Natural history of bleeding after esophageal variceal eradication in patients with extrahepatic portal venous obstruction; a 20-year follow-up

Varghese, Thomas; Jose, Tony; Kumar, Sunil

doi:10.1007/s12664-009-0086-0

Cited by 35 publications

(32 citation statements)

References 21 publications

(36 reference statements)

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“…114 Bleeding after initial variceal eradication occurs usually within first 4-10 years and the risk of bleeding reduces as age progresses especially after 10 years. 115 Liver dysfunction in long term is a concern and other long term consequences in nutrition, mental function and portal biliopathy.…”

Section: Chronic Portal Vein Thrombosismentioning

confidence: 99%

Portal Vein Thrombosis

Chawla

Bodh

2015

Journal of Clinical and Experimental Hepatology

150

147

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Portal vein thrombosis is an important cause of portal hypertension. PVT occurs in association with cirrhosis or as a result of malignant invasion by hepatocellular carcinoma or even in the absence of associated liver disease. With the current research into its genesis, majority now have an underlying prothrombotic state detectable. Endothelial activation and stagnant portal blood flow also contribute to formation of the thrombus. Acute non-cirrhotic PVT, chronic PVT (EHPVO), and portal vein thrombosis in cirrhosis are the three main variants of portal vein thrombosis with varying etiological factors and variability in presentation and management. Procoagulant state should be actively investigated. Anticoagulation is the mainstay of therapy for acute non-cirrhotic PVT, with supporting evidence for its use in cirrhotic population as well. Chronic PVT (EHPVO) on the other hand requires the management of portal hypertension as such and with role for anticoagulation in the setting of underlying prothrombotic state, however data is awaited in those with no underlying prothrombotic states. TIPS and liver transplant may be feasible even in the setting of PVT however proper selection of candidates and type of surgery is warranted. Thrombolysis and thrombectomy have some role. TARE is a new modality for management of HCC with portal vein invasion. ( J CLIN EXP HEPATOL 2015;5:22-40)

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Section: Chronic Portal Vein Thrombosismentioning

confidence: 99%

Portal Vein Thrombosis

Chawla

Bodh

2015

Journal of Clinical and Experimental Hepatology

150

147

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“…In the younger age group (<20yrs), early appearance of varices / PHTN is due to NCPF (Non-cirrhotic portal fibrosis) and EHPVO (Extra-hepatic portal vein obstruction) which could be attributed to nutritional deficiencies / infection. 20,21 Highest incidence of infections was to be found in 31-40-year age group. The patients who were immunocompromized/susceptible to infection showed infections like candidiasis.…”

Section: -18mentioning

confidence: 99%

Pattern of upper gastrointestinal diseases: an audit of 1000 cases based on endoscopic findings from a tertiary care hospital in Mysore

2018

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Background: Fibreoptic endoscopy is a highly efficient diagnostic tool, which is now increasingly being used in the diagnosis of upper gastrointestinal diseases. This study has been carried out to evaluate the distribution of various upper gastrointestinal diseases based on endoscopic findings in a tertiary care hospital in Mysore.Methods: A cross-sectional study was conducted based on data from endoscopic register of 1000 subjects who underwent endoscopy for various upper gastrointestinal symptoms from 1st January 2017 to 31st December 2017(one year).Results: Mean age of the study population was 50.23 years (SD-15.46). Minimum age was 12 years and maximum was 88 years. About 44.7% of the study subjects belonged to 40-60 age group.61.6% of the study subjects were males. Most common indication was pain abdomen (32.1%) followed by dysphagia (22.2%). Of the 1000 study subjects 18.6% had normal findings. Most common finding was Gastritis / Duodenitis /Gastric erosions (28%). Malignant lesions were noted among 11.1%, of which esophagus and stomach are 5.4% and 4.9% respectively.Conclusions: Endoscopic diagnosis is useful for early detection of UGI diseases and helpful for their management.

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“…Though many recent studies have shown almost comparable rates of control of acute bleed, rebleed and overall long term survival with endoscopic variceal sclerotherapy, 13 yet in a country like India, where expert endoscopic therapy and blood banking facilities in many remote areas are still sub optimal, a onetime surgical procedure in the form of a splenectomy and portosystemic shunt, in those with good liver function like EHPVO or NCPF is still a better option. Moreover, the control of portal hypertensive gastropathy, portal biliopathy and growth retardation in these patients can be addressed only by a portosystemic shunt.…”

Section: Long Term Survivalmentioning

confidence: 99%

Portal hypertension

Banerjee

2012

Medical Journal Armed Forces India

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Natural history of bleeding after esophageal variceal eradication in patients with extrahepatic portal venous obstruction; a 20-year follow-up

Cited by 35 publications

References 21 publications

Portal Vein Thrombosis

Portal Vein Thrombosis

Pattern of upper gastrointestinal diseases: an audit of 1000 cases based on endoscopic findings from a tertiary care hospital in Mysore

Portal hypertension

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