Clinical and neonatal outcomes of intrauterine insemination with frozen donor sperm

Chen, Linjun; Zhu, Li; Cai, Chenggang; Yan, Guijun; Sun, Haixiang

doi:10.1080/19396368.2018.1453563

Cited by 9 publications

(17 citation statements)

References 52 publications

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“…Based the data of the Society of Assisted Reproductive Technology Clinic Outcome Reporting System, a 42 g increase in birthweight was reported in sperm donation offspring comparing with that in partner sperm offspring [22]. Similarly, Chen et al reported an increase in birthweight in children born after frozen donor sperm intrauterine insemination comparing with those after paternal sperm intrauterine insemination [23]. The heterogeneous results may warrant further investigation on unmeasured or unknown factors that may affect the birthweight in cooperated with sperm cryopreservation.…”

Section: Discussionmentioning

confidence: 99%

The effect of epididymal sperm cryopreservation on neonatal birthweight following PESA-ICSI

Cai

Liu

Chen

et al. 2021

Arch Gynecol Obstet

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Purpose: To compare the neonatal birthweight of singletons derived from ICSI cycles with fresh or frozenthawed epididymal sperm in patients with obstructive azoospermia Methods: A total of 436 singletons derived from ICSI cycles with fresh (n=220) or frozen-thawed (n=216) epididymal sperm in obstructive azoospermia evaluated from 2012 to 2018 in the retrospective study. Multivariate generalized linear model was used to analyze the association between epididymal sperm cryopreservation and neonatal birthweight.Result(s): The crude birthweight and z-score in neonates derived from frozen-thawed epididymal sperm were signi cantly lower than those from fresh epididymal sperm (3186.57g vs 3303.61g and -0.18 vs 0.08, respectively), with a mean difference of 117.04 (95%CI: 32.36 to 201.72) g and 0.25 (95%CI: 0.06 to 0.45). Adjusted for confounders including parental age and BMI, maternal ovarian reserve, paternal FSH and T levels, peak E2 during OPU cycles, frozen-thawed embryo transfer, embryo development stage, gestational age, maternal parity and child gender, the multivariate model suggested that singletons conceived from ICSI with fresh epididymal sperm was on average 91.21 g heavier than those conceived from ICSI with frozen-thawed epdidiymal sperm (95%CI:12.72 to 166.7, P=0.016). Conclusion(s): Cryopreservation of epididymal sperm may negatively affect birthweight

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Section: Discussionmentioning

confidence: 99%

The effect of epididymal sperm cryopreservation on neonatal birthweight following PESA-ICSI

Cai

Liu

Chen

et al. 2021

Arch Gynecol Obstet

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“…Compared to other assisted reproductive technologies, AIH costs less, does less harm to patients, and is relatively easy to use -these characteristics make it a more readily accepted treatment option for infertile couples. 12,13 However, the clinical pregnancy rate of AIH is only about 8-22 %, which is a major challenge for patients and medical workers. 12,14 Hence, improving the clinical pregnancy rate of AIH is a hot research topic in the field of infertility.…”

Section: Discussionmentioning

confidence: 99%

“…AIH is a suitable infertility treatment for men with mild oligospermia, retrograde ejaculation, hypospadias, sexual dysfunction, and anti‐sperm antibody in semen, as well as for women with cervical deformity, abnormal cervical mucus, endometriosis, unexplained infertility, and so on. Compared to other assisted reproductive technologies, AIH costs less, does less harm to patients, and is relatively easy to use – these characteristics make it a more readily accepted treatment option for infertile couples 12,13 . However, the clinical pregnancy rate of AIH is only about 8–22 %, which is a major challenge for patients and medical workers 12,14 .…”

Section: Discussionmentioning

confidence: 99%

Associations between vaginal flora, MIP‐1α, IL‐17A, and clinical pregnancy rate in AIH

