Natural cycle IVF reduces the risk of low birthweight infants compared with conventional stimulated IVF

Abstract

The study was supported by the following grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD K12HD047018 (W.M.), NICHD K12HD001271 (L.A.K.). The authors have no competing interests.

Clinical and neonatal outcomes of intrauterine insemination with frozen donor sperm

“…Therefore, those in the AID group were more likely to use a natural cycle than those in the AIH group. Cycles with ovarian stimulation have been associated with a higher risk of LBW in infants than natural cycles (Kalra et al 2011;Mak et al 2016). There were 12 infants with LBW from ovarian stimulation cycles in the AIH group, while only 1 infant with LBW from natural cycle was born in the AID group.…”

The greater incidence of small‐for‐gestational‐age newborns after gonadotropin‐stimulated in vitro fertilization with a supraphysiological estradiol level on ovulation trigger day

“…For children conceived by NC‐IVF, the incidence of SGA was analyzed only once, by Mak et al . They compared 190 singletons after NC‐IVF with 174 after c‐IVF.…”

“…A recent systematic review found a significantly higher risk of low birthweight (LBW) after c‐IVF (risk ratio 1.95; 95% confidence interval [CI] 1.03‐3.67) compared with modified IVF/NC‐IVF therapy . Studies included in the review focused on birthweight as the main outcome and defined LBW as <2500 g, without taking into consideration exact gestational age . Using birthweight percentiles adjusts for gestational age and sex of the neonate.…”

“…9 Studies included in the review focused on birthweight as the main outcome and defined LBW as <2500 g, without taking into consideration exact gestational age. 6,10,11 Using birthweight percentiles adjusts for gestational age and sex of the neonate.…”

What Kind of Policies for Fertility Treatment would Improve Affordability and Outcomes for Individuals and the Public?

“…In particular, fertility treatments that seek to balance optimal or physiologic reproductive function, surgically and/or medically, may result in lower incidence of multiple gestation and low birthweight. [18][19][20] Healthier birth outcomes for subfertile couples in the United States are not going to be achieved by simply expanding affordability and utilization of IVF. If the public has an interest in more equitable coverage for fertility treatment, it also has an interest in maximizing the public health outcomes related to fertility treatment.…”