Natural history, pathophysiology and evaluation of gastroesophageal reflux disease

Chatila, Ahmed; Nguyen, Minh Thu T.; Krill, Timothy; Roark, Russell; Bilal, Mohammad; Reep, Gabriel

doi:10.1016/j.disamonth.2019.02.001

Cited by 48 publications

(47 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, GERD is one of the main healthcare issues in North America and Europe, placing a significant economic burden on society. For example, in the US, GERD is a common reason for consultation in primary and secondary care, with estimated costs that exceed 10 billion USD per year [8,9].…”

Section: Epidemiologymentioning

confidence: 99%

See 1 more Smart Citation

Gastroesophageal Reflux Disease and Probiotics: A Systematic Review

Cheng

Ouwehand

2020

Nutrients

View full text Add to dashboard Cite

Probiotic is little known for its benefits on upper gastrointestinal health. The objective of this systematic review was to examine the efficacy of probiotics in alleviating the frequency and severity of symptoms in gastroesophageal reflux disease (GERD) in the general adult population. The PubMed and Web of Science databases were searched for prospective studies on GERD, heartburn, regurgitation, and dyspepsia, without any limitation on sample size. The Jadad scale was used to evaluate the quality of randomized controlled trials. In total, 13 prospective studies that were published in 12 articles were included in the analysis and scored per the Jadad scale as high- (five studies), medium- (two), and low- (six) quality. One article reported on two probiotic groups; thus, 14 comparisons were included in the selected studies, of which 11 (79%) reported positive benefits of probiotics on symptoms of GERD. Five out of 11 positive outcomes (45%) noted benefits on reflux symptoms: three noted reduced regurgitation; improvements in reflux or heartburn were seen in one study; five (45%) saw improvements in dyspepsia symptoms; and nine (81%) saw improvements in other upper gastrointestinal symptoms, such as nausea (three studies), abdominal pain (five), and gas-related symptoms (four), such as belching, gurgling, and burping. In conclusion, probiotic use can be beneficial for GERD symptoms, such as regurgitation and heartburn. However, proper placebo-controlled, randomized, and double-blinded clinical trials with a sufficient number of participants are warranted to confirm its efficacy in alleviating these symptoms. Further, interventions with longer durations and an intermediate analysis of endpoints should be considered to determine the proper therapeutic window.

show abstract

Section: Epidemiologymentioning

confidence: 99%

“…In addition, dietary supplements have been suggested to alleviate the severity and frequency of symptoms. Beneficial supplements include deglycerized licorice, glutamine, digestive enzymes, magnesium, and probiotics [9].…”

Section: Management and Treatmentmentioning

confidence: 99%

Gastroesophageal Reflux Disease and Probiotics: A Systematic Review

Cheng

Ouwehand

2020

Nutrients

View full text Add to dashboard Cite

show abstract

“…На сегодняшний день выделяют два основных фенотипа ГЭРБ: эрозивный рефлюкс-эзофагит, выявляемый примерно у 30% пациентов, а также неэрозивную рефлюксную болезнь, частота которой составляет до 70% случаев [11]. Текущие эпидемиологические данные свидетельствуют, что распространенность заболевания варьирует от 8,8 до 33,1%, а заболеваемость имеет неуклонную тенденцию к росту во всех регионах мира [3,12]. Наиболее высокие показатели распространенности регистрируются в развитых странах Европы и Северной Америки, а низкие -в развивающихся странах Азии [11,12].…”

Section: эпидемиология и факторы рискаunclassified

“…Помимо вышеназванного, терапия ИПП оказывает влияние лишь на секрецию соляной кислоты париетальными клетками желудка, при этом она не способна воздействовать на другие ключевые патофизиологические механизмы ГЭРБ, такие как учащение спонтанных релаксаций НПС, нарушения моторики пищевода и целостности эпителиального барьера [3,4,49,50].…”

Section: фармакотерапия: успехи и проблемыunclassified

“…рушением моторно-эвакуаторной функции органов гастроэзофагеальной зоны, приводящим к спонтанным и регулярно повторяющимся ретроградным забросам в пищевод желудочного и/или дуоденального содержимого, повреждающего слизистую оболочку дистального отдела пищевода [2,3]. Классическими клиническими проявлениями ГЭРБ являются изжога, отрыжка и регургитация (срыгивание), однако общий спектр симптоматики данного заболевания носит более широкий и гетерогенный характер, что нередко приводит к многочисленным диагностическим ошибкам [1,4].…”

unclassified

See 1 more Smart Citation

Current advances in the treatment of gastroesophageal reflux disease: a focus on esophageal protection

