Natural History of Human Filariasis — The Elusive Road

Abstract

There are currently two models to explain the course of lymphatic filarial infection and disease in human populations. I develop a different model that incorporates existing data from animal models as well as epidemiological and longitudinal observations on human populations. The model explains the observations and makes predictions which are testable.

Protective immunity in human lymphatic filariasis: problems and prospects

“…Unlike several other infectious diseases, there is no clear consensus that patent infections would necessarily lead to development of chronic disease in human lymphatic filariasis [36]. This is partly due to limitations in defining protective immunity in human communities.…”