Natural killer cell membrane infused biomimetic liposomes for targeted tumor therapy

Pitchaimani, Arunkumar; Nguyen, Tuyen Duong Thanh; Aryal, Santosh

doi:10.1016/j.biomaterials.2018.01.018

Cited by 182 publications

(160 citation statements)

References 43 publications

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“…However, the hydrodynamic diameter is the real diameter under hydrated conditions that was larger than those observed by TEM. This phenomenon is commonly found in previous report [51,52].…”

Section: Characterization Of Dg-peg-cys-9r 9r/dg-gns and Tsl-9r/dg-gnssupporting

confidence: 82%

Combined Modality Therapy Based on Hybrid Gold Nanostars Coated with Temperature Sensitive Liposomes to Overcome Paclitaxel-Resistance in Hepatic Carcinoma

Han

Gan

et al. 2019

Pharmaceutics

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In this study, we prepared gold nanostar (GNS) composite nanoparticles containing siRNA of cyclooxygenase-2(siCOX-2) that were modified by tumor targeting ligand 2-deoxyglucose (DG) and transmembrane peptide 9-poly-D-arginine (9R) to form siCOX-2(9R/DG-GNS). Paclitaxel loaded temperature sensitive liposomes (PTX-TSL) were surface-modified to produce PTX-TSL-siCOX-2(9R/DG-GNS) displaying homogeneous star-shaped structures of suitable size (293.93 nm ± 3.21) and zeta potentials (2.47 mV ± 0.22). PTX-TSL-siCOX-2(9R/DG-GNS) had a high thermal conversion efficiency under 808 nm laser radiation and a superior transfection efficiency, which may be related to the targeting effects of DG and increased heat induced membrane permeability. COX-2 expression in HepG2/PTX cells was significantly suppressed by PTX-TSL-siCOX-2(9R/DG-GNS) in high temperatures. The co-delivery system inhibited drug-resistant cell growth rates by ≥77% and increased the cell apoptosis rate about 47% at elevated temperatures. PTX-TSL and siCOX-2 loaded gold nanostar particles, therefore, show promise for overcoming tumor resistance.

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“…However, the hydrodynamic diameter is the real diameter under hydrated conditions that was larger than those observed by TEM. This phenomenon is commonly found in previous report [51,52].…”

Section: Characterization Of Dg-peg-cys-9r 9r/dg-gns and Tsl-9r/dg-gnssupporting

confidence: 82%

Combined Modality Therapy Based on Hybrid Gold Nanostars Coated with Temperature Sensitive Liposomes to Overcome Paclitaxel-Resistance in Hepatic Carcinoma

Han

Gan

et al. 2019

Pharmaceutics

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“…Similarly, Chen and co‐workers found that coating nanoparticles with neutrophil membranes could improve their homing to the metastatic niche and effectively prevent early metastasis and suppress the progression of already‐formed metastases . In addition, a natural killer cell membrane‐camouflaged liposome system has also been developed for targeted tumor therapy …”

Section: Bioinspired Strategies From Metastasis‐associated Materials mentioning

confidence: 99%

Rational Design of Nanoparticles with Deep Tumor Penetration for Effective Treatment of Tumor Metastasis

Zhang

Wang

Tan

et al. 2018

Adv Funct Materials

118

106

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The limited penetration of nanoparticles in primary tumors and metastases remains a great challenge for effective treatment of tumor metastasis. This review outlines the current approaches and summarizes the rational design of nanoparticles with deep tumor penetration capacity for anti-metastasis treatment. There are two ways to achieve better tumor penetration; through rational regulation of the physicochemical properties of nanoparticles and through remodeling of the tumor microenvironment, including the tumor vasculature and stromal environment. Moreover, biomimetic strategies that integrate the advantages of nanoparticles and metastasis-homing molecules during cancer cell metastasis are discussed. These efforts have led to promising results in facilitating intratumoral permeation of various nanoparticles to enhance antitumor effects. The considerations and some feasible future directions for deep tumor penetration strategies are proposed to improve tumor metastasis therapies.

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“…Moreover, the subset of lymphocytes named as natural killer (NK) cells have been recently employed to produce DOX-loaded liposomes coated with membranes derived by active NK [42], thus achieving efficient cancer targeting (Figure 3). The resulting "NKsomes", revealed a higher and improved attraction for cancer cells in vitro and in vivo, with a longer circulation half-life.…”

Section: Leucocyte Cell Membrane-covered Npsmentioning

confidence: 99%

“…Illustration of target cancer therapy using activated natural killer (NK) cells and liposomes coated with NK membrane (NKsomes). Reproduced with permission from Ref [42]…”

mentioning

confidence: 99%

Biomimetic Nanocarriers for Cancer Target Therapy

et al. 2020

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Nanotechnology offers innovative tools for the design of biomimetic nanocarriers for targeted cancer therapy. These nano-systems present several advantages such as cargo’s protection and modulation of its release, inclusion of stimuli-responsive elements, and enhanced tumoral accumulation. All together, these nano-systems suffer low therapeutic efficacy in vivo because organisms can recognize and remove foreign nanomaterials. To overcome this important issue, different modifications on nanoparticle surfaces were exploited in order to reach the desired therapeutic efficacy eliciting, also, the response of immune system against cancer cells. For this reason, more recently, a new strategy involving cell membrane-covered nanoparticles for biomedical application has been attracting increasing attention. Membranes from red blood cells, platelets, leukocytes, tumor, and stem cells, have been exploited as biomimetic coatings of nanoparticles for evading clearance or stimulated immune system by maintaining in the same way their targeting capability. In this review, the use of different cell sources as coating of biomimetic nanocarriers for cancer therapy is discussed.

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Natural killer cell membrane infused biomimetic liposomes for targeted tumor therapy

Cited by 182 publications

References 43 publications

Combined Modality Therapy Based on Hybrid Gold Nanostars Coated with Temperature Sensitive Liposomes to Overcome Paclitaxel-Resistance in Hepatic Carcinoma

Combined Modality Therapy Based on Hybrid Gold Nanostars Coated with Temperature Sensitive Liposomes to Overcome Paclitaxel-Resistance in Hepatic Carcinoma

Rational Design of Nanoparticles with Deep Tumor Penetration for Effective Treatment of Tumor Metastasis

Biomimetic Nanocarriers for Cancer Target Therapy

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