Natural joints: Boundary lubrication and antiphospholipid syndrome (APS)

Pawlak, Zenon; Mreła, Aleksandra; Kaczmarek, Mariusz; Cieszko, M.; Urbaniak, Wiesław

doi:10.1016/j.biosystems.2018.10.018

Cited by 10 publications

(9 citation statements)

References 19 publications

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“…The resulting aβ2GPI is responsible for cartilage degradation of phospholipid bilayers and, therefore, boundary-lubricating ability is deactivated. 28 Moreover, through multiple mechanisms, aPL activity results not only in vasculopathy, thrombosis, and pregnancy complications but also in inflammation. 3 So, could aβ2GPI be both the cause and the consequence of the inflammation in the synovial joints?…”

Section: Discussionmentioning

confidence: 99%

IgA is the predominant isotype of anti‐β2 glycoprotein I antibodies in rheumatoid arthritis

Melayah

Changuel

Mankaï

et al. 2020

Clinical Laboratory Analysis

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Rheumatoid arthritis (RA) is a chronic, inflammatory joint disease of autoimmune nature. The ethiopathogenic mechanisms involved are complex and include gut dysbiosis. 1 RA is characterized by autoantibodies production (rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA)). RA can lead to accumulating joint damage and irreversible disability. 2 Antiphospholipid antibodies (aPL) are a heterogeneous group of antibodies that have been associated with thrombotic or obstetrical events in patients with antiphospholipid syndrome (APS). 3 These antibodies can occur not only in APS but also in a

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Section: Discussionmentioning

confidence: 99%

IgA is the predominant isotype of anti‐β2 glycoprotein I antibodies in rheumatoid arthritis

Melayah

Changuel

Mankaï

et al. 2020

Clinical Laboratory Analysis

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“…Binding β2-GP I to anionic charged phospholipid groups (-PO 4 − ) at a pH of 7.4 causes a change in the protein conformation [46][47][48]. The softening of the cartilage is the first phase of cartilage deterioration [45,49]. Classical morphological changes of articular cartilage of bones and joints start with fibrillation and local disorganization of the surface, which results in the cleavage of cartilage surface layers.…”

Section: Deactivation Of a Surface-active Phospholipid Bilayermentioning

confidence: 99%

“…The continued deterioration of cartilage leads to subchondral bone exposure and more generalized synovial lesions. Understanding cartilage damage is essential for looking at the cellular processes and biochemical structure of healthy cartilage [49].…”

Section: Deactivation Of a Surface-active Phospholipid Bilayermentioning

confidence: 99%

Understanding the Unique Role of Phospholipids in the Lubrication of Natural Joints: An Interfacial Tension Study

et al. 2019

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Some solid lubricants are characterized by a layered structure with weak (van der Waals) inter-interlayer forces which allow for easy, low-strength shearing. Solid lubricants in natural lubrication are characterized by phospholipid bilayers in the articular joints and phospholipid lamellar phases in synovial fluid. The influence of the acid–base properties of the phospholipid bilayer on the wettability and properties of the surface have been explained by studying the interfacial tension of spherical lipid bilayers based on a model membrane. In this paper, we show that the phospholipid multi-bilayer can act as an effective solid lubricant in every aspect, ranging from a ‘corrosion inhibitor’ in the stomach to a load-bearing lubricant in bovine joints. We present evidence of the outstanding performance of phospholipids and argue that this is due to their chemical inertness and hydrophilic–hydrophobic structure, which makes them amphoteric and provides them with the ability to form lamellar structures that can facilitate functional sliding. Moreover, the friction coefficient can significantly change for a given phospholipid bilayer so it leads to a lamellar-repulsive mechanism under highly charged conditions. After this, it is quickly transformed to result in stable low-friction conditions.

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“…At a pH around 7, β2-GPI -amino acids (arginine, lysine and tryptophan) are positively charged (-NH3 + ): an acid-base interaction occurs between the protonated amino acid group (-NH3 + ) and the phosphate (-PO4 -) membrane group: (β2-GPI-NH3 + ) + (PLs-PO4 -) → (-NH3 + PO4 -) interaction and electrostatic attractions is strong enough to destroy the PLs bilayer on the articular surface and deactivate all phospholipids in the synovial fluid (SF). Under the conditions of our experiment, the phospholipids in the solutions can be deactivated by β2-GPI as well [18][19]. It is important to consider the effect of β2-Glycoprotein I in future studies on articular cartilage degeneration.…”

Section: Figure 2 3d Topographical Image Of Articular Cartilage: (A) ...mentioning

confidence: 88%

Atomic force microscope observation of the surfaces of natural articular cartilage

Pawlak¹

2022

JSCRI

Self Cite

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Hydrophilic and negatively charged natural cartilage surface is covered by phospholipids bilayers. These phospholipids have been demonstrated to exert highly desirable characteristics on the surface articular cartilage such as efficient lubrication, load processing, and semipermeability for nutrient transport. We examined a bovine cartilage (BC) surface using atomic force microscope. The study was performed using cartilage samples with healthy surfaces and completely depleted surface phospholipids. The artificially degraded cartilage surfaces (lipid depleted) were resurfaced with different species and combinations of synthetic bilayer of phospholipids found in human joints. Our results demonstrated that it is possible to recreate a potentially viable layer of phospholipids on the surface of degenerated cartilage. However, further studies will be required to advance the resurfacing idea developed in this paper for the potential treatment of osteoarthritis and other related orthopedic joint conditions.

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Natural joints: Boundary lubrication and antiphospholipid syndrome (APS)

Cited by 10 publications

References 19 publications

IgA is the predominant isotype of anti‐β2 glycoprotein I antibodies in rheumatoid arthritis

IgA is the predominant isotype of anti‐β2 glycoprotein I antibodies in rheumatoid arthritis

Understanding the Unique Role of Phospholipids in the Lubrication of Natural Joints: An Interfacial Tension Study

Atomic force microscope observation of the surfaces of natural articular cartilage

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