Natural History of Low-Grade Squamous Intraepithelial Lesion

Saw, Ho-Suk; Lee, Jae Kwan; Lee, Hwa-Lynn; Jee, Hyun–Jun; Hyun, Jong-Jin

doi:10.1046/j.1526-0976.2001.53007.x

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…This progression rate of 14.5% seems high, given that Saw et al. 19 have observed a progression rate of 11% for CIN1 lesions over a follow‐up of 60 months, in a study on the natural history of CIN lesions without treatment. A possible explanation of the fact that our progression rate did not diminish with treatment is the use of a single‐freeze technique, according to national policy, whereas in other study protocols a double‐freeze technique has been used.…”

Section: Discussionmentioning

confidence: 83%

Natural history and clearance of HPV after treatment of precancerous cervical lesions

et al. 2008

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Section: Discussionmentioning

confidence: 83%

Natural history and clearance of HPV after treatment of precancerous cervical lesions

et al. 2008

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“…There are 2 possibilities for the development of LSIL, which are: experiencing regression or progressing to HSIL. Observation of LSIL for 5 years showed 10.7% progressed to HSIL, 55% experienced persistence and 34.2% regressed to normal (Saw et al, 2001). In the old pap smear reading system, there are 3 main categories of cervical precancerous lesions, namely CIN I, II and III.…”

mentioning

confidence: 99%

A Case Report: Conservative Treatment Modalities as Loop Electrosurgical Excision Procedure (LEEP) Can Be Used to Treat Precancer Cervix Lesion High Grade Squamous Intraepithelial Lesion (HSIL) or Moderate and Severe Dysplasia (CIN II and III) with Post Coital Bleeding Disorders

Supriyono¹

2021

IJRP

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Human Papillomavirus Testing for Cervical Cancer Screening: Results From a 6-Year Prospective Study in Rural China

Shi¹,

Belinson²,

Zhao³

et al. 2009

American Journal of Epidemiology

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Long-term follow-up evaluations of cervical screening approaches are limited in low-resource areas. This prospective study assessed the risk of future cervical intraepithelial neoplasia grade 2 or worse (CIN2+) associated with baseline human papillomavirus (HPV) and cytologic status. In rural China, 1,997 women were screened with 6 screening tests, including colposcopic evaluations, and underwent biopsies in 1999. In December 2005, 1,612 women with cervical intraepithelial neoplasia grade 1 or less at baseline were rescreened by visual inspection, liquid-based cytology, and HPV-DNA testing. All women underwent colposcopy at follow-up, with biopsies taken from women with visually apparent lesions or cytologic abnormalities. Twenty women developed incident CIN2+. The crude relative risk of CIN2+ for baseline HPV-positive women was 52 (95% confidence interval: 12.1, 222.5). The crude relative risk of CIN2+ was 167 (95% confidence interval: 21.9, 1,265) for baseline and follow-up repeatedly HPV-positive women compared with repeatedly HPV-negative women. Among 1,374 baseline HPV-negative women, 2 and no incident CIN2+ cases were detected in baseline cytologically normal and abnormal subgroups, respectively. Among 238 baseline HPV-positive women, 6 of 18 incident cases of CIN2+ developed in the cytologically normal group. This study demonstrates that a single oncogenic HPV-DNA test is more effective than cytology in predicting future CIN2+ status.

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Natural History of Low-Grade Squamous Intraepithelial Lesion

Abstract: Of the patients who were diagnosed with CIN1 and monitored by colposcopy for 60 months, 34% had disease regression, 55% had persistent disease, and 11% had progressive disease. HPV DNA testing is more informative than the Pap test in the prediction of disease progression.

Cited by 3 publications

References 19 publications

Natural history and clearance of HPV after treatment of precancerous cervical lesions

Natural history and clearance of HPV after treatment of precancerous cervical lesions

A Case Report: Conservative Treatment Modalities as Loop Electrosurgical Excision Procedure (LEEP) Can Be Used to Treat Precancer Cervix Lesion High Grade Squamous Intraepithelial Lesion (HSIL) or Moderate and Severe Dysplasia (CIN II and III) with Post Coital Bleeding Disorders

Human Papillomavirus Testing for Cervical Cancer Screening: Results From a 6-Year Prospective Study in Rural China

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