Natural deep eutectic solvents-mediated extractions: The way forward for sustainable analytical developments

Fernández, María de los Ángeles; Boiteux, Joana Jaqueline; Espino, Magdalena; Gomez, Federico José Vicente; Silva, María Fernanda

doi:10.1016/j.aca.2018.07.059

Cited by 213 publications

(92 citation statements)

References 57 publications

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“…Under optimal conditions (temperature and stirring time), an eutectic mixture with a melting point lower than that of the compounds that make up the mixture is formed [23]. Otherwise, if the eutectic mixture consists of metabolites naturally present in all types of cells and organisms, these newly formed systems are called "Natural Deep Eutectic Solvents" (NADESs) [24]. DESs have already shown applications in various fields, including organic synthesis [25], preparation of inorganic materials [26], and biochemistry [27].…”

Section: Introductionmentioning

confidence: 99%

Choline Chloride Based Natural Deep Eutectic Solvents as Extraction Media for Extracting Phenolic Compounds from Chokeberry (Aronia melanocarpa)

et al. 2020

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For the isolation of selected phenolic compounds from dried chokeberries, natural deep eutectic solvents (NADESs) were investigated as a green alternative to conventionally used extraction solvents. Four types of NADESs were synthesised, with choline chloride as the hydrogen bond acceptor in combination with different hydrogen bond donors (sugars, organic acid and urea). Ultrasound-assisted extraction was used to improve the extractability of the phenolic compounds and the results were compared to those obtained with 80% methanol as the extraction media. The highest values of total phenols and total flavonoids were found in the extract obtained with choline chloride–fructose NADES (36.15 ± 3.39 mg gallic acid g−1 dry weight (DW) and 4.71 ± 0.33 mg rutin g−1 DW, respectively). The extraction recoveries for the individual phenolic compounds depended strongly on the phenolic compound’s structure, with relative mean values between 70% and 97%.

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Section: Introductionmentioning

confidence: 99%

Choline Chloride Based Natural Deep Eutectic Solvents as Extraction Media for Extracting Phenolic Compounds from Chokeberry (Aronia melanocarpa)

et al. 2020

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“…Deep eutectic solvents (DES), some also referred to as low-transition temperature mixtures (LTTMs), are designer liquids composed usually of a constituent serving as a hydrogen bond donor (HBD) and another one serving as a hydrogen bond acceptor (HBA). These neoteric materials have an assortment of peculiar properties, such as low or no volatility and flammability, absence of toxicity, tunability, stability, low cost, recyclability and biodegradability, that make them ideal for the development of green extraction methodologies [13]. Indeed, over the last 3 years, a number of studies demonstrated the efficacy of DES as solvents for task-specific extractions, offering new potential pathways in polyphenol extraction [14].…”

Section: Introductionmentioning

confidence: 99%

Polyphenol Extraction from Humulus lupulus (Hop) Using a Neoteric Glycerol/L-Alanine Deep Eutectic Solvent: Optimisation, Kinetics and the Effect of Ultrasound-Assisted Pretreatment

et al. 2019

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The investigation presented herein had as its scope the development of an integrated process for the efficient extraction of polyphenols from hop. For this purpose, a novel, natural deep eutectic solvent (DES) was synthesised, composed of glycerol and L-alanine, and the process was optimised by deploying a response surface methodology based on a Box-Behnken design. The variables considered were the DES/water proportion, the liquid-to-solid ratio and the stirring speed. Under the optimised conditions, the yield in total polyphenols achieved was 118.97 ± 8.27 mg gallic acid equivalents per g of dry mass. Ultrasonication, incorporated into the process as a pretreatment step, was shown to significantly change the kinetic pattern of polyphenol extraction and contributed to attaining higher yields only at 80 • C, whereas at lower temperatures a supressing effect was observed. Furthermore, increasing temperature was negatively correlated with the second-order extraction rates, evidencing a slow-down of the extraction rate at elevated temperatures.

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“…These compounds show high diversity, are biodegradable and present very low toxicology, making them also attractive for pharmaceutical purposes. In the last few years, the applicability of (NA)DES has been demonstrated for organic extractions [22,23], for electrochemical purposes [24] and in catalytic procedures [25,26] Regarding this last application, DESs have been employed as solvents, cosolvents, additives or supports to anchor catalysts and/or solvents in a catalytic process.…”

Section: Introductionmentioning

confidence: 99%

Positive Impact of Natural Deep Eutectic Solvents on the Biocatalytic Performance of 5-Hydroxymethyl-Furfural Oxidase

2020

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Deep eutectic solvents (DESs) have been applied as cosolvents in various biocatalytic processes during recent years. However, their use in combination with redox enzymes has been limited. In this study, we have explored the beneficial effects of several DES as cosolvents on the performance of 5-hydroxymethylfurfural oxidase (HMFO), a valuable oxidative enzyme for the preparation of furan-2,5-dicarboxylic acid (FDCA), and other compounds, such as carbonyl compounds and carboxylic acids. The use of natural DESs, based on glucose and fructose, was found to have a positive effect. Higher conversions are obtained for the synthesis of several oxidized compounds, including FDCA. Depending on the type of DES, the stability of HMFO could be significantly improved. As the use of DES increases the solubility of many substrates while they only mildly affect dioxygen solubility, this study demonstrates that biocatalysis based on HMFO and other redox biocatalysts can benefit from a carefully selected DES.

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Natural deep eutectic solvents-mediated extractions: The way forward for sustainable analytical developments

Cited by 213 publications

References 57 publications

Choline Chloride Based Natural Deep Eutectic Solvents as Extraction Media for Extracting Phenolic Compounds from Chokeberry (Aronia melanocarpa)

Choline Chloride Based Natural Deep Eutectic Solvents as Extraction Media for Extracting Phenolic Compounds from Chokeberry (Aronia melanocarpa)

Polyphenol Extraction from Humulus lupulus (Hop) Using a Neoteric Glycerol/L-Alanine Deep Eutectic Solvent: Optimisation, Kinetics and the Effect of Ultrasound-Assisted Pretreatment

Positive Impact of Natural Deep Eutectic Solvents on the Biocatalytic Performance of 5-Hydroxymethyl-Furfural Oxidase

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