Natural killer cells enhance the immune surveillance of cancer

Nouroz, Faisal; Bibi, Farzana; Noreen, Shumaila; Masood, Nosheen

doi:10.1016/j.ejmhg.2015.08.006

Cited by 14 publications

(13 citation statements)

References 28 publications

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“…In this study, we found that 0.05 μg•kg -1 •h -1 naloxone for patients with sufentanil-controlled analgesia could increase the levels of OGF, NK cells and CD4 + /CD8 + .Studies have shown that OGF can increase NK cells activity and T cells proliferation [8,18,19] . NK cells which could directly kill tumor cells are essential immuno-regulation cellsand they are the primary defensive line in the body [20][21][22] . The decline of NK cell activity can lead to the occurrence and development of tumors [23,24] and the vitality of the NK cell is of great significance in judging clinical prognosis.…”

Section: Discussionmentioning

confidence: 99%

Effect of low dose naloxone on the immune system function of a patient undergoing video-assisted thoracoscopic resection of lung cancer with sufentanil controlled analgesia — a randomized controlled trial

Yun

Miao

Yue

et al. 2019

Preprint

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Background: Perioperative immune function plays an important role in the prognosis of patients. Several studies have indicated that low-dose opioid receptor blockers can improve immune function. Methods: Seventy patients undergoing video-assisted thoracoscopic resection of the lung cancer were randomly assigned to either the naloxone group (n=35) or the non-naloxone group (n=35) for postoperative analgesia during the first 48 hours after the operation. Both groups received sufentanil and palonosetron via postoperative analgesia pump, while 0.05μg·kg -1 ·h -1 naloxone was added in naloxone group. The primary outcomes were the level of opioid growth factor （OGF） and immune function assessed by natural killer cells and CD4 + /CD8 + . Second outcomes were assessed by the score of postoperative pain, postoperative rescue analgesia dose, postoperative nausea and vomiting (PONV). Results: The level of OGF in the naloxone group was significantly increased at 24 hours ( p ＜0.001) and 48 hours after the operation ( P <0.01). The natural killer cells ( P <0.05) and CD4+/CD8+ ( P <0.01) in the naloxone group increased significantly at 48 hours after the operation. The rest VAS score was better with naloxone at 12 and 24 hours after operation（ P <0.05）, and the coughing VAS score was better with naloxone at 48 hours after the operation（ P <0.05). The consumption of postoperative rescue analgesics in the naloxone group was lower (0.00（0.00-0.00）vs 25.00（0.00-62.50））， P <0.05). Postoperative nausea score at 24 hours after operation decreased in naloxone group（0.00 (0.00-0.00) vs 1.00 (0.00-1.00), P < 0.01). Conclusion: Infusion of 0.05μg·kg -1 ·h -1 naloxone for patients undergoing sufentanil-controlled analgesia for postoperative pain can significantly increase the level of OGF, natural killer cells, and CD4 + /CD8+ ，And also reduce the postoperative pain intensity, request for rescue analgesics, and opioid-related side effects. Trial registration: ChiCTR1900021043 on January 26, 2019.

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Section: Discussionmentioning

confidence: 99%

Effect of low dose naloxone on the immune system function of a patient undergoing video-assisted thoracoscopic resection of lung cancer with sufentanil controlled analgesia — a randomized controlled trial

Yun

Miao

Yue

et al. 2019

Preprint

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“…94 NKs can enhance the expression of the domain (CD86) on DCs, which plays an important role in tumor response. 95,96 DCs are a kind of leukocyte derived from bone marrow pluripotent hematopoietic stem cells. Wang et al found that polysaccharide (PSG-1) isolated from G. atrum could stimulate the maturation of DCs in mice.…”

Section: Immunomodulatory Activitymentioning

confidence: 99%

Traditional uses, chemical components and pharmacological activities of the genus Ganoderma P. Karst.: a review

Wang

Zhang

et al. 2020

RSC Adv.