Yang

Gao

Wang

et al. 2022

American J Rep Immunol

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Problem To investigate how asymptomatic bacterial imbalance affects the clinical pregnancy rate after artificial insemination with the husband's semen (AIH). Methods This study included married heterosexual couples who underwent AIH. According to the follow‐up results, participants were divided into the pregnancy and non‐pregnancy groups. Based on the first 10 pair participants in each group with vaginal flora bacterial 16S rRNA sequencing results, six semen samples received bacterial‐sperm mixed test. Moreover, 34 cytokines were detected in the peripheral blood sera of the first three pairs by high‐throughput Luminex, which were verified in vaginal secretions, cervical mucus, and blood sera from the first 200 pairs by ELISA. Results The results of the 16S sequencing of vaginal secretions showed that compared with the pregnant group, the non‐pregnant group had a significantly increased bacterial species diversity, which was mainly manifested by a decrease in Lactobacillus crispatus and an increase in Prevotella bivia. When Prevotella bivia or Lactobacillus crispatus were mixed with sperms, the sperm motility was decreased (p < .05). The vaginal posterior fornix secretions, cervical mucus, and peripheral blood sera of the non‐pregnant group showed decreased levels of MIP‐1α and increased levels of IL‐17A (p < .05). Conclusion The imbalance of vaginal flora leading to the increase of Prevotella bivia and the decrease of Lactobacillus crispatus may cause an imbalance of immune regulation. Low expression of MIP‐1α and high expression of IL‐17A were associated with reduced clinical pregnancy rate in AIH.

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“…It can be observed that neck translucency thickness (NT) as well as the blood flow rate through the venous line (DV-PI) were statistically significantly higher in fetuses burdened with a heart defect in comparison to fetuses in which no such defects were determined when fertilization occurred as a result of sexual intercourse in the group of women in which no assisted reproduction techniques were used (11 of 1298 cases) as well as in the group of women after pharmacologically induced ovulation (3 of 137 cases). However, the obtained results did not indicate that any fetus which developed as a result of intracytoplasmic injection was fraught with a congenital heart defect; therefore, the likely cause of a heart defect not being identified amongst these fetuses may result from the fact that the sperm used for fertilization is selected before it is introduced to the egg [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Risk Assessment of the Increased Occurrence of Congenital Cardiac and Non-Cardiac Defects in Fetuses with a Normal Karyotype after Assisted Fertilization in Comparison to Natural Fertilization Based on Ultrasound Diagnostics

Serafin¹,

Grabarek²,

Boroń³

et al. 2021

JCM

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The goal of the study was to assess changes in parameters based on ultrasound examinations—these were Crown Rump Length (CRL), Nuchal Translucency (NT), Fetal Heart Rate (FHR), and Pulsatility Index for Ductus Venosus (DV-PI)—in the first trimester of pregnancy in women in which there was a natural initiation of the pregnancy due to spontaneous ovulation, women in which the pregnancy was initiated as a result of stimulated ovulation, as well as in the group in which pregnancy was achieved through the use of In-Vitro Fertilization (IVF)-assisted reproduction. A total of 1581 women became pregnant without the use of assisted reproduction methods. Out of 283 pregnancies, in 178 patients, induced ovulation was utilized. Next, 137 women had sexual intercourse and became pregnant; 41 of them became pregnant through Intrauterine Insemination (IUI) as a result of Artificial Insemination by Husband (AIH), and 13 became pregnant after Artificial Insemination by Donor (AID). The third group consisted of 105 women subjected to Controlled Ovarian Hyperstimulation (COH). In this group of pregnant women, 53 pregnancies were resultant of Intracytoplasmic Sperm Injection (ICSI), and 52 pregnancies were the result of Intracytoplasmic Morphologically selected Sperm Injection (IMSI). The obtained results did not indicate that the chosen method of fertilization or the chosen ovulation method had a statistically significant effect on the development risk of congenital heart or non-heart defects in the fetus.

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Clinical and neonatal outcomes of intrauterine insemination with frozen donor sperm

Abstract: AID: artificial insemination by a donor; AIH: artificial insemination by the husband; ART: assisted reproduction technology; FET: frozen embryo transfer; IVF: in vitro fertilization; ICSI: intracytoplasmic sperm injection; IUI: intrauterine insemination; LBW: low birth weight.

Cited by 9 publications

References 52 publications

The effect of epididymal sperm cryopreservation on neonatal birthweight following PESA-ICSI

The effect of epididymal sperm cryopreservation on neonatal birthweight following PESA-ICSI

Associations between vaginal flora, MIP‐1α, IL‐17A, and clinical pregnancy rate in AIH

Risk Assessment of the Increased Occurrence of Congenital Cardiac and Non-Cardiac Defects in Fetuses with a Normal Karyotype after Assisted Fertilization in Comparison to Natural Fertilization Based on Ultrasound Diagnostics

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