Natural Killer Cells in the Late Decades of Human Life

Ogata, Kíyoyuki; Yokose, Norio; Tamura, Hideto; An, Emi; Nakamura, Kyoko; Dan, Kazuo; Nomura, Takeo

doi:10.1006/clin.1997.4401

Cited by 126 publications

(87 citation statements)

References 24 publications

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“…In particular, numerous studies have reported increased numbers of NK cells (irrespective of the surface marker used to characterise them) with advancing age (for reviews, see Lesourd & Mazari, 1999;Mocchegiani & Malavolta, 2004). Preservation of NK cell cytotoxicity and numbers in middle age may be crucial in preventing the development of some age-related diseases and achieving successful ageing; it has been demonstrated that NK cell function is the only parameter in the healthy elderly to be negatively correlated with a severe history of infection or subsequent death owing to infection (Ogata et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Zinc status and age-related changes in peripheral blood leukocyte subpopulations in healthy men and women aged 55–70 y: the ZENITH study

et al. 2005

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Section: Discussionmentioning

confidence: 99%

Zinc status and age-related changes in peripheral blood leukocyte subpopulations in healthy men and women aged 55–70 y: the ZENITH study

et al. 2005

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“…Other aspects of NK cell function, such as the secretion of chemokines or interferon-␥ (IFN-␥) in response to IL-2 are also decreased in the aged (66). NK cells have an important role in immuno-surveillance, and any alterations in their function will influence susceptibility to pathogens and the control of cancer development (77).…”

Section: Nk Cellsmentioning

confidence: 99%

Aging of the Immune System as a Prognostic Factor for Human Longevity

et al. 2008

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“…Other studies in unselected elderly populations showed decreased NK cell functions with aging which was associated with higher incidence of infectious diseases [86,87]. The IL-2 induced NK cell proliferation is decreased with aging [81].…”

Section: Nk Cell Functional Changes With Agingmentioning

confidence: 95%

The Innate Immune System and Aging: What is the Contribution to Immunosenescence ?

Fülöp

Fortin²,

Lesur³

et al. 2012

TOLSJ

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Abstract:The immune system plays an important role in the defence against various threats to health, such as pathogens, cancer cells or modified-self proteins. With aging there is a decrease in the immune response, called immunosenescence, concomitantly with the increase in some age-related diseases such as infections, autoimmune disorders, chronic inflammatory diseases and cancer. The immune response is traditionally divided between innate and adaptive immune responses. Accumulating evidence suggests that immunosenescence is not only restricted to the adaptive but also affects the innate immune system. Assessment of innate immune system functions revealed that it is also susceptible to age-related dysregulation. Furthermore, it is becoming clear that the sustained function of innate cells is indispensable for the adequate functioning of the adaptive immune response. This review will describe the changes in the innate immune response with aging and the recent discoveries, which may shed new light on its contribution to immunosenescence.

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Natural Killer Cells in the Late Decades of Human Life

Cited by 126 publications

References 24 publications

Zinc status and age-related changes in peripheral blood leukocyte subpopulations in healthy men and women aged 55–70 y: the ZENITH study

Zinc status and age-related changes in peripheral blood leukocyte subpopulations in healthy men and women aged 55–70 y: the ZENITH study

Aging of the Immune System as a Prognostic Factor for Human Longevity

The Innate Immune System and Aging: What is the Contribution to Immunosenescence ?

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