Natural mussel protein-derived antitumor nanomedicine with tumor-targeted bioadhesion and penetration

He, Yunhong; Wang, Jianwei; Wang, Shuping; Yu, Kaxi; Zhou, Jun; Wang, Jinqiang; Tang, Guping; Gu, Zhen; Bai, Hongzhen

doi:10.1016/j.nantod.2022.101700

Cited by 7 publications

(6 citation statements)

References 46 publications

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“…Lin et al 441 constructed a hypoxia-activated phototrigger TAP to potentiate cancer chemotherapy while leaving normal cells not affected, which was echoed by another research that only elicited PDT in hypoxic solid tumors (up to about 5% O 2 ). In addition, owing to moderate hypoxia (1% O 2 ) insufficient to trigger rapid and effective responsiveness in some cases, deteriorating the hypoxia within tumors by PDT, [442][443][444][445][446][447][448] SDT, 449,450 thrombosisinducing agents, 451 vascular disrupting agents. 452 Given that merely PDT or chemotherapy is hard to inhibit solid tumors which are usually characterized by normoxic and hypoxic regions.…”

Section: Hypoxia-responsive Npsmentioning

confidence: 99%

Advances and applications of nanoparticles in cancer therapy

Huang,

He,

Liang

et al. 2024

MedComm – Oncology

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Rapid growth in nanoparticles (NPs) as delivery systems holds vast promise to promote therapeutic approaches for cancer treatment. Presently, a diverse array of NPs with unique properties have been developed to overcome different challenges and to achieve sophisticated delivery routes for enhancement of a series of therapies. Inspiring advances have been achieved in the field of cancer therapy using NPs. In this review, we aim to summarize the up‐to‐date progression of NPs for addressing various challenges, and expect to elicit novel and potential opportunities alternatively. We first introduce different sorts of NP technologies, illustrate their mechanisms, and present their applications. Then, the achievements made by NPs to break obstacles in delivering cargoes to specific sites through particular routes are highlighted, including long‐circulation, tumor targeting, responsive release, and subcellular localization. We subsequently retrospect recent research of NPs in different cancer treatments from single therapy, like chemotherapy, to combination therapy, like chemoradiotherapy, and to integrative therapy. Finally, the challenges and perspectives of NPs in cancer therapy, and their potential impact on the field of oncology are discussed. We believe this review can offer a deeper understanding of the challenges and opportunities of NPs for cancer therapy.

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Section: Hypoxia-responsive Npsmentioning

confidence: 99%

Advances and applications of nanoparticles in cancer therapy

Huang,

He,

Liang

et al. 2024

MedComm – Oncology

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“…Gu et al also developed a natural mussel adhesion protein (NMP) with tumor-environmentally responsive bioadhesion by binding NMP to a phenyl boric acid-containing prodrug, tirazamine, to construct a phototherapy-chemotherapy composite nano-drug delivery system. 139 It is characterized by the efficient encapsulation of the photosensitizer and pre-chemotherapy drug by the structural characteristics of mussel foot silk protein, and the biological activity of the protein was controlled by the drug molecule as the regulatory unit, which can carry drugs to break through the endogenous and pathological barrier, and carry out targeted residence and penetration at the tumor site. On this basis, the tumor environment-responsive release of drugs, activation of prodrugs, and photodynamic and hypoxia-driven chemotherapy play a synergistic therapeutic role.…”

Section: Drug Deliverymentioning

confidence: 99%

Recent advances in adhesive materials used in the biomedical field: adhesive properties, mechanism, and applications

Liu

2023

J. Mater. Chem. B

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“…This ameliorated the resistance of tumors to photodynamic therapy and hypoxia-driven chemotherapy, demonstrating promising antitumor effects in both in situ (Figure 5B) and metastatic (Figure 5C) breast tumor models. [147] Kuang et al reported a novel mitochondria-localized iridium(III) endoperoxide prodrug 2-O-IrAn prepared into nanoparticles. It effectively overcame the limitation of low oxygen concentration in tumors to PDT under the irradiation of NIR, opening up a new avenue for treating hypoxic tumors.…”

Section: Exploiting Oxygen Deprivation For Tumor Cell Eradicationmentioning

confidence: 99%

“…This ameliorated the resistance of tumors to photodynamic therapy and hypoxia‐driven chemotherapy, demonstrating promising antitumor effects in both in situ (Figure 5B) and metastatic (Figure 5C) breast tumor models. [ 147 ] Kuang et al. reported a novel mitochondria‐localized iridium(III) endoperoxide prodrug 2‐O‐IrAn prepared into nanoparticles.…”

Section: Targeting Cancer Treatment Resistance With Different Mechani...mentioning

confidence: 99%

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Nanodelivery Systems as a Novel Strategy to Overcome Treatment Failure of Cancer

He,

Gou,

Zhang

et al. 2023

Small Methods

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Despite the tremendous progress in cancer treatment in recent decades, cancers often become resistant due to multiple mechanisms, such as intrinsic or acquired multidrug resistance, which leads to unsatisfactory treatment effects or accompanying metastasis and recurrence, ultimately to treatment failure. With a deeper understanding of the molecular mechanisms of tumors, researchers have realized that treatment designs targeting tumor resistance mechanisms would be a promising strategy to break the therapeutic deadlock. Nanodelivery systems have excellent physicochemical properties, including highly efficient tissue‐specific delivery, substantial specific surface area, and controllable surface chemistry, which endow nanodelivery systems with capabilities such as precise targeting, deep penetration, responsive drug release, multidrug codelivery, and multimodal synergy, which are currently widely used in biomedical researches and bring a new dawn for overcoming cancer resistance. Based on the mechanisms of tumor therapeutic resistance, this review summarizes the research progress of nanodelivery systems for overcoming tumor resistance to improve therapeutic efficacy in recent years and offers prospects and challenges of the application of nanodelivery systems for overcoming cancer resistance.

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Natural mussel protein-derived antitumor nanomedicine with tumor-targeted bioadhesion and penetration

Cited by 7 publications

References 46 publications

Advances and applications of nanoparticles in cancer therapy

Advances and applications of nanoparticles in cancer therapy

Recent advances in adhesive materials used in the biomedical field: adhesive properties, mechanism, and applications

Nanodelivery Systems as a Novel Strategy to Overcome Treatment Failure of Cancer

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