Natural essential oils efficacious in internal organs fibrosis treatment: Mechanisms of action and application perspectives

Yu, Shuang; Long, Yu; Li, Dan; Ai, Shi; Deng, Jie; Ma, Yin; Wen, Jing; Li, Xiaoqiu; Zhang, Haoyang; Liu, Songyu; Wan, Jinyan; Li, Nan; Guo, Jiao

doi:10.1016/j.phrs.2022.106339

Cited by 10 publications

(5 citation statements)

References 120 publications

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“…In a study by Torres ( 28 ), it was not directly confirmed whether TQ led to the activation of the TGF-β pathway and subsequent downregulation of MUC4. TGF-β was, however, determined to be a key molecule for the formation of the extracellular matrix and for the classic antifibrotic effects of TQ ( 68 ). The activation of TGF-β by TQ to downregulate MUC4 is theoretically possible but needs further confirmation.…”

Section: Discussionmentioning

confidence: 99%

Advances in research on the relationship between thymoquinone and pancreatic cancer

Zhao

Liu

et al. 2023

Front. Oncol.

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Pancreatic cancer has one of the worst prognoses among the most common cancers in the world. Its characteristics include a high rate of metastasis and chemotherapeutic resistance, which present major challenges to the medical community. The potential anticancer effects of thymoquinone (TQ), which is the main bioactive compound of the black seeds of the Nigella sativa plant, have recently received widespread attention for their potential use in treating pancreatic cancer. TQ can inhibit cell proliferation, promote cancer cell apoptosis, inhibit cell invasion and metastasis, enhance chemotherapeutic sensitivity, inhibit angiogenesis, and exert anti-inflammatory effects. These anticancer effects predominantly involve the nuclear factor (NF)-κB, phosphoinositide 3 kinase (PI3K)/Akt, Notch, transforming growth factor (TGF)-β, c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAPK) signaling pathways as well as the regulation of the cell cycle, matrix metallopeptidase (MMP)-9 expression, and pyruvate kinase isozyme type M2 (PKM2) activity. TQ regulates the occurrence and development of pancreatic cancer at multiple levels and through multiple targets that communicate with each other. In this review, we summarize and discuss the analogs and carriers of TQ that have been developed in recent years. Given its multilevel anticancer effects, TQ may become a new therapeutic drug for treating pancreatic cancer in the future. This review presents a brief introduction to the research that has been conducted on TQ in relation to pancreatic cancer to provide a theoretical basis for future studies on the topic.

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Section: Discussionmentioning

confidence: 99%

Advances in research on the relationship between thymoquinone and pancreatic cancer

Zhao

Liu

et al. 2023

Front. Oncol.

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“…The mechanisms of the antibacterial action of EOs are thought to be increased cell permeability due to the hydrophobicity of EO [56,57] and their toxic effects on membrane structure and function [58]. It has also been previously observed that EOs exhibit higher activity against Gram-positive than Gram-negative bacteria, which is due to the presence of an outer membrane that restricts the diffusion of EO components [18].…”

Section: Antibacterial Properties Of Sceo and Soeomentioning

confidence: 99%

Salvia officinalis L. and Salvia sclarea Essential Oils: Chemical Composition, Biological Activities and Preservative Effects against Listeria monocytogenes Inoculated into Minced Beef Meat

Ben Akacha,

Ben Hsouna,

Generalić Mekinić

et al. 2023

Plants

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In this study, Salvia officinalis L. and Salvia sclarea essential oils (EOs) were investigated using gas chromatography-mass spectrometry (GC-MS) to describe their chemical composition. The obtained results show, for both EOs, a profile rich in terpene metabolites, with monoterpenes predominating sesquiterpenes but with significant qualitative and quantitative differences. The main compound found in the Salvia officinalis EO (SOEO) was camphor (19.0%), while in Salvia sclarea EO (SCEO), it was linalyl acetate (59.3%). Subsequently, the in vitro antimicrobial activity of the EOs against eight pathogenic strains was evaluated. The disc diffusion method showed a significant lysis zone against Gram-positive bacteria. The minimum inhibitory concentrations (MICs) ranged from 3.7 mg/mL to 11.2 mg/mL, indicating that each EO has specific antimicrobial activity. Both EOs also showed significant antiradical activity against DPPH radicals and total antioxidant activity. In addition, the preservative effect of SOEO (9.2%) and SCEO (9.2%), alone or in combination, was tested in ground beef, and the inhibitory effect against Listeria monocytogenes inoculated into the raw ground beef during cold storage was evaluated. Although the effect of each individual EO improved the biochemical, microbiological, and sensory parameters of the samples, their combination was more effective and showed complete inhibition of L. monocytogenes after 7 days of storage at 4 °C. The results show that both EOs could be used as safe and natural preservatives in various food and/or pharmaceutical products.

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“…The fact that essential oils and their components are quickly digested, do not build up in the body, and are quickly excreted after application to the skin strongly suggests that they can be used as effective antimicrobial agents [6]. The incorporation in carriers or scaffolds of such natural compounds derived from medicinal plants has gained a lot of interest and demand, especially in replacing antimicrobial drugs due to their minimal side effects and relative abundance [7,8].…”

Section: Introductionmentioning

confidence: 99%

Alginate-Based Hydrogels Enriched with Lavender Essential Oil: Evaluation of Physicochemical Properties, Antimicrobial Activity, and In Vivo Biocompatibility

Rusu,

Niță,

Roșca

et al. 2023

Pharmaceutics

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Owing to its antibacterial, anti-inflammatory, and antioxidant activities, in the last few years, lavender essential oil (LVO) has been used in medical applications as a promising approach for treating infected wounds. However, the practical applicability of LVO is limited by its high volatility and storage stability. This study aimed to develop a novel hybrid hydrogel by combining phytic acid (PA)-crosslinked sodium alginate (SA) and poly(itaconic anhydride-co-3,9-divinyl-2,4,8,10-tetraoxaspiro[5.5] undecane (PITAU) and evaluate its potential effectiveness as an antibacterial wound dressing after incorporating LVO. The influence of the mass ratio between SA and PITAU on the properties and stability of hydrogels was investigated. After LVO loading, the effect of oil addition to hydrogels on their functional properties and associated structural changes was studied. FTIR analysis revealed that hydrogen bonding is the primary interaction mechanism between components in the hybrid hydrogels. The morphology was analyzed using SEM, evidencing a porosity dependent on the ratio between SA and PITAU, while LVO droplets were well dispersed in the polymer blend. The release of LVO from the hydrogels was determined using UV-VIS spectroscopy, indicating a sustained release over time, independent of the LVO concentration. In addition, the hybrid hydrogels were tested for their antioxidant properties and antimicrobial activity against Gram-positive and Gram-negative bacteria. Very good antimicrobial activity was obtained in the case of sample SA_PITAU3+LVO10% against S. aureus and C. albicans. Moreover, in vivo tests showed an increased antioxidant effect of the SA_PITAU3+LVO10% hydrogel compared to the oil-free scaffold that may aid in accelerating the healing process of wounds.

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Natural essential oils efficacious in internal organs fibrosis treatment: Mechanisms of action and application perspectives

Cited by 10 publications

References 120 publications

Advances in research on the relationship between thymoquinone and pancreatic cancer

Advances in research on the relationship between thymoquinone and pancreatic cancer

Salvia officinalis L. and Salvia sclarea Essential Oils: Chemical Composition, Biological Activities and Preservative Effects against Listeria monocytogenes Inoculated into Minced Beef Meat

Alginate-Based Hydrogels Enriched with Lavender Essential Oil: Evaluation of Physicochemical Properties, Antimicrobial Activity, and In Vivo Biocompatibility

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