Natural Killer Cell Activity in Patients with Gynecologic Malignancies: Correlation with Histologic Grading and Stage of Disease

Garzetti, G. G.; Cignitti, M.; Marchegiani, Francesca; Ciavattini, Andrea; Tranquilli, Andrea Luigi; Fabris, Ν.; Romaninï, Carlo

doi:10.1159/000292724

Cited by 7 publications

(4 citation statements)

References 6 publications

(8 reference statements)

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“…The decrease of natural killer activity was more important in presence of myometrial invasion > 50%, suggesting a relationship between basal immune reactivity and neoplastic progression. The results are in agreement with previous studies on gynecologic malignancies, which showed an immune reactivity decrease in advanced stage disease (14,15,17); however, in endometrial carcinoma the impairment of natural cytotoxicity was significant also in stage I disease, when the immune function is usually still preserved. The role of immune surveillance seems to be of primary importance also in the earlier phases of endometrial cancer growth, suggesting that natural killer activity is an effective functional index of immune status.…”

Section: Discussionsupporting

confidence: 92%

The relationshp of clinical‐pathologic status and adiuvant treatment with natural hller cell activity in stage I and II endometrial carcinoma

Garzetti¹,

Ciavattini²,

Muzzioli³

et al. 1994

Acta Obstet Gynecol Scand

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I(.I(I Oh.v/er Gjwecol Scmd 1994: 73: 652-657. (ij Acta Obstet Gynecol Scand 1994Ohjwriw. The aim of our study was to evaluate the basal immune reactivity in patients with locally advanced endometrial carcinoma, and the immune modulating effect of adjuvant treatment in cancer population randomized to endocrine or radiation therapy. M t r /~r . ; d otitl t w k o d s . Forty-three patients with F I G 0 stage I and II endometrial carcinoma, treated with primary radical surgery, were randomly selected to receive endocrine (medroxyprogesterone acetate 30 mg weekly and Tamoxifen 300 mg weekly, given consecutively) or radiation adjuvant treatment (external beam photon treatment of the whole pelvis, with an average total dose of 3680 cGy rad). The immune assay included the evaluation of natural killer cell activity by target cell retention of the fluorescent dye carboxyfluoresceyn diacetate. using sensitive cell line K 562. The immunological monitoring was performed before surgery, and !hen before, during, and after adjuvant treatment. Nine patients, who refused any adjuvant treatment, were recruited as controls. Kc.trl1r.s. Patients, matched for age and demographic characteristics. with locally advanced endometrial carcinoma had significantly lower mean values of natural killer activity than in henlthy controls: the decrease of natural cytotoxicity was significantly related to the depth of inyometrial invasion. The adjuvant treatment was associated with a significant immune modulation: patients in endocrine therapeutic regimen showed an increase of natural killer activity. while patients in radiation therapy had a reduction; in the control group there was no significant modification of natural cytotoxicity during negative follow up. ~'~i / i r , /~~. s i f~t i . s .

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Section: Discussionsupporting

confidence: 92%

The relationshp of clinical‐pathologic status and adiuvant treatment with natural hller cell activity in stage I and II endometrial carcinoma

Garzetti¹,

Ciavattini²,

Muzzioli³

et al. 1994

Acta Obstet Gynecol Scand

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“…There have been studies in patients with cancer which demonstrate a link between overall survival and improved immunomodulators [10–12]. Our data show that the average CD4, CD8 and NK cell levels were higher at almost every course of chemotherapy (Fig.…”

Section: Discussionsupporting

confidence: 54%

“…For example, cytotoxic immune response by T cells (including CD 4 and CD 8 ), as well as NK cells plays a key role in the recognition and destruction of malignant cells, and have been reported to be improved following massage therapy. NK cell cytotoxic activity is decreased in multiple advanced cancers, including gynecologic malignancies [10]. An increase in NK cells was shown to have a beneficial impact on survival in malignant melanoma patients [11].…”

Section: Introductionmentioning

confidence: 99%

A prospective, randomized trial of integrative medicine for women with ovarian cancer

Judson

Dickson

Argenta

et al. 2011

Gynecologic Oncology

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Objectives Despite increased use of integrative medicine in cancer therapy, little data exist on its efficacy. This prospective, randomized, pilot trial sought to evaluate the feasibility of combined modality integrative medicine (CM-IM) in women with ovarian cancer (OvCA) and evaluate its effects on quality of life (QoL), chemotherapy toxicity and immunologic profiles. Methods Women with newly diagnosed OvCA requiring chemotherapy were offered enrollment. Those randomized to the experimental arm received hypnosis, therapeutic massage and healing touch with each cycle of chemotherapy. The control arm received chemotherapy without CM-IM. All patients completed QoL questionnaires prior to cycles 1, 3 and 6, and 6-months after chemotherapy. Immunologic profiles were measured. Statistical analysis was based on intent-to-treat. Student’s t-test and Fischer’s exact-test were used to determine differences. Results Forty-three women enrolled. All women randomized to CM-IM were successfully treated. There were no statistical differences between the groups in age, stage, grade, histologic cell type, CA125 levels, or surgical cytoreductive status. There was no difference in overall QoL measurements. Re-hospitalization rates, treatment delays, anti-emetic use, and infection rates were similar. Immunologic profiles revealed no difference between arms for WBC or salivary IgA levels. Women receiving CM-IM had consistently higher levels of CD4, CD8 and NK cells, although this did not reach statistical significance. Conclusions Prospective clinical evaluation of integrative medicine for women with gynecologic malignancy is feasible. This first, pilot study of CM-IM in gynecologic oncology demonstrated no improvement in QoL or chemotherapy toxicity. Integrative medicine-associated improvements in immunologic profiles warrant further investigation.

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“…The immune system is considered greatly important in the defence against neoplastic development (8)(9)(10)(11)(12)(13), and lymph nodes are fundamental components of the peripheral immune system. Beyond their role as a passive filter, lymph nodes play an active part in immunological defence and perform a barrier function during the spread of malignant neoplasia (14).…”

Section: Submitted 15 Novetiibrr 1994 a C W P T E D 21) Fdwuarj 1995mentioning

confidence: 99%

Nodal immune reactivity in FIGO Stage I endometrial carcinoma: relationship with myometrial invasion

Garzetti¹,

Ciavattini²,

Goteri

et al. 1995

Acta Obstet Gynecol Scand

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Natural Killer Cell Activity in Patients with Gynecologic Malignancies: Correlation with Histologic Grading and Stage of Disease

Cited by 7 publications

References 6 publications

The relationshp of clinical‐pathologic status and adiuvant treatment with natural hller cell activity in stage I and II endometrial carcinoma

The relationshp of clinical‐pathologic status and adiuvant treatment with natural hller cell activity in stage I and II endometrial carcinoma

A prospective, randomized trial of integrative medicine for women with ovarian cancer

Nodal immune reactivity in FIGO Stage I endometrial carcinoma: relationship with myometrial invasion

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