Natural history of arteriovenous malformations: analysis of non-radically treated patients

Yamane, Fumitaka; Takeshita, Mikihiko; Izawa, Masahiro; Kagawa, Mizuo; Sato, Kazuei; Takakura, Kintomo

doi:10.1016/s0967-5868(98)90006-6

Cited by 12 publications

(11 citation statements)

References 10 publications

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“…Estimates of the rate of cerebral AVM hemorrhage vary significantly depending on whether the analysis aims to report the cumulative or per annum risk [32][33][34][35], and the inclusion of recurrent and previous hemorrhages [7]. Given their relative rarity, confusion among classification systems [10], and the small number of modern clinical series with any natural history data, it is even more difficult to estimate the innate rate of bleeding for SCAVM.…”

Section: Discussionmentioning

confidence: 99%

CyberKnife Ablation for Intramedullary Spinal Cord Arteriovenous Malformations (AVMs): A New Promising New Therapeutic Approach

Adler¹,

Gupta²,

Chang³

et al. 2010

Cureus

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Section: Discussionmentioning

confidence: 99%

CyberKnife Ablation for Intramedullary Spinal Cord Arteriovenous Malformations (AVMs): A New Promising New Therapeutic Approach

Adler¹,

Gupta²,

Chang³

et al. 2010

Cureus

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“…It is sometimes concluded that the risk rises with age, 9,21a declines, or is static after an early peak. 3,8,16,21 Variable inclusion of recurrent and previous hemorrhage may explain the variations.…”

Section: Risk Of First Hemorrhage In Untreated Patientsmentioning

confidence: 99%

“…23,24 These patients, together with incompletely treated and conservatively managed patients, remain at risk of new or recurrent hemorrhage. 21 Without prolonged follow-up with good-quality imaging, a false presumption of clinical cure may occur. lowered if patients are warned of the risk of anticoagulant therapy.…”

Section: Hemorrhage After Diagnosismentioning

confidence: 99%

A Population-Based Study of Brain Arteriovenous Malformation

ApSimon

Reef

Phadke

et al. 2002

Stroke

197

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Background and Purpose— By undertaking long-term follow-up of a functionally isolated population study group, we sought to achieve a true picture of intrinsic brain arteriovenous malformation (BAVM). We sought to assess the validity of earlier population-based series and to determine the effects of newer treatment methods on the overall morbidity and mortality of BAVM. Methods— We excluded other intracranial vascular pathologies by defining criteria. By retrospective and prospective study, 240 patients with BAVM were followed for a mean of 10.11 years from first diagnosis. Results— Death rates were as follows: all causes, 12.9%; all BAVM related, 8.75%; BAVM related during conservative management, 24.6%; and BAVM related during active management, 3.9% ( P =0.031). Mean diagnosis-to-death interval was 10.6 years. Oxford neurological disability scale grades of 209 survivors (July 2001) were as follows: grades 0 to 2, 74.1%; grade 3, 17.2%; and grades 4 to 5, 9.5%. Death rates were higher for patients who had bled or suffered nonhemorrhagic neurological deficit at original presentation. Incidence of first-ever hemorrhage in untreated patients was as follows: 0 to 9 years, 4.6% ( P =0.0035); 30 to 39 years, 21% ( P =0.02); and 60 to 69 years, 40.0% ( P =0.045). The first bleed was fatal in 4.6%. Conclusions— We find no evidence of a substantial undiagnosed reservoir of nonsymptomatic BAVM. All BAVM are potentially hazardous. The great majority of BAVM patients become symptomatic during the patient’s lifetime, and the majority will bleed. The risk of first hemorrhage is lifelong and rises with age. Compared with earlier population-based series, our low overall patient mortality is predominantly due to higher proportions of active treatment in the 1980s and 1990s.

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“…About half of the patients with arteriovenous malformations (AVM) present with acute hemorrhage, [1][2][3] and CT angiography has attained considerable importance in the early diagnosis of these lesions. 4 Work-up of the remaining patients is often initiated with MRI, in the context of seizure, focal neurologic deficit or headache.…”

Section: Introductionmentioning

confidence: 99%

Sensitivity of CT angiography, T2-weighted MRI, and magnetic resonance angiography in detecting cerebral arteriovenous malformations and associated aneurysms

Gross

Frerichs

2012

Journal of Clinical Neuroscience

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Natural history of arteriovenous malformations: analysis of non-radically treated patients

Cited by 12 publications

References 10 publications

CyberKnife Ablation for Intramedullary Spinal Cord Arteriovenous Malformations (AVMs): A New Promising New Therapeutic Approach

CyberKnife Ablation for Intramedullary Spinal Cord Arteriovenous Malformations (AVMs): A New Promising New Therapeutic Approach

A Population-Based Study of Brain Arteriovenous Malformation

Sensitivity of CT angiography, T2-weighted MRI, and magnetic resonance angiography in detecting cerebral arteriovenous malformations and associated aneurysms

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