Aping Jane Goodall: insights into human lymphatic filariasis

Ravindran, Balachandran

doi:10.1016/s1471-4922(03)00004-7

Cited by 18 publications

(11 citation statements)

References 20 publications

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“…A study conducted by Okajima et al 35 demonstrated that the mean time of hospitalization of patients with erysipelas is 9.9 days, with an average cost of US$ 249.51 for a single treatment. Patients in India reduce their workload by 11 to 33% annually with the complications of lymphedema 36,37 . Another study conducted at the same site reveals that men with lymphedema had a 27% decrease in productivity when compared to controls38.…”

Section: Discussionmentioning

confidence: 99%

Terapia complexa descongestiva com uso de material alternativo na redução e controle do linfedema em pacientes de área endêmica de filariose: um ensaio clínico

et al. 2016

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RESUMO A filariose linfática põe em risco bilhões de pessoas em todo o mundo. Apesar disso, pouco se sabe sobre o impacto da morbidade crônica da doença, como o linfedema. A terapia complexa descongestiva apresenta-se como padrão ouro para tratar linfedemas, mas ainda não existem protocolos viáveis para implementação em países em desenvolvimento. O objetivo deste ensaio clínico foi avaliar a eficácia dessa técnica, com o uso de material alternativo, e comparar seus efeitos na qualidade de vida, funcionalidade e peso corporal. Os grupos intervenção e controle foram avaliados por meio de perimetria e cálculo do volume dos membros, do questionário de qualidade de vida Whoqol-bref, do teste de funcionalidade e mobilidade de membros inferiores Timed Up and Go e avaliação do peso corporal. O grupo intervenção recebeu a terapia complexa descongestiva duas vezes por semana, durante dez semanas, utilizando-se um material alternativo para o enfaixamento, confeccionado com tecido de cambraia, o que apresenta baixo custo em relação às faixas importadas. O grupo controle recebeu palestra com informações sobre a doença e orientações de cuidados e higiene dos membros. A amostra foi composta por trinta pacientes com idade média de 50,8±10 anos, sendo 52,9% mulheres. Na análise estatística foram utilizados os testes t de Student, Multivariate analysis of variance, teste de Wilcoxon e Kolmogorov-Smirnov. A significância adotada foi de 5% (p<0,05). Houve redução significativa do volume e perimetria do linfedema no grupo intervenção, e aumentou no grupo controle. A funcionalidade não apresentou melhora significativa na avaliação pelo teste Timed Up and Go. A qualidade de vida teve melhora significativa nos domínios físico e meio ambiente no grupo intervenção. O efeito do tratamento no peso corporal também foi significativo, apresentando redução no grupo controle e intergrupos. A terapia complexa descongestiva mostrou-se eficaz na redução e no controle do linfedema e impactou de maneira positiva, aumentando os valores numéricos dos aspectos físico e meio ambiente da qualidade de vida do grupo intervenção.

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Section: Discussionmentioning

confidence: 99%

Terapia complexa descongestiva com uso de material alternativo na redução e controle do linfedema em pacientes de área endêmica de filariose: um ensaio clínico

et al. 2016

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“…Longitudinal studies showing that asymptomatic microfilaraemic persons are less likely than uninfected persons to develop lymphoedema suggest an immunologic mechanism [99]. Recent studies also have suggested a possible role for Wolbachia in the pathogenesis of lymphoedema [19,20].…”

Section: Lymphoedemamentioning

confidence: 99%

Morbidity management in the Global Programme to Eliminate Lymphatic Filariasis: a review of the scientific literature

2007

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The Global Programme to Eliminate Lymphatic Filariasis (GPELF) has two major goals: to interrupt transmission of the parasite and to provide care for those who suffer the devastating clinical manifestations of the disease (morbidity control). This latter goal addresses three filariasis-related conditions: acute inflammatory episodes; lymphoedema; and hydrocele. Research during the last decade has confirmed the importance of bacteria as a cause of acute inflammatory episodes in filariasis-endemic areas, known as acute dermatolymphangioadenitis (ADLA). Current lymphoedema management strategies are based on the central role of ADLA as a trigger for lymphoedema progression. Simple intervention packages are in use that have resulted in dramatic reductions in ADLA rates, a lower prevalence of chronic inflammatory cells in the dermis and subdermis, and improvement in quality of life. During the past decade, the socioeconomic impact of ADLA and lymphoedema in filariasis-endemic areas has received increasing attention. Numerous operational research questions remain to be answered regarding how best to optimize, scale up, monitor, and evaluate lymphoedema management programmes. Of the clinical manifestations targeted by the GPELF, hydrocele has been the focus of the least attention. Basic information is lacking on the effectiveness and complications of hydrocele surgery and risk of post-operative hydrocele recurrence in filariasis-endemic areas. Data on the impact of mass administration of antifilarial drugs on filarial morbidity are inconsistent. Several studies report reductions in acute inflammatory episodes, lymphoedema, and/or hydrocele following mass drug administration, but other studies report no such association. Assessing the public health impact of mass treatment with antifilarial drugs is important for programme advocacy and morbidity control strategies. Thus, although our knowledge of filariasis-related morbidity and its treatment has expanded in recent years, much work remains to be done to address the needs of more than 40 million persons who suffer worldwide from these conditions.

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“…Currently, 120 million people are infected with Wuchereria bancrofti in about 83 endemic countries (Michael et al 1996), and it is estimated that 40 million people have evidence of chronic manifestations such as hydrocele and lymphoedema/ elephantiasis. Besides this, affected individuals suffer repeated episodes of adenolymphangitis (acute attacks), which result in less man hours of work, depleting their income (Ravindran 2003). World Health Assembly passed a resolution (WHA: 50.29) on elimination of LF as a public health problem by the year 2020.…”

Section: Introductionmentioning

confidence: 99%

Filaria Monitoring Visualization System: A Geographical Information System–Based Application to Manage Lymphatic Filariasis in Andhra Pradesh, India

Upadhyayula

Mutheneni²,

Kumaraswamy³

et al. 2012

Vector-Borne and Zoonotic Diseases

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Among various public health diseases, filariasis constitutes a major public health problem in India, wherein an estimated 553.7 million people are at risk of infection. The aim of this article is to present a spatial mapping and analysis of filariasis data over a 3-year period (2004-2007) from Karimnagar, Chittoor, East and West Godavari districts of Andhra Pradesh, India. The data include epidemiological and entomological studies (i.e., infection rate, infectivity rate, mosquito per man hour, and microfilaria rate). These parameters were customized on Geographical Information System (GIS) platform and developed filaria monitoring visualization system (FMVS) for identifying the endemic/risk areas of filariasis among these four districts. GIS map for filariasis transmission from the study areas was created and stratified into different spatial entities like low, medium, and high risk zones. On the basis of the data and FMVS maps, it was demonstrated that filariasis remained unevenly distributed within the districts. Balancing the intervention coverage in different villages with overall mass drug administration and continued promotion of the proper use of control measures are necessary for further reduction of filarial cases in these districts.

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Aping Jane Goodall: insights into human lymphatic filariasis

Cited by 18 publications

References 20 publications

Terapia complexa descongestiva com uso de material alternativo na redução e controle do linfedema em pacientes de área endêmica de filariose: um ensaio clínico

Terapia complexa descongestiva com uso de material alternativo na redução e controle do linfedema em pacientes de área endêmica de filariose: um ensaio clínico

Morbidity management in the Global Programme to Eliminate Lymphatic Filariasis: a review of the scientific literature

Filaria Monitoring Visualization System: A Geographical Information System–Based Application to Manage Lymphatic Filariasis in Andhra Pradesh, India

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