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“…Andrographis paniculata extract is known to be one of the natural products that enhance the efficiency of NK cells in the control of cancer. It promotes NK cell mediated lysis of metastatic tumor cells in mice through an antibody-dependent complement-mediated cytotoxicity [69,70,71]. It also significantly increases the production of interleukin-2 and interferon-gamma and decreases pro-inflammatory cytokines such as TNF-α, GM-CSF, IL-1ß, and IL-6 in tumour-bearing animals [69,70].…”

Section: Binding Site Analysesmentioning

confidence: 99%

The Structure-Based Virtual Screening for Natural Compounds that Bind with the Activating Receptors of Natural Killer Cells

Rowaiye¹,

Oni

Uzochukwu

et al. 2020

Preprint

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Aim: This study is aimed at prospecting for natural compounds that have strong binding affinity for the Activating Receptors of Natural Killer (NK) cells.Background: NK cells are responsible for the immunosurveillance of tumor and virally-infected cells. The cytotoxic potentials of this unique population of immune cells are triggered by the activating receptors. Through ligand-binding, these receptors induce the tyrosine phosphorylation of adapter proteins through their Immunoreceptor Tyrosine-based Activation Motif ITAM sequences and this triggers direct cytotoxicity and the production of cytokines through different signal pathways.Objective: To computationally predict the selectivity, specificity, and efficacy of natural compounds to be used as immunostimulatory agents for cancer treatment. Method:In this study, 1,697 natural compounds were obtained from 82 edible tropical plants through data mining. The molecular docking simulations of these compounds were executed against 18 activating NK cells receptor targets using the Python Prescription 0.8. An arbitrary docking score ≥ -7.0 kcal/mol was chosen as cut off value. Further screening for oral bioavailability, promiscuity, molecular complexity and pharmacokinetic properties using the Swissadme and pkCSM webservers. The ligand similarity analysis and phylogenetic analysis of the receptors was carried out with the ChemMine and Clustal Omega webservers respectively. Binding site analyses and bioactivity prediction were also done with the Protein-Ligand Interaction Profiler and Molinspiration webservers respectively. Normal mode analyses were carried out with the CABS-flex 2.0 server.Result: Seventeen bioactive and non-promiscuous lead compounds with good physicochemical and pharmacokinetic properties were identified. Conclusion:Further tests are required to evaluate the efficacy of the lead compounds.Cancer is a group of diseases characterized by erratic cell growth which invade and spread into other parts of the body [1,2]. They are caused by DNA damage and an ineffective DNA repair mechanism.According to a 2015 WHO report, Cancer is the second leading cause of death globally and there were 90.5 million incidences of cancer in 2015 which accounted for 8.8 million deaths [3].Cancers are caused by a persistent damage to DNA which culminates into mutations of certain gene sequences in the human genome [4]. Expression of these mutant sequences lead to an autonomous and unregulated hyper-proliferation of cells; insufficient apoptosis; altered differentiation and metabolism; genomic instability and immortalization [5]. The abnormal proliferation of cells is due to alterations in the cell cycle replication mechanism due to nuclear and cytoplasm distortions. These changes include hyperchromatism, increased telomerase expression, prominent nucleoli, irregular chromatin distribution within nuclei, and increased size of nucleus, pleomorphism, and chromosomal translocations [6,7].Available cancer therapies such as chemotherapy are non-selective as other normal rapidly divid...

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Natural killer cells enhance the immune surveillance of cancer

Cited by 14 publications

References 28 publications

Effect of low dose naloxone on the immune system function of a patient undergoing video-assisted thoracoscopic resection of lung cancer with sufentanil controlled analgesia — a randomized controlled trial

Effect of low dose naloxone on the immune system function of a patient undergoing video-assisted thoracoscopic resection of lung cancer with sufentanil controlled analgesia — a randomized controlled trial

Traditional uses, chemical components and pharmacological activities of the genus Ganoderma P. Karst.: a review

The Structure-Based Virtual Screening for Natural Compounds that Bind with the Activating Receptors of Natural Killer Cells

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