Natural history of “intrinsic” atopic dermatitis

Novembre, Elio; Cianferoni, Antonella; Lombardi, Enrico; Bernardini, Roberto; Pucci, Neri; Vierucci, A

doi:10.1034/j.1398-9995.2001.056005452.x

Cited by 113 publications

(100 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the other hand, the context of atopic march has been challenged by the presence of eczema cases that have clinically similar findings with atopic patients but are non-atopic [2]. In a previous study, it has been reported that 25% of late-onset and 59% of early-onset atopic children with eczema developed asthma while none of the non-atopic ones did [14]. There is some evidence to increased risk of allergic respiratory diseases in extrinsic AD cases [15].…”

Section: Discussionmentioning

confidence: 99%

“…However, AD may or may not be associated with high IgE levels and allergic sensitization [2]. The frequency of the nonallergic or intrinsic dermatitis is around 5.4% in adults but is expected to be much higher in young children [2,3,14]. It is considered to comprise two thirds of all AD cases when population-based studies are considered instead of the hospital-based ones [15].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Characteristics and Prognosis of Childhood Atopic Dermatitis: A Multicenter Study in Turkey

Yüksel

Can

Reisli

et al. 2010

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background:Childhood atopic dermatitis (AD) is classically accepted as initial finding of atopic march; however, nonatopic cases do not follow this course. The aim of this study was to determine the characteristics and prognosis of AD in childhood in Turkey. Methods:The study included 531 children with AD that presented to pediatric allergy departments in 11 different regions of Turkey. Age at diagnosis, total serum and inhalant-specific immunoglobulin E (IgE) levels and allergen skin prick test results were recorded retrospectively. Clinical characteristics like additional allergic diseases at presentation or during follow-up were recorded as well as duration of follow-up. Results:Mean age at diagnosis was 37.8 ± 36.2 months. Mean IgE level was 318.3 ± 677.8 IU/ml (median 100 IU/ml). Skin prick tests yielded positive results in 47% of children. At presentation, 31.6% of children reported additional allergic disease, while 11.7% developed allergic disease during follow-up. Among all, 46.6% had additional allergic disease at any point. IgE levels were significantly higher in children with additional allergic diseases (p = 0.001). Allergen skin prick test positivity and family history of allergic diseases increased the risk of additional allergic diseases significantly (OR = 3.90, 95% CI = 2.3–6.6 and OR = 1.89, 95% CI = 1.3–2.8, respectively). Conclusions: Allergic sensitization is not present in all cases of AD. Coexistence of additional allergic diseases is not as high as expected but more common in children who have been demonstrated to have atopic sensitization with high IgE levels and allergen skin prick test positivity.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Characteristics and Prognosis of Childhood Atopic Dermatitis: A Multicenter Study in Turkey

Yüksel

Can

Reisli

et al. 2010

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…After review of the titles and abstracts, 9326 were excluded; an additional 634 articles were excluded after full-text review. In total, 46 studies were included in the review, of which 44 had valid frequency data that could be pooled, 7 had valid data to assess the effects of gender, 6,23,28,31,44,45,48 6 for allergen sensitization, 6,17,23,36,40,45 and 3 for baseline AD severity 17,28,40 on disease persistence. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram is presented in Fig 1. …”

Section: Literature Searchmentioning

confidence: 99%

Persistence of atopic dermatitis (AD): A systematic review and meta-analysis

Kim

Chao

Simpson

et al. 2016

Journal of the American Academy of Dermatology

205

156

View full text Add to dashboard Cite

show abstract

“…Nevertheless, 16-45% of children with eczema show normal IgE [9,10]. Although recent studies suggest that there might be a dynamic connection between the extrinsic (elevated serum IgE levels) and the intrinsic (normal serum IgE levels) AD [11], it has not been evaluated at present whether patients with intrinsic AD, in contrast to patients with extrinsic AD, have a higher risk of family recurrence or having allergic rhinitis or allergic asthma developing later.…”

Section: Introductionmentioning

confidence: 99%