IgA is the predominant isotype of anti‐β2 glycoprotein I antibodies in rheumatoid arthritis

Abstract

Rheumatoid arthritis (RA) is a chronic, inflammatory joint disease of autoimmune nature. The ethiopathogenic mechanisms involved are complex and include gut dysbiosis. 1 RA is characterized by autoantibodies production (rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA)). RA can lead to accumulating joint damage and irreversible disability. 2 Antiphospholipid antibodies (aPL) are a heterogeneous group of antibodies that have been associated with thrombotic or obstetrical events in patients with antiphospholipid syndrome (APS). 3 These antibodies can occur not only in APS but also in a

Frequency of serological markers of rheumatoid arthritis in patients with IgA anti‐β2 glycoprotein I antibodies

“…However, aβ2GPI‐IgA can be observed in autoimmune diseases other than APS. In fact, we have previously demonstrated a significantly higher frequency of aβ2GPI‐IgA in patients with celiac disease, primary biliary cholangitis, and RA than in a healthy population 7–9 …”

“…In fact, we have previously demonstrated a significantly higher frequency of aβ2GPI-IgA in patients with celiac disease, primary biliary cholangitis, and RA than in a healthy population. [7][8][9] In this study, the frequency of antibodies of RA (CCP-Ab or RF)…”

“…In fact, it has been shown that isolated aβ2GPI‐IgA positivity (without IgG or IgM aCL/aβ2GPI and LA) is associated with venous thrombosis and pregnancy morbidity 4 . However, aβ2GPI‐IgA was demonstrated in autoimmune diseases other than APS 7–9 …”

“…18 Since many similarities exist between APS and RA and we have previously demonstrated that aβ2GPI-IgA is frequent in patients with RA. 9 The objective of the present study was therefore to know if the vice versa is true by determining the serological markers of RA in patients who have aβ2GPI-IgA.…”

Metabolic syndrome in rheumatoid arthritis patients: Relationship among its clinical components

“…This finding could be explained by the effect of tobacco smoking on tissue protein citrullination, and also detonate of autoantibodies synthesis, which show to induce the disease progression and disease activity in patients with rheumatoid arthritis. [42][43][44] On the other hand, the association of DAS-28 and VLDL-C levels is not clear yet, but it has been reported that RA patients with high disease activity had alterations of the lipid profile. 38,45 Rheumatoid factor (RF) correlated with age and smoking index, which agrees with other reports [46][47][48] ; likewise, RF correlated with triglycerides, which could be explained by this autoantibody´s positive correlation with a high RA disease activity, 49 a status associated with lipids alteration.…”