Natural history and progression of primary chronic venous disorder

Davies, Alun H.; Lim, Chung Sim

doi:10.1016/j.jvs.2010.05.125

Cited by 3 publications

(6 citation statements)

References 42 publications

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“…The average baseline VCSS was 23.6 ±1.45. 21–26 The ulcers were present for an average of 18.8 7–29 months. Five patients were treated against type 2 diabetes mellitus, two patients suffered from coronary heart disease and five had hypertension.…”

Section: Methodsmentioning

confidence: 99%

“…Thereafter, povidone-iodine disinfection, lanolinzinc-oxide skin protectant treatment used in a 4-5 cm zone onto the intact skin edge, sterile gauze square to the wound bed and a high-compression elastic bandage from toes to above the knee joint was applied, in the order of listing. Patients were lying with the limb slightly raised in [15][16][17][18][19][20] degree position. In case of significant discharge, wound dressing was changed more than once a day.…”

Section: Perforator Ligature (Seps)mentioning

confidence: 99%

“…The average baseline VCSS was 23.6 AE 2.5. [19][20][21][22][23][24][25][26] Three patients had type 2 diabetes mellitus, three had coronary heart disease and six had treated hypertension. Five patients received anticoagulant treatment with acenocumarol, whereas three patients took salicylate on a regular basis.…”

Section: Patient Clinical Datamentioning

confidence: 99%

“…Despite correct treatment of lower extremity, ulcers can present a challenge and many of them will fail to heal without appropriate intervention(s). 18 Although the nature and the evolution of the CVI C5/6 are widely known, 19 it is far from being resolved. 20,21 In cases of refractory to conservative treatment, which are often neglected cases, specific surgical interventions play an inevitable role in the treatment of recalcitrant lower leg ulcers and dermatoliposclerosis and incompetent perforator veins (IPVs).…”

Section: Introductionmentioning

confidence: 99%

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The role of radical surgery in the management of CEAP C5/6 and lipodermatosclerosis

Mester

Laczik

2016

Phlebology

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Aim Analysis of the radical removing of the dermatosclerotic tissues and ulcer(s) with perforator veins dissection as well as local wound and standard compression treatment of CEAP C5/6 stage in a prospective comparative cohort study. Primary endpoint is to compare the results of the one-year follow-up regarding quality of life, vein clinical severity score, and ulcer healing process. Secondary endpoint is the precise presentation of the surgical technique. Tertiary endpoint is to demonstrate the photo-documented results of the postoperative wound treatment protocol. Method Clinical and statistical comparison of radical surgery versus solely wound care and compression in a cohort of 15 patients in each group (Groups 1, 2). In Group 1, radical removing of the dermatosclerotic pannicule and leg ulcer, perforator vein dissection, great saphenous vein, or small saphenous vein was performed. Quality of life , pain intensity, vein clinical severity score and patients' load capacity were compared. The tissue oxygen saturation changes were monitored via near infra-red spectroscopy. Results Both groups were statistically comparable. Wound healing in the operated group was 100% versus 60% in the second one, the difference was significant, p = 0.006. The quality of life: 45.33 versus 36.8, p < 0.001, intensity of leg restless and pain: 2.28 versus 5.3, p < 0.001, changes of vein clinical severity score: 5.27 versus 20.93, p < 0.001, changes of tO: 19.00 versus 6.07 in the upper third of the leg p < 0.001, proved significantly better in group 1 compared to 2. Load capacity was significantly better in group 1 than 2 at the end of the study. The average wound healing time was 113 days in group 1. Conclusion The radical surgery provides significantly better results, considering quality of life, vein clinical severity score, load capacity than the conservative treatment in this study.

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Section: Methodsmentioning

confidence: 99%

Section: Perforator Ligature (Seps)mentioning

confidence: 99%

Section: Patient Clinical Datamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The role of radical surgery in the management of CEAP C5/6 and lipodermatosclerosis

Mester

Laczik

2016

Phlebology

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“…Изучение структурной перестройки стенки большой подкожной вены (БПВ) на протяжении жизни человека при развитии хронических заболеваний вен является актуальной задачей флебологии [1][2][3][4]. Наряду с общей соединительнотканной пролиферацией, присутствующей при варикозной болезни, наступаю щие изменения в общей структуре венозной стенки касаются и гладкомышечных ее компонентов [5][6][7][8].…”

Section: Introductionunclassified

Morphological restructuring of smooth muscles elements of the wallgreat saphenous vein of a person on the lower leg during the development of varicose transformation

Sannikov

Shaydakov

2022

Ambulatornaya khirurgiya

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Introduction. Further study of the structural restructuring of the wall of the great saphenous vein throughout a person’s life with the development of chronic venous diseases is an urgent task of phlebology.The purpose of the study. Research of the morphological restructuring of smooth muscleselements of the human great saphenous vein wall on the calf in norm, ectasia and development of varicose transformation.Materials and methods. The study of morphological restructuring of the great saphenous vein wall on the calf was carried out in 3 comparison groups by light microscopy. In 1th group, the structure of the GSV wall was studied on autopsy material of people who died from various causes at the age of 5 to 80 years. In the 2nd and 3rd groups, fragments of GSV in the calf were taken by biopsy during the execution of the operations for varicose veins. All patients underwent ultrasound mapping before surgery to determine the presence and degree of ectasia, varicose transformation and retrograde blood flow. For histological analysis in the groups, 140 GSV fragments were removed in 1-group, 165 BPV fragments in 2-group, and 250 GSV fragments in 3-group.Results. The general morphological analysis of histological preparations made it possible to visually identify various variants of changes in smooth muscleselements inherent in the inner, middle and outer shells of the GSV wall. The selected variants of reconstruction of the smooth muscleselements were combined into 10 morphological types.Conclusion. Age-related morphological changes in the smooth muscleselements in the GSV wall on the calf, over the course of a person’s life, do not have the same character as changes occurring in its wall during the development of its ectasia and varicose transformation.

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