Natural history of solitary cerebral cysticercosis on serial magnetic resonance imaging and the effect of albendazole therapy on its evolution

Souza, Aaron de; Nalini, Atchayaram; Kovoor, J.M.E.; Yeshraj, G.; Siddalingaiah, H S; Thennarasu, K

doi:10.1016/j.jns.2009.09.018

Cited by 36 publications

(43 citation statements)

References 34 publications

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“…Demographic data are presented in Table 1, and there was no statistically significant difference between the treatment and control groups. All cysts at enrolment were active, in stages 2 or 3 as per the classification proposed by us previously 6 .…”

Section: Resultsmentioning

confidence: 99%

“…Patients were imaged at least 24 hours after the last seizure. The stage of the lesion was determined based on the criteria proposed by us previously 6 . The patients were randomized to two groups by means of a random-number table consisting of 200 random numbers: one group received antiepileptic drugs only (usually phenytoin or carbamazepine/oxcarbazepine) and the second group was given albendazole 15 mg/kg/day in two divided doses for 28 days in addition to antiepileptic medication.…”

Section: Methodsmentioning

confidence: 99%

“…The average T2 value of stage 2 lesions (corresponding to Escobar's colloid-vesicular stage) 6,12 was 321 ms, that of stage 3 (granular nodular) lesions was 389 ms and that of stage 4 (nodular calcified) lesions was 84 ms. Normal grey matter had a slightly higher mean T2 value than white matter. The wall of the lesion on the initial MRI showed a mean T2 value of 152.3 ms, while the centre of the lesion and the perilesional parenchyma had values of 474.9 and 338.5 ms respectively.…”

Section: Serial Quantitative T2 Relaxometrymentioning

confidence: 95%

“…Computed tomography and magnetic resonance imaging (MRI) are useful investigations for diagnosing NC 3 , but MRI is considered the investigation of choice for studying the evolution of cyst as well as the effect of medication 4,5 . Although the natural history of NC has been studied using serial CT and MRI 6 , newer quantitative techniques have been infrequently used to prospectively study the evolution of these lesions. Magnetization transfer imaging (MTI) has proven useful in delineating gliosis around the SCCL which is seen as a hyperintense signal barely visible on conventional T2-weighted imaging [7][8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

“…The present study is part of a prospective randomized controlled trial of albendazole in a cohort of patients with SCCL and new-onset seizures. We previously reported the effect of cysticidal therapy with albendazole on the evolution of the cysticercal lesion on serial conventional MRI 6 and on MTI 10 . This paper presents the evolution of quantitative T2 relaxation (T2R) values over a period of 24 months in patients with SCCL.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Quantitative Serial T2 Relaxometry: A Prospective Evaluation in Solitary Cerebral Cysticercosis

Nalini¹,

Souza²,

Saini³

et al. 2014

Neuroradiol J

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Serial Quantitative T2 Relaxometrymentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Quantitative Serial T2 Relaxometry: A Prospective Evaluation in Solitary Cerebral Cysticercosis

Nalini¹,

Souza²,

Saini³

et al. 2014

Neuroradiol J

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Anthelmintics for people with neurocysticercosis

Abba¹,

Ramaratnam²,

Ranganathan³

2010

Cochrane Database of Systematic Reviews

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Anthelmintics for people with neurocysticercosis

Abba

Ranganathan

2021

Cochrane Database of Systematic Reviews

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Background Neurocysticercosis is a parasitic infection of the central nervous system by the larval stage of the pork tapeworm and is a common cause of seizures and epilepsy in endemic areas. Anthelmintics (albendazole or praziquantel) may be given alongside supportive treatment (antiepileptics/analgesia) with the aim of killing these larvae (cysticerci), with or without corticosteroid treatment. However, there are potential adverse effects of these drugs, and the cysticerci may eventually die without directed anthelminthic treatment. Objectives To assess the effects of anthelmintics on people with neurocysticercosis. Search methods We searched the Cochrane Infectious Diseases Group Specialized Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, LILACS, the WHO ICTRP, and ClinicalTrials.gov, up to 21 October 2020. Selection criteria Randomized controlled trials comparing anthelmintics and supportive treatment (+/‐ corticosteroids) with supportive treatment alone (+/‐ corticosteroids) for people with neurocysticercosis. Data collection and analysis Two review authors independently screened the title and abstract of all articles identified by the search. We obtained full‐text articles to confirm the eligibility of all studies that passed screening. One review author extracted data, which a second review author checked. Two review authors assessed the risk of bias of each trial and performed GRADE assessments. In cases of disagreement at consensus discussion stage between review authors, we consulted a third review author. We calculated risk ratios (RR) for dichotomous variables, with 95% confidence intervals (CIs) for pooled data from studies with similar interventions and outcomes. Main results We included 16 studies in the review. Only two studies investigated praziquantel and did not report data in a format that could contribute to meta‐analysis. Most results in this review are therefore applicable to albendazole versus placebo or no anthelmintic. The aggregate analysis across all participants with neurocysticercosis did not demonstrate a difference between groups in seizure recurrence, but heterogeneity was marked (RR 0.94, 95% CI 0.78 to 1.14; 10 trials, 1054 participants; I 2 = 67%; low‐certainty evidence). When stratified by participants with a single cyst or multiple cysts, pooled analysis suggests that albendazole probably improves seizure recurrence for participants with a single cyst (RR 0.61, 95% CI 0.4 to 0.91; 5 trials, 396 participants; moderate‐certainty evidence). All studies contributing to this analysis recruited participants with non‐viable, intraparenchymal cysts only, and most participants were children. We are uncertain whether or not albendazole reduces seizure recurrence in participants with multiple cysts, as the certainty of the evidenc...

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Natural history of solitary cerebral cysticercosis on serial magnetic resonance imaging and the effect of albendazole therapy on its evolution

Cited by 36 publications

References 34 publications

Quantitative Serial T2 Relaxometry: A Prospective Evaluation in Solitary Cerebral Cysticercosis

Quantitative Serial T2 Relaxometry: A Prospective Evaluation in Solitary Cerebral Cysticercosis

Anthelmintics for people with neurocysticercosis

Anthelmintics for people with neurocysticercosis

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