Natural healing-inspired collagen-targeting surgical protein glue for accelerated scarless skin regeneration

Jeon, Eun Young; Choi, Bong‐Hyuk; Jung, Dooyup; Hwang, Byeong Hee; Joon, Hyung

doi:10.1016/j.biomaterials.2017.04.041

Cited by 74 publications

(37 citation statements)

References 49 publications

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“…Autografted skin cells are also widely used for epidermal replacement (skin grafts or cell suspensions from another part of the patient's own body) and tissue engineering is used to reconstruct the dermis after deep injuries such as severe burns, to increase skin regeneration and reduce scarring 10 ; new biomimetics also help to inhibit scarring. 11 In contrast, it has proven difficult to achieve the dream of implanting human pancreatic islet cells to provide an intrinsic source of insulin to treat diabetes and other serious conditions. The clinical use of allogeneic human cells is associated with the usual major problems (limited availability of donor cells and immune rejection); there is intensive research in this area (reviewed in Aghazadeh and Nostro 12 ) and the use of human induced pluripotent stem cells (hiPSCs) to generate large numbers of autologous islet cells holds promise.…”

Section: Clinical Situationmentioning

confidence: 99%

“…Successful clinical transplantation of normal human cells (rather than organs) is classically demonstrated by bone‐marrow stem cell replacement (the allogenic donor cells need to be closely matched for histocompatibility). Autografted skin cells are also widely used for epidermal replacement (skin grafts or cell suspensions from another part of the patient's own body) and tissue engineering is used to reconstruct the dermis after deep injuries such as severe burns, to increase skin regeneration and reduce scarring; new biomimetics also help to inhibit scarring …”

Section: Introductionmentioning

confidence: 99%

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Obstacles and challenges for tissue engineering and regenerative medicine: Australian nuances

Grounds

2018

Clin Exp Pharma Physio

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The clinical need and historical approaches to tissue engineering as applied to regenerative medicine are introduced, along with comments on activities in this field around Australia, and then the huge advances for tissue culture studies are discussed (Part A). Combinations of human stem cells and new approaches for generating bioscaffolds present great opportunities for in vitro studies of basic biology and physiology, drug testing and high throughput screening for the pharmaceutical industry, and the advanced tissue engineering of organs and devices. The future here is bright. The major obstacles arise with in vivo application of these bioengineering advances using animal models and humans (Part B), and the complexity of living tissues and the challenges of increased scale required for clinical translation to the large human situation are first discussed. While clinical success seen with implantation of acellular bioscaffolds (with population by host cells) is likely to expand for human use, the major challenge relates to (generally) low survival in vivo of (donor or autologous) cells that are expanded and grown in tissue culture before implantation into the living body. Another major challenge is revascularisation of implanted tissues/organs at the human scale. The innovative approaches and rapid advances in tissue bioengineering hold great promise for overcoming these major obstacles and extending the clinical applications of these technologies.

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Section: Clinical Situationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Obstacles and challenges for tissue engineering and regenerative medicine: Australian nuances

Grounds

2018

Clin Exp Pharma Physio

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“…However, supply of autologous skin grafts is limited, especially for larger wound coverage such as with burns [1]. The field of tissue engineering has provided various biomaterial solutions to support wound healing [2][3][4][5][6][7]. Biomaterial approaches have included natural materials such as chitosan, collagen, degradable hydrogels, and protein glue [2][3][4]; and synthetic materials such as polymer nanofibers, bioactive glass, and electrospun fibers [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…The field of tissue engineering has provided various biomaterial solutions to support wound healing [2][3][4][5][6][7]. Biomaterial approaches have included natural materials such as chitosan, collagen, degradable hydrogels, and protein glue [2][3][4]; and synthetic materials such as polymer nanofibers, bioactive glass, and electrospun fibers [4][5][6][7]. Biomaterials have had success in supporting wound healing as scaffolding materials for endogenous fibroblasts and keratinocytes as they infiltrate the wound and repair the skin.…”

Section: Introductionmentioning

confidence: 99%

Mesenchymal Stem Cell Therapies for Skin Repair and Regeneration

2017

JDC

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In the clinic, partial to full-thickness skin defects are generally treated through debridement and patching with autologous skin grafts. Autologous skin grafts are in severely limited supply, especially for ill patients lacking healthy tissue to donate to themselves. Stem cells have come into interest as a novel, viable way to heal skin wounds. Mesenchymal stem cells (MSCs) are of particular interest due to its common mesoderm germ layer origins as skin tissue. Mesenchymal stem cells are primarily derived from bone marrow, adipose tissue and umbilical cord. Bone marrow MSCs have been widely applied to chronic wounds in non-diabetic and diabetic subjects with positive results for wound healing and closure. Adipose-derived stem cells (ASCs) are a more recent application to skin healing. It has been found that ASCs secrete growth factors positive for augmenting wound healing, such as TGF-β. ASCs are also a more attractive cell source for clinical use due their great abundance and ease of procurement from discarded tissues from cosmetic surgery procedures. Most recently, umbilical cord MSCs have been tested for its effects on wound healing, showing that the cells' paracrine effects can accelerate skin wound healing. Overall, mesenchymal stem cells show great promise to progress skin wound treatments, especially for chronic wounds. However, more clinical research is needed prior to patient application. Mesenchymal Stem Cell Therapies for Skin Repair and Regeneration 2/3Copyright: ©2017 Lam in group 1 and 76% of patients in group 2 did not need further wound care. In contrast, 80% of patients in the saline control group required surgical intervention. In a 16 month follow-up with group 2, the wound was completely healed with no signs of contracture.Chronic wounds are a notorious complication for diabetic patients. Bone marrow MSCs have been explored as a treatment option [15][16][17]. In one study, allogeneic MSCs were compared to the MSCs' acellular derivatives in a non-obese diabetic (NOD) mouse model [15]. The cells or acellular derivatives were intradermally injected around the wound site. Mice treated with the acellular derivative displayed significantly higher percentages of wound closure on days 4, 6, and 8 compared to wounds that received cells or control vehicles. Acellular products produced less pronounced inflammatory response, more granulation tissue, and a higher density of collagen fibers. This study suggests that growth factors present in bone marrow MSCs require time for cell release, whereas during the decellularization process these growth factors are released and readily available to stimulate the wound healing process. Adipose-derived MSCsWhile bone marrow MSCs can be difficult to obtain, adiposederived stem cells (ASCs) are much more abundant and are easily isolated from subcutaneous fat tissue and lipoaspirates. In addition, these adipose tissues are generally discarded from plastic surgery clinics, making excellent use of otherwise disposed tissue. ASCs have been widely explored for sk...

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“…Generally, the biosafety and new composite could be a great candidate for enhanced healing rate and high-quality and sufficient scar prevention. 43 Figure 6 shows the schematic representation of synthesis of this novel collagen. 43 Behind weak mechanical strength, low incorporation to native tissues and lack of antimicrobial properties hydrogels have been applied continually in tissue engineering.…”

mentioning

confidence: 99%

A review of using green chemistry methods for biomaterials in tissue engineering

Jahangirian¹,

Lemraski²,

Rafiee-Moghaddam³

et al. 2018

IJN

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Although environmentally safe, or green, technologies have revolutionized other fields (such as consumables, automobiles, etc.), its use in biomaterials is still at its infancy. However, in the few cases in which safe manufacturing technology and materials have been implemented to prevent postpollution and reduce the consumption of synthesized scaffold (such as bone, cartilage, blood cell, nerve, skin, and muscle) has had a significant impact on different applications of tissue engineering. In the present research, we report the use of biological materials as templates for preparing different kinds of tissues and the application of safe green methods in tissue engineering technology. These include green methods for bone and tissue engineering-based biomaterials, which have received the greatest amount of citations in recent years. Thoughts on what is needed for this field to grow are also critically included. In this paper, the impending applications of safe, ecofriendly materials and green methods in tissue engineering have been detailed.

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Natural healing-inspired collagen-targeting surgical protein glue for accelerated scarless skin regeneration

Cited by 74 publications

References 49 publications

Obstacles and challenges for tissue engineering and regenerative medicine: Australian nuances

Obstacles and challenges for tissue engineering and regenerative medicine: Australian nuances

Mesenchymal Stem Cell Therapies for Skin Repair and Regeneration

A review of using green chemistry methods for biomaterials in tissue engineering

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