Natural history of breast cancer:Progression from hyperplasia to neoplasia as predicted by angiogenesis

Gullino, Pietro M.

doi:10.1002/1097-0142(197706)39:6<2697::aid-cncr2820390656>3.0.co;2-4

Cited by 81 publications

(14 citation statements)

References 26 publications

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“…In contrast, results from Sweden demonstrate a worse OS for patients diagnosed in the summer probably due to a relative reduction in the number of early stage diagnoses from mammography screening which are closed in the summer months and the healthcare system treating primarily the most sick patients in holiday periods 23 30. Breast cancer is regarded as a relatively slow growing cancer, with a long preclinical course 31. If vitamin D level should be of etiologic or prognostic importance, it is supposed that the influence is working over a longer time period and not just reflected by vitamin D status at time of diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Breast cancer survival and season of surgery: an ecological open cohort study

Teilum¹,

Bjerre

Tjønneland

et al. 2012

BMJ Open

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Background: Vitamin D has been suggested to influence the incidence and prognosis of breast cancer, and studies have found better overall survival (OS) after diagnosis for breast cancer in summereautumn, where the vitamin D level are expected to be highest.Objective: To compare the prognostic outcome for early breast cancer patients operated at different seasons of the year.Design: Open population-based cohort study. Setting: Danish women operated 1978e2010. Cases: 79 658 adjusted for age at surgery, period of surgery, tumour size, axillary lymph node status and hormone receptor status. Statistical analysis:The association between OS and season of surgery was analysed by Cox proportional hazards regression models, at survival periods 0e1, 0e2, 0e5 and 0e10 years after surgery. A two-sided p value <0.05 was considered statistical significant.Results: Only after adjustment for prognostic factors that may be influenced by vitamin D, 1-year survival was close to significantly associated season of surgery. 2, 5 and 10 years after surgery, the association between OS and season of surgery was not significant. Limitations:Season is a surrogate measure of vitamin D. Conclusions:The authors found no evidence of a seasonal variation in the survival after surgery for early breast cancer. Lack of seasonal variation in this study does not necessarily mean that vitamin D is of no importance for the outcome for breast cancer patients.

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Section: Discussionmentioning

confidence: 99%

Breast cancer survival and season of surgery: an ecological open cohort study

Teilum¹,

Bjerre

Tjønneland

et al. 2012

BMJ Open

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“…The patients were comparable in terms of age and tumor size (Figs 1 and 2). 7. All patients were treated, after biopsy-proven diagnosis of invasive infiltrating breast cancer, by standard radical mastectomy or ultraradical mastectomy.…”

Section: Methodsmentioning

confidence: 99%

The Treatment of Breast Cancer:

Peterson

1988

Arch Surg

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“…During malignant progression of mammary tissue there is a concomittant increase in angiogenic activity of the tumor tissue (120)(121)(122)(123), and Ziche and Gullino's studies (124) indicate that the angiogenic potential of human, murine and hamster cells develops as an early sign of transformation in vitro, and correlates with neoplastic progression.…”

Section: B Explantation and Subsequent Transplantationmentioning

confidence: 99%

Invasiveness of transformed bladder epithelial cells

Kieler

1984

Cancer Metast Rev

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The invasiveness of bladder tumors has been studied in man, experimental animals, and in tissue culture by numerous authors. The prognostic importance of cellular markers for invasiveness is stressed, and the usefulness of histopathological and cytologic grading, cytogenetic studies, antigenic investigations, and enzymatic characterization is discussed. The invasiveness of bladder cells has frequently been examined in transplantation and explantation experiments. In human urothelial cell cultures three grades of transformation are defined, and a correlation has been established between the invasiveness of these cell lines in a three-dimensional in vitro model and their tumorigenicity in nude mice. The mechanism of tumor invasion is discussed, and it is recommended in future research to make a distinction between invasion en bloc and cellular infiltration.

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Natural history of breast cancer:Progression from hyperplasia to neoplasia as predicted by angiogenesis

Abstract: The age-adjusted death rate of women with breast cancer has not improved appreciably over the last 20 years. The average duration of life for untreated

Cited by 81 publications

References 26 publications

Breast cancer survival and season of surgery: an ecological open cohort study

Breast cancer survival and season of surgery: an ecological open cohort study

The Treatment of Breast Cancer:

Invasiveness of transformed bladder epithelial cells

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