Маев

Andreev

Kucheryavy

et al. 2019

Terapevticheskii arkhiv

View full text Add to dashboard Cite

Gastroesophageal reflux disease (GERD) is characterized by high morbidity and a significant decrease in the quality of life of patients, and is a major risk factor for esophageal adenocarcinoma. Nowadays, antisecretory therapy with proton pump inhibitors (PPI) is the "gold standard" of conservative treatment of GERD, but in some cases this therapy is unsuccessful. According to various studies, the prevalence of refractory GERD can reach 30-40%. The latest scientific data in the field of genetics and pathophysiology of GERD demonstrate that a disruption of the barrier function of the esophageal mucosa and an increase of its permeability can be the leading causes of refractoriness. Thus, the optimal therapy for patients with GERD should not only suppress the secretion of hydrochloric acid, but also restore the barrier function of the mucous membrane, providing an esophagoprotective effect. To achieve these goals, Alfasoxx was developed, which consists of a mixture of low molecular weight hyaluronic acid and low molecular weight chondroitin sulfate dissolved in a bioadhesive carrier (poloxamer 407). The clinical efficacy of this product has been confirmed by three prospective, randomized, placebo - controlled trials. Alfasoxx has a healing and restorative effect towards the esophageal epithelium and due to high ability for bioadhesion provides long - term protection of the mucous membrane of the esophagus. Combination therapy for GERD with the use of PPI and an esophagoprotector offers new perspectives for the treatment of patients with GERD.

show abstract

Epidemiology and predictors of multimorbidity in Kharameh cohort study: A population‐based cross‐sectional study in southern Iran

Moftakhar

Rezaeianzadeh

Johari‬

et al. 2022

Health Science Reports

View full text Add to dashboard Cite

Background and Aim Multimorbidity is one of the problems and concerns of public health. The aim of this study was to estimate the prevalence and identify the risk factors associated with multimorbidity based on the data of the Kherameh cohort study. Methods This cross‐sectional study was performed on 10,663 individuals aged 40–70 years in the south of Iran in 2015 to 2017. Demographic and behavioral characteristics were investigated. Multimorbidity was defined as the coexistence of two or more of two chronic diseases in a person. In this study, the prevalence of multimorbidity was calculated. Logistic regression was used to identify the predictors of multimorbidity. Results The prevalence of multimorbidity was 24.4%. The age‐standardized prevalence rate was 18.01% in males and 29.6% in females. The most common underlying diseases were gastroesophageal reflux disease with hypertension (33.5%). Multiple logistic regression results showed that the age of 45–55 years (adjusted odds ratio [OR adj] ] = 1.22, 95% confidence interval [CI], 1.07–1.38), age of over 55 years (OR adj = 1.21, 95% CI, 1.06–1.37), obesity (OR adj = 3.65, 95% CI, 2.55–5.24), and overweight (OR adj = 2.92, 95% CI, 2.05–4.14) were the risk factors of multimorbidity. Also, subjects with high socioeconomic status (OR adj = 1.27, 95% CI, 1.1–1.45) and very high level of socioeconomic status (OR adj = 1.53, 95% CI, 1.31–1.79) had a higher chance of having multimorbidity. The high level of education, alcohol consumption, having job, and high physical activity had a protective role against it. Conclusion The prevalence of multimorbidity was relatively high in the study area. According to the results of our study, age, obesity, and overweight had an important effect on multimorbidity. Therefore, determining interventional strategies for weight loss and control and treatment of chronic diseases, especially in the elderly, is very useful.

show abstract

Natural history, pathophysiology and evaluation of gastroesophageal reflux disease

Cited by 48 publications

References 80 publications

Gastroesophageal Reflux Disease and Probiotics: A Systematic Review

Gastroesophageal Reflux Disease and Probiotics: A Systematic Review

Current advances in the treatment of gastroesophageal reflux disease: a focus on esophageal protection

Epidemiology and predictors of multimorbidity in Kharameh cohort study: A population‐based cross‐sectional study in southern Iran

Contact Info

Product

Resources

About