Natural Melanogenesis Inhibitors Acting Through the Down-Regulation of Tyrosinase Activity

Chang, Te‐Sheng

doi:10.3390/ma5091661

Cited by 214 publications

(204 citation statements)

References 98 publications

(107 reference statements)

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“…Surprisingly, DNM affected neither the enzyme activity ( Figure 3A) nor the intracellular tyrosinase protein level ( Figure 3B and 3C). Most melanogenesis inhibitors discovered thus far inhibit melanogenesis through down-regulation of intracellular tyrosinase activity [2]. However, our results suggest that DNM exhibited antimelanogenesis activity probably via a different mechanism.…”

Section: Discussioncontrasting

confidence: 52%

“…Although melanin primarily serves a photoprotective function, over-production and accumulation of melanin result in several skin disorders including freckles, melasma, age spots, and other hyper-pigmentation syndromes. Thus several studies on the treatment of skin disorders have focused on inhibiting melanogenesis and preventing abnormal pigmentation [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Methanol Partition Fraction of Ethanol Extract of Discorea nipponica Makino Inhibits Melanogenesis

Ding¹,

Lin²,

Wang³

et al. 2014

Trop. J. Pharm Res

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Section: Discussioncontrasting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Methanol Partition Fraction of Ethanol Extract of Discorea nipponica Makino Inhibits Melanogenesis

Ding¹,

Lin²,

Wang³

et al. 2014

Trop. J. Pharm Res

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“…Pigmentary changes due to the accumulation of melanin are another major characteristic of photoaging. Tyrosinase is a key enzyme that catalyzes melanin biosynthesis in melanocytes (4,6). Previous studies have identified a significant association between the activities of topical treatments, including anti-aging, skin , HUI-YUN WANG 3 , JAI-SING YANG 6 and FU-AN CHEN evening, and anti-wrinkling, and decreased elastase and tyrosinase activity (4,5,7).…”

Section: Introductionmentioning

confidence: 99%

“…Tyrosinase is a key enzyme that catalyzes melanin biosynthesis in melanocytes (4,6). Previous studies have identified a significant association between the activities of topical treatments, including anti-aging, skin , HUI-YUN WANG 3 , JAI-SING YANG 6 and FU-AN CHEN evening, and anti-wrinkling, and decreased elastase and tyrosinase activity (4,5,7). Burdock (Arctium lappa L.), a biennial plant belonging to the Compositae family, has been cultivated in Eastern Asian countries, particularly in Taiwan, China and Japan for use in cooking and in folk medicine as a diuretic, antipyretic and blood purifying agent (8-10).…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of burdock leaves on elastase and tyrosinase activity

Horng

Chiang

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Burdock (Arctium lappa L.) leaves generate a considerable amount of waste following burdock root harvest in Taiwan. To increase the use of burdock leaves, the present study investigated the optimal methods for producing burdock leaf extract (BLE) with high antioxidant polyphenolic content, including drying methods and solvent extraction concentration. In addition, the elastase and tyrosinase inhibitory activity of BLE was examined. Burdock leaves were dried by four methods: Shadow drying, oven drying, sun drying and freeze-drying. The extract solution was then subjected to total polyphenol content analysis and the method that produced BLE with the highest amount of total antioxidant components was taken forward for further analysis. The 1,1-diphenyl-2-pycrylhydrazyl scavenging, antielastase and antityrosinase activity of the BLE were measured to enable the evaluation of the antioxidant and skin aging-associated enzyme inhibitory activities of BLE. The results indicated that the total polyphenolic content following extraction with ethanol (EtOH) was highest using the freeze-drying method, followed by the oven drying, shadow drying and sun drying methods. BLE yielded a higher polyphenol content and stronger antioxidant activity as the ratio of the aqueous content of the extraction solvent used increased. BLE possesses marked tyrosinase and elastase inhibitory activities, with its antielastase activity notably stronger compared with its antityrosinase activity. These results indicate that the concentration of the extraction solvent was associated with the antioxidant and skin aging-associated enzyme inhibitory activity of BLE. The reactive oxygen species scavenging theory of skin aging may explain the tyrosinase and elastase inhibitory activity of BLE.In conclusion, the optimal method for obtaining BLE with a high antioxidant polyphenolic content was freeze-drying followed by 30-50% EtOH extraction. In addition, the antielastase and antityrosinase activities of the BLE produced may be aid in the development of skincare products with antiwrinkle and skin-evening properties. IntroductionThe skin is the largest organ of the human body and has essential functions, including protecting internal organs and regulating body temperature. Collagen and elastin, which are naturally occurring structural proteins in the dermis of the skin, maintain the plumpness, flexibility and elasticity of the skin. Skin aging presents as wrinkling, roughness, dryness, decreased elasticity and uneven pigmentation (1,2). In addition to intrinsic aging, extrinsic aging caused by exposure of the skin to solar radiation is an important concern. Reactive oxygen species (ROS) caused by ultraviolet (UV) radiation are clinically associated with specific markers of photoaging, including wrinkling, and increased elastin and collagen damage (2,3). Elastase digests elastin (4,5). Pigmentary changes due to the accumulation of melanin are another major characteristic of photoaging. Tyrosinase is a key enzyme that catalyzes melanin biosynthesis in...

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“…There are three known mechanisms for the down-regulation of the tyrosinase activity 18 . The most common mechanism reported is the direct inhibition of tyrosinase catalytic activity through tyrosinase inhibitors.…”

Section: Resultsmentioning

confidence: 99%

Phenotype-based screening of selected mangrove methanolic crude extracts with anti-melanogenic activity using zebrafish (Danio rerio) as a model

Grisola¹,

Fuentes²

2017

ScienceAsia

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Novel skin hypopigmenting agents are important due to the unwanted side effects of existing therapies and treatments. In this study, the melanogenic effects of crude extracts of selected mangroves, namely, Avicennia marina, Excoecaria agallocha, Rhizophora apiculata, and Sonneratia alba were screened using zebrafish as a model organism. During the screening process, 50 µg/ml and 100 µg/ml concentrations of the extracts were applied to the zebrafish embryos at 9 h post fertilization and effects were observed at 55 h post fertilization. Among the extracts, S. alba bark extract displayed the best results in terms of its effect on melanogenesis and toxicity. It was further investigated and was found to have a dose-dependent effect on the pigmentation of embryos. Higher dosages of S. alba bark extract such as 400 µg/ml and 500 µg/ml caused profound effects on embryo melanogenesis. IMAGEJ analysis revealed that higher dosages remarkably decreased the ocular melanin content of the embryos. Results suggest that S. alba is a potent source of compounds with anti-melanogenic properties.

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Natural Melanogenesis Inhibitors Acting Through the Down-Regulation of Tyrosinase Activity

Cited by 214 publications

References 98 publications

Methanol Partition Fraction of Ethanol Extract of Discorea nipponica Makino Inhibits Melanogenesis

Methanol Partition Fraction of Ethanol Extract of Discorea nipponica Makino Inhibits Melanogenesis

Inhibitory effect of burdock leaves on elastase and tyrosinase activity

Phenotype-based screening of selected mangrove methanolic crude extracts with anti-melanogenic activity using zebrafish (Danio rerio) as a model

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