

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“…The precursor of synthesized hydroxyapatite can be derived from chemical or natural resources [ 27 ]. Although the pure form of the precursors can usually increase purity, hydroxyapatites derived from natural resources are more economic and show better metabolic activity and enhanced bioactivity in comparison to their synthetic counterparts [ 3 ]. Suitable natural resources include eggshells [ 28 ], bovine bones [ 29 ], fish scales [ 30 ], etc.…”

Section: Inorganic Particles Used In Dentistrymentioning

confidence: 99%

“…Biopolymer gels are widely used in biomedical applications [ 1 , 2 , 3 ]. Examples include tissue engineering [ 4 , 5 ], wound dressing [ 6 , 7 ], dentistry [ 8 ] and in particular, the combination of biopolymers with nanoparticles to fabricate membranes for periodontal regeneration [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Biopolymers Hybrid Particles Used in Dentistry

Chen

Lee

Huang

2021

Gels

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This literature review provides an overview of the fabrication and application of biopolymer hybrid particles in dentistry. A total of 95 articles have been included in this review. In the review paper, the common inorganic particles and biopolymers used in dentistry are discussed in general, and detailed examples of inorganic particles (i.e., hydroxyapatite, calcium phosphate, and bioactive glass) and biopolymers such as collagen, gelatin, and chitosan have been drawn from the scientific literature and practical work. Among the included studies, calcium phosphate including hydroxyapatite is the most widely applied for inorganic particles used in dentistry, but bioactive glass is more applicable and multifunctional than hydroxyapatite and is currently used in clinical practice. Today, biopolymer hybrid particles are receiving more attention as novel materials for several applications in dentistry, such as drug delivery systems, bone repair, and periodontal regeneration surgery. The literature published on the biopolymer gel-assisted synthesis of inorganic particles for dentistry is somewhat limited, and therefore, this article focuses on reviewing and discussing the biopolymer hybrid particles used in dentistry.

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Natural organic and inorganic–hydroxyapatite biopolymer composite for biomedical applications

Cited by 69 publications

References 135 publications

Biomaterials with Potential Use in Bone Tissue Regeneration—Collagen/Chitosan/Silk Fibroin Scaffolds Cross-Linked by EDC/NHS

Biomaterials with Potential Use in Bone Tissue Regeneration—Collagen/Chitosan/Silk Fibroin Scaffolds Cross-Linked by EDC/NHS

Enhanced biomineralization and protein adsorption capacity of 3D chitosan/hydroxyapatite biomimetic scaffolds applied for bone-tissue engineering

Biopolymers Hybrid Particles Used in Dentistry

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