The Treatment of Breast Cancer:

Peterson, Clare G.

doi:10.1001/archsurg.1988.01400330035004

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1990

2000

Publication Types

Select...

Article2

Book2

Relationship

Self Cite0

Independent4

Authors

Journals

Cited by 4 publications

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Icons in Surgery

Peterson

1992

Arch Surg

View full text Add to dashboard Cite

This company of surgeons, the Pacific Coast Surgical Association, has honored me greatly, and I am grateful. In a turbulent, changing world, as physicians, you are among the most important people on earth. More important, by far, than any technologic aspect of your craft, is your character. As the pen is mightier than the sword, your beliefs and values are the sustaining force that will guide you in troubled times. Icons are Everyman's "pointers of the way" in meeting the challenges of tomorrow.

show abstract

Icons in Surgery

Peterson

1992

Arch Surg

View full text Add to dashboard Cite

show abstract

Dormancy and breast cancer

Meltzer

1990

Journal of Surgical Oncology

View full text Add to dashboard Cite

A case is presented in which multiple nodules of recurrent cancer appeared about the scar 25 years after radical mastectomy. They were accompanied by an inflammatory reaction. Breast cancers may recur as long as 50 years after surgery. Such late recurrence is accomplished by the cancer cell entering a "dormant" state in which little or no de novo DNA transcription occurs and only enough RNA is translated into proteins to maintain the vegetative functions that sustain cell viability. Features favoring the evolvement of dormancy are discussed as well as the nature of the cocoon-like shell which affords such cancer cells protection from the host's cellular and serological defenses. Speculation, promoted by the new cellular biology, as to the cause of secondary inflammatory cancers, is presented. A possible mechanism for the reactivation of these quiescent cells is suggested. The altered immune reactions of host and cancer cells provide an explanation for the controversies plaguing surgeons regarding the treatment and prognosis of breast cancer.

show abstract