Natural killer cells in recurrent miscarriage: An overview

Guerrero, Beatriz Delgado; Hassouneh, Fakhri; Delgado, Elena; Casado, Javier G.; Tarazona, Raquel

doi:10.1016/j.jri.2020.103209

Cited by 46 publications

(39 citation statements)

References 98 publications

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“…Owing to the important role of decidual NK cells in normal pregnancy 24 , 26 , 38 , the PPI analysis between predicted sensory proteins (ESR and PGR) of PPD and cytotoxicity-related molecules (e.g., FCGR3A, NCR3) expressed by NK cells and the network was shown in Figure 7 A. The results showed that ESR and PGR might be important intermediate regulators for NK cell (Fig.…”

Section: Resultsmentioning

confidence: 99%

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Protopanaxadiol improves endometriosis associated infertility and miscarriage in sex hormones receptors-dependent and independent manners

et al. 2021

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Background: Patients with endometriosis (EMs) have high risks of infertility and spontaneous abortion. How to remodel the fertility of patients with EMs has always been the hot spot and difficulty in the field of reproductive medicine. As an aglycone of ginsenosides, protopanaxadiol (PPD) possesses pleiotropic biological functions and has high medicinal values. We aimed to investigate the effect and potential mechanism of PPD in the treatment of EMs-associated infertility and spontaneous abortion. Methods: The EMs mice models were constructed by allotransplantation. The pregnancy rates, embryo implantation numbers and embryo resorption rates of control and EMs were counted. RNA sequencing, qRT-PCR, enzyme linked immunosorbent assay (ELISA) and FCM analysis were performed to screen and confirm the expression of endometrial receptivity/decidualization-related molecules, inflammation cytokines and NK cell function-related molecules in vitro and/or in vivo . The SWISS Target Prediction, STRING and Cytoscape were carried out to predict the potential cellular sensory proteins, the protein-protein interaction (PPI) network between sensory proteins and fertility-related molecules, respectively. Micro-CT detection, liver and kidney function tests were used to evaluate the safety. Results: Here, we observe that PPD significantly up-regulates endometrial receptivity-related molecules (e.g., Lif, Igfbp1, Mmps, collagens ) and restricts pelvic inflammatory response (low levels of IL-12 and IFN-γ) of macrophage, and further remodel and improve the fertility of EMs mice. Additionally, PPD increases the expression of decidualization-related genes and Collagens , and promotes the proliferation, residence, immune tolerance and anagogic functions of decidual NK cells (low levels of CD16 and NKp30, high levels of Ki67, VEGF, TGF-β) in pregnant EMs mice, and further triggers decidualization, decidual NK cell-mediated maternal-fetal immune tolerance and angiogenesis, preventing pregnant EMs mice from miscarriage. Mechanically, these effects should be dependent on ESRs, PGR and other sensory proteins (e.g., AR). Compared with GnRHa (the clinic first-line drug for EMs), PPD does not lead to the decline of serum estrogen and bone loss. Conclusion: These data suggest that PPD prevents EMs-associated infertility and miscarriage in sex hormones receptors-dependent and independent manners possibly, and provides a potential therapeutic strategy with high efficiency and low side effects to remodels the fertility of patients with EMs.

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Section: Resultsmentioning

confidence: 99%

“…Currently, researches on the role of dNK cells in endometrium of EMs patients are still scarce. However, more and more studies have shown the decreased number and activated cytotoxicity of dNK are closed related to spontaneous abortion 24 - 26 .…”

Section: Introductionmentioning

confidence: 99%

Protopanaxadiol improves endometriosis associated infertility and miscarriage in sex hormones receptors-dependent and independent manners

et al. 2021

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“…The placenta has a multifaceted role in the normal development of humans and mammals in general, playing essential functions during pregnancy [22,23]. Its importance is evident when placental development is impaired, leading pathological conditions such as Preeclampsia (PE) [24][25][26][27], Fetal Growth Restriction (FGR) [28][29][30], PreTerm Birth (PTB) [31][32][33], Gestational Diabetes Mellitus (GDM) [34,35], pregnancy loss [36][37][38] and more serious pathologies such as e.g., choriocarcinoma [39]. In addition, normal placental development could be impaired by exposure to toxic agents, virus and bacteria [40][41][42][43] as in chorioamnionitis.…”

Section: Curcumin Effects On Fertilization and Fetal Developmenmentioning

confidence: 99%

The Multifaced Actions of Curcumin in Pregnancy Outcome

et al. 2021

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Curcumin, also known as diferuloylmethane, is the main polyphenolic substance present in the rhizomes of Curcuma longa L. This plant showed many beneficial effects and has been used since ancient times for both food and pharmaceutical purposes. Due to its pleiotropic functions, curcumin consumption in the human diet has become very common thanks also to the fact that this natural compound is considered quite safe as it does not have serious side effects. Its functions as an anti-inflammatory, anti-oxidant, neuroprotective, immunomodulatory, anti-toxicant, anti-apoptotic, and anti-diabetic compound are already known and widely demonstrated. There are numerous studies concerning its effects on various human pathologies including cancer, diabetes and arthritis while the studies on curcumin during pregnancy have been performed only in animal models. Data concerning the role of curcumin as anti-inflammatory compound suggest a possible use of curcumin in managing pregnancy complications such as Preeclampsia (PE), Gestational Diabetes Mellitus (GDM), Fetal Growth Restriction (FGR), PreTerm Birth (PTB), and exposure to toxic agents and pathogens. The aim of this review is to present data to support the possible use of curcumin in clinical trials on human gestation complications.

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“…Women who suffer from RSA generally have higher active performance in the quantity and viability of pNK cells compared with normal pregnant women [ 20 , 21 ]. This may be related to the high cytotoxic activity of pNK [ 22 ]. Human NK cells are categorized into four types, including NK1, NK2, NK3, and NKrl subsets, based on cytokine production [ 23 ].…”

Section: Innate Lymphoid Cellsmentioning

confidence: 99%

The Role of Immune Cells in Recurrent Spontaneous Abortion

Zheng

Zhao

et al. 2021

Reprod. Sci.

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Recurrent spontaneous abortion affects approximately 1–2% of women of childbearing, and describes a condition in which women suffer from three or more continuous spontaneous miscarriages. However, the origin of recurrent spontaneous abortion (RSA) remains unknown, preventing effective treatment and placing stress upon patients. It has been acknowledged that successful pregnancy necessitates balanced immune responses. Therefore, immunological aberrancy may be considered a root cause of poor pregnancy outcomes. Considerable published studies have investigated the relationship between various immune cells and RSA. Here, we review current knowledge on this area, and discuss the five main categories of immune cells involved in RSA; these include innate lymphocytes (ILC), macrophages, decidual dendritic cells (DCs), and T cells. Furthermore, we sought to summarize the impact of the multiple interactions of various immune cells on the emergence of RSA. A good understanding of pregnancy-induced immunological alterations could reveal new therapeutic strategies for favorable pregnancy outcomes.

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Natural killer cells in recurrent miscarriage: An overview

Cited by 46 publications

References 98 publications

Protopanaxadiol improves endometriosis associated infertility and miscarriage in sex hormones receptors-dependent and independent manners

Protopanaxadiol improves endometriosis associated infertility and miscarriage in sex hormones receptors-dependent and independent manners

The Multifaced Actions of Curcumin in Pregnancy Outcome

The Role of Immune Cells in Recurrent Spontaneous Abortion

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