AI's integration and adoption in the sector have evolved to be a game-changer through operational revolutionisation regarding accessibility to advanced diagnosis and treatments, reduced waiting times, and cost savings. This chapter explores the strategic efficacy of AI in the context of medical tourism. Using the term “strategic efficacy,” the authors encompass the concept of efficiency and effectiveness of AI in achieving a strategic outcome in medical tourism. The authors' purviews are that is important to ensure that an AI strategy in medical tourism not only looks good on paper but also continues to produce high success for the global practice. In this chapter, the authors discuss AI's emergence in the medical tourism industry, the strategic efficacy of AI in medical tourism, the categories of AI-system devices used in medical tourism, and the AI-system devices. Also discussed are AI systems applications to some major diseases in medical tourism.