Natural-killer cells and dendritic cells: “l'union fait la force”

Identification and hormonal regulation of a novel form of NKp30 in human endometrial epithelium

“…Ablation of NKp30 using mAb has been shown to inhibit NK cells' ability to kill tumor cells [7]. NKp30 has also been shown to be important for dendritic cell (DC) maturation [18,19]. Recently, it has been proposed that the appropriate control of the co-stimulation of DC in the peripheral tissues may also induce immune tolerance [20,21].…”

The ‘kiss of death’ by dendritic cells to cancer cells

“…3 The activation of NK and T cells (both CD4 and CD8) are highly dependent on the immunostimulatory properties of the APCs, including DCs. 6,30 DCs are heterogeneous and each subset is characterized by specific anatomical locations as well as functional properties. 31 To fully understand the mechanism of tumor-specific CTL priming, it is important to identify the subset that is responsible for TAA cross-presentation.…”

“…In vitro, IL-12, IL-18, IL-15, and type-I IFN produced by activated cDCs and pDC activate NK proliferation, cytotoxic activity, and IFN-g production. 30 Recent clinical investigations showed that the treatment of patients with Imatinib mesylate (IM/Gleevec s /STI571), an inhibitor of c-kit tyrosine kinase, or with Flt3-L, which induces DC expansion and the DC-mediated NK antitumor effect, is associated with prolonged survival. 48,49 The NK/DC cross talk is bidirectional; NK cells reciprocally trigger and/or sustain maturation of DCs, therefore promoting a T cell-mediated antitumor immune response.…”

“…48,49 The NK/DC cross talk is bidirectional; NK cells reciprocally trigger and/or sustain maturation of DCs, therefore promoting a T cell-mediated antitumor immune response. The NK-mediated maturation of DCs is based on cell-to-cell contact, especially involving NKp30 and proinflammatory cytokines including TNF-a/ IFN-g (for a complete review see Walzer et al 30 ). In addition, NK cells participate in the editing of DCs undergoing maturation by promoting apoptosis of immature DCs.…”

Ikdc

“…L'ensemble des DC expriment les antigènes CMH de classe II, mais n'expriment pas NK1.1. NK et DC coopèrent [6] : l'IFNγ sécrété par les NK stimule les DC, qui, à leur tour, contribuent à l'activation des NK, notamment via les IL-12 et -15. Cette dernière cytokine est essentielle au développement des NK [1], mais aussi via les IFN de type I. Une des difficultés de cette caractérisation phénotypique vient de ce que la majorité de ces marqueurs sont communs à plusieurs populations lymphoïdes ou myéloïdes : CD11c (une chaîne α des intégrines) qui est exprimée en association avec CD18 (chaîne β2 des intégrines), est portée par les macrophages, les NK et les polynucléaires ; CD11b (une autre chaîne α des intégrines), toujours associée à CD18, est présente à la surface des cDC, des NK, et des cellules granulo-macrophagiques ; B220 (une isoforme de la phosphatase membranaire CD45, CD45R) est exprimée par les pré-curseurs B, les lymphocytes B, et les cellules NK matures, Ly-6C par la majorité des cellules myéloïdes.…”