Combined Modality Therapy Based on Hybrid Gold Nanostars Coated with Temperature Sensitive Liposomes to Overcome Paclitaxel-Resistance in Hepatic Carcinoma

Han, Wei; Gan, Ye Hua; Li, Qiaofeng; Li, Xiaolan; Shao, Lanlan; Zhu, Dong; Guo, Hongwei

doi:10.3390/pharmaceutics11120683

Cited by 16 publications

(20 citation statements)

References 69 publications

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“…For example, Guo and co‐workers prepared a gold nanostar (GNS), followed by complexing it with therapeutic siRNA. [ 361 ] Sequentially, the resulting siRNA/GNS complexes were loaded into a Ptx‐containing thermo‐sensitive liposomes. With such a hybridized carrier design, the resulting hybrids showed capabilities of intracellular rapid release of the loading payload, enhanced uptake by tumor cells and overcoming MDR in cancer cells.…”

Section: Therapeutic Modalities For Combating Cancer Via O/i Hybridsmentioning

confidence: 99%

Organic/Inorganic Self‐Assembled Hybrid Nano‐Architectures for Cancer Therapy Applications

Yang

Lin

Chen

et al. 2021

Macromolecular Bioscience

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Since the conceptualization of nanomedicine, numerous nanostructure‐mediated drug formulations have progressed into clinical trials for treating cancer. However, recent clinical trial results indicate such kind of drug formulations has a limited improvement on the antitumor efficacy. This is due to the biological barriers associated with those formulations, for example, circulation stability, extravasation efficiency in tumor, tumor penetration ability, and developed multi‐drug resistance. When employing for nanomedicine formulations, pristine organic‐based and inorganic‐based nanostructures have their own limitations. Accordingly, organic/inorganic (O/I) hybrids have been developed to integrate the merits of both, and to minimize their intrinsic drawbacks. In this context, the recent development in O/I hybrids resulting from a self‐assembly strategy will be introduced. Through such a strategy, organic and inorganic building blocks can be self‐assembled via either chemical covalent bonds or physical interactions. Based on the self‐assemble procedure, the hybridization of four organic building blocks including liposomes, micelles, dendrimers, and polymeric nanocapsules with five functional inorganic nanoparticles comprising gold nanostructures, magnetic nanoparticles, carbon‐based materials, quantum dots, and silica nanoparticles will be highlighted. The recent progress of these O/I hybrids in advanced modalities for combating cancer, such as, therapeutic agent delivery, photothermal therapy, photodynamic therapy, and immunotherapy will be systematically reviewed.

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Section: Therapeutic Modalities For Combating Cancer Via O/i Hybridsmentioning

confidence: 99%

Organic/Inorganic Self‐Assembled Hybrid Nano‐Architectures for Cancer Therapy Applications

Yang

Lin

Chen

et al. 2021

Macromolecular Bioscience

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“…Then, 0.5 mL of the release sample was taken out and replaced with an equal volume of fresh release medium at predetermined intervals. 19 , 33 The content of siRNA in the samples was determined by spectrofluorometer, and the cumulative release of siRNA was calculated according to Equation (2) :

where V is the volume of release medium, C t represents the determined concentration of siRNA in the collected samples at time t, ∑C m denotes the concentration sum of the collected samples, V r corresponds to the volume of samples removed for analysis, and Dose is the amount of siRNA added into the release medium.…”

Section: Methodsmentioning

confidence: 99%

Macrophage membrane- and cRGD-functionalized thermosensitive liposomes combined with CPP to realize precise siRNA delivery into tumor cells

Nai

Zhang

et al. 2022

Molecular Therapy - Nucleic Acids

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Despite the success of small interfering RNAs (siRNAs) in clinical settings, their fast clearance and poor delivery efficiency to target cells still hinder their therapeutic effect. Herein, a new treatment system was constructed by combining thermosensitive liposomes with the macrophage membrane, tumor-targeting cyclic Arg-Gly-Asp peptide, a cell-penetrating peptide, and thermotherapy. The constructed system was found to be thermosensitive and stable; the proteins were inherited from the macrophage membrane. This new system combined with thermotherapy displayed the least uptake by macrophages, the greatest uptake by HepG2 cells, the most obvious HepG2 cell apoptosis, and the strongest inhibition of Bcl-2 mRNA and Bcl-2 protein in HepG2 cells. Moreover, 24 h after system administration in tumor-bearing mice, the most prominent distribution of siRNA was observed in tumors, while almost no siRNA was found in other organs. The strongest inhibition of Bcl-2 mRNA, Bcl-2 protein, and tumors was found in mice that had received the proposed system. In summary, when using the constructed system both in vitro and in mice, less uptake by the reticuloendothelial system, greater accumulation in tumor cells, and improved therapeutic efficacy were observed. Therefore, this new system can deliver siRNA selectively and efficiently, and it is a promising therapeutic candidate for precise tumor-targeted therapy.

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“…The NIR-responsive liposomes were established by incorporating AuNSs with a diameter of 45-50 nm into the aqueous core of liposomes, which allows the conversion of NIR-light energy to heat energy to con-trol the drug release [99]. Another report developed a PTX-TSL-AuNS co-delivery system, which has the advantages of rapid PTX release and easy intracellular uptake under hyperthermia [100]. The encapsulation efficiency and drug loading of PTX are about 92.3% and 7.2%, respectively, suggesting a feasible method for PTX delivery.…”

Section: Preparation Methods and Encapsulation Strategy Of Nirn-lipsmentioning

confidence: 99%

“…The encapsulation efficiency and drug loading of PTX are about 92.3% and 7.2%, respectively, suggesting a feasible method for PTX delivery. This co-delivery system exhibits high stability for minimal changes in size and PDI during three weeks at 4 • C [100]. Studies have found that the binding of AuNPs on liposomes' surface easily generated liposomes aggregation and drug leakage [101].…”

Section: Preparation Methods and Encapsulation Strategy Of Nirn-lipsmentioning

confidence: 99%

Design and Application of Near-Infrared Nanomaterial-Liposome Hybrid Nanocarriers for Cancer Photothermal Therapy

et al. 2021

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Liposomes are attractive carriers for targeted and controlled drug delivery receiving increasing attention in cancer photothermal therapy. However, the field of creating near-infrared nanomaterial-liposome hybrid nanocarriers (NIRN-Lips) is relatively little understood. The hybrid nanocarriers combine the dual superiority of nanomaterials and liposomes, with more stable particles, enhanced photoluminescence, higher tumor permeability, better tumor-targeted drug delivery, stimulus-responsive drug release, and thus exhibiting better anti-tumor efficacy. Herein, this review covers the liposomes supported various types of near-infrared nanomaterials, including gold-based nanomaterials, carbon-based nanomaterials, and semiconductor quantum dots. Specifically, the NIRN-Lips are described in terms of their feature, synthesis, and drug-release mechanism. The design considerations of NIRN-Lips are highlighted. Further, we briefly introduced the photothermal conversion mechanism of NIRNs and the cell death mechanism induced by photothermal therapy. Subsequently, we provided a brief conclusion of NIRNs-Lips applied in cancer photothermal therapy. Finally, we discussed a synopsis of associated challenges and future perspectives for the applications of NIRN-Lips in cancer photothermal therapy.

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Combined Modality Therapy Based on Hybrid Gold Nanostars Coated with Temperature Sensitive Liposomes to Overcome Paclitaxel-Resistance in Hepatic Carcinoma

Cited by 16 publications

References 69 publications

Organic/Inorganic Self‐Assembled Hybrid Nano‐Architectures for Cancer Therapy Applications

Organic/Inorganic Self‐Assembled Hybrid Nano‐Architectures for Cancer Therapy Applications

Macrophage membrane- and cRGD-functionalized thermosensitive liposomes combined with CPP to realize precise siRNA delivery into tumor cells

Design and Application of Near-Infrared Nanomaterial-Liposome Hybrid Nanocarriers for Cancer Photothermal Therapy

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