Natural drug physcion encapsulated zeolitic imidazolate framework, and their application as antimicrobial agent

Soomro, Najaf Ali; Wu, Qiao; Amur, Safdar Ali; Liang, Hao; Rаhmаn, Аziz Ur; Yuan, Qeping; Wei, Yun

doi:10.1016/j.colsurfb.2019.110364

Cited by 63 publications

(25 citation statements)

References 17 publications

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“…The PXRD pattern of pure PTN (Figure 5A) displayed well-resolved characteristic diffraction peaks at different 2θ, revealing its crystalline character. The position of peaks corresponds to what has previously been described in the literature [43]. In the case of HP-β-CD (Figure 5B), a diffuse pattern without any sharp peaks was obtained, indicating its amorphous nature.…”

Section: Powder X-ray Diffraction (Pxrd)supporting

confidence: 85%

Parietin Cyclodextrin-Inclusion Complex as an Effective Formulation for Bacterial Photoinactivation

et al. 2022

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Multidrug resistance in pathogenic bacteria has become a significant public health concern. As an alternative therapeutic option, antimicrobial photodynamic therapy (aPDT) can successfully eradicate antibiotic-resistant bacteria with a lower probability of developing resistance or systemic toxicity commonly associated with the standard antibiotic treatment. Parietin (PTN), also termed physcion, a natural anthraquinone, is a promising photosensitizer somewhat underrepresented in aPDT because of its poor water solubility and potential to aggregate in the biological environment. This study investigated whether the complexation of PTN with (2-hydroxypropyl)-β-cyclodextrin (HP-β-CD) could increase its solubility, enhance its photophysical properties, and improve its phototoxicity against bacteria. At first, the solubilization behavior and complexation constant of the PTN/HP-β-CD inclusion complexes were evaluated by the phase solubility method. Then, the formation and physicochemical properties of PTN/HP-β-CD complexes were analyzed and confirmed in various ways. At the same time, the photodynamic activity was assessed by the uric acid method. The blue light-mediated photodegradation of PTN in its free and complexed forms were compared. Complexation of PTN increased the aqueous solubility 28-fold and the photostability compared to free PTN. PTN/HP-β-CD complexes reduce the bacterial viability of Staphylococcus saprophyticus and Escherichia coli by > 4.8 log and > 1.0 log after irradiation, respectively. Overall, the low solubility, aggregation potential, and photoinstability of PTN were overcome by its complexation in HP-β-CD, potentially opening up new opportunities for treating infections caused by multidrug-resistant bacteria.

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Section: Powder X-ray Diffraction (Pxrd)supporting

confidence: 85%

Parietin Cyclodextrin-Inclusion Complex as an Effective Formulation for Bacterial Photoinactivation

et al. 2022

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“…30,[36][37][38] To the best of our knowledge, the correlation between the decomposition of ZIF8 in acid-base environments and changes in ZIF8-modied materials has not been analyzed in detail. 39,40 In this study, we synthesized ZIF8-derived nanostructures incorporated with doxorubicin (Dox), an anticancer drug, via the external coating of the polyacrylic acid (PAA) layer. The localization and association of Dox in ZIF8 and its interaction with PAA were investigated by C 13 nuclear magnetic resonance (NMR) and Fourier transform infrared (FTIR) spectroscopy.…”

Section: Introductionmentioning

confidence: 99%

“…30,36–38 To the best of our knowledge, the correlation between the decomposition of ZIF8 in acid–base environments and changes in ZIF8-modified materials has not been analyzed in detail. 39,40 …”

Section: Introductionmentioning

confidence: 99%

pH-triggered degradation and release of doxorubicin from zeolitic imidazolate framework-8 (ZIF8) decorated with polyacrylic acid

Tran

Lee

2021

RSC Adv.

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“…Previously, emodin, physcion, and chrysophanol have shown antibacterial potential against a wide spectrum of bacterial species. However, their exact mode of action is still elusive [21][22][23][24]. Anthrarufin showed moderate activity against Gyr-B, but its activity against Ddl-B was comparable to the reference inhibitor D-cycloserine.…”

Section: In Vitro Validationmentioning

confidence: 99%

In Silico-Based Discovery of Natural Anthraquinones with Potential against Multidrug-Resistant E. coli

et al. 2022

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E. coli is a Gram-negative bacterium that causes different human infections. Additionally, it resists common antibiotics due to its outer protective membrane. Natural products have been proven to be efficient antibiotics. However, plant natural products are far less explored in this regard. Accordingly, over 16,000 structures covering almost all African medicinal plants in AfroDb in a structural-based virtual screening were used to find efficient anti-E. coli candidates. These drug-like structures were docked into the active sites of two important molecular targets (i.e., E. coli’s Ddl-B and Gyr-B). The top-scoring hits (i.e., got docking scores < −10 kcal/mol) produced in the initial virtual screening (0.15% of the database structures for Ddl-B and 0.17% of the database structures for Gyr-B in the database) were further refined using molecular dynamic simulation-based binding free energy (ΔG) calculation. Anthraquinones were found to prevail among the retrieved hits. Accordingly, readily available anthraquinone derivatives (10 hits) were selected, prepared, and tested in vitro against Ddl-B, Gyr-B, multidrug-resistant (MDR) E. coli, MRSA, and VRSA. A number of the tested derivatives demonstrated strong micromolar enzyme inhibition and antibacterial activity against E. coli, MRSA, and VRSA, with MIC values ranging from 2 to 64 µg/mL. Moreover, both E. coli’s Ddl-B and Gyr-B were inhibited by emodin and chrysophanol with IC50 values comparable to the reference inhibitors (IC50 = 216 ± 5.6, 236 ± 8.9 and 0.81 ± 0.3, 1.5 ± 0.5 µM for Ddl-B and Gyr-B, respectively). All of the active antibacterial anthraquinone hits showed low to moderate cellular cytotoxicity (CC50 > 50 µM) against human normal fibroblasts (WI-38). Furthermore, molecular dynamic simulation (MDS) experiments were carried out to reveal the binding modes of these inhibitors inside the active site of each enzyme. The findings presented in this study are regarded as a significant step toward developing novel antibacterial agents against MDR strains.

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Natural drug physcion encapsulated zeolitic imidazolate framework, and their application as antimicrobial agent

Cited by 63 publications

References 17 publications

Parietin Cyclodextrin-Inclusion Complex as an Effective Formulation for Bacterial Photoinactivation

Parietin Cyclodextrin-Inclusion Complex as an Effective Formulation for Bacterial Photoinactivation

pH-triggered degradation and release of doxorubicin from zeolitic imidazolate framework-8 (ZIF8) decorated with polyacrylic acid

In Silico-Based Discovery of Natural Anthraquinones with Potential against Multidrug-Resistant E. coli